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Department of Medicine

Department of Medicine

 Division of Renal-Electrolyte

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photo Mohammad Al-bataineh, DVM, MS, PhD

Post-doctoral Associate, University of Pittsburgh, 2012

Post-doctoral Scholar, University of Pittsburgh, 2016

Instructor in Medicine, 2017

Email: mma57@pitt.edu

Phone: 412-648-9081

Contact
Office: 3550 Terrace Street
931 Scaife Hall
Pittsburgh, PA 15261
 
Phone: 412-648-9081
Fax:
E-mail: mma57@pitt.edu
Education and Training
Education
Doctor of Veterinary Medicine, Jordan University of Science and Technology, 2000
M.S., Physiology & Pharmacology, Jordan University of Science and Technology, 2002
Ph.D., Clinical Pharmacology, Kansas State University, 2010
Research Interest
Dr. Al-bataineh is a DVM-PhD scientist, who studies epithelial transport physiology and kidney pathophysiology. His research studies the mechanism of metabolic regulation of cellular, organ and body homeostasis through cell surface expression of epithelial membrane transporters. Presently, Dr. Al-bataineh is interested in understanding the acute and chronic effects of the cell surface sensor Mucin 1, (human MUC1, mouse Muc1) during metabolic stress conditions, such as ischemia-reperfusion injury (IRI) and acid-base disorders. In his training and research projects, Dr. Al-bataineh has employed both animal and cell culture model systems and developed expertise in renal physiology, and kidney histology, microscopy, and pathophysiology. He has spearheaded several significant research projects resulting in publications in high-impact journals such as Nature Chemical Biology, Journal of Proteome Research, and American Journal of Physiology. Dr. Al-bataineh has been PI on two NIH grants (NRSA, and K01), and one pharmaceutical fellowship award (SANOFI). He has received several awards from national societies, including the Epithelial Transport Group of the American Physiological Society (APS), and the Steve Hebert Award Session of the Experimental Biology (EB). Beyond his research success (including 15 papers to date and others in preparation), Dr. Al-bataineh has been fortunate to obtain a wide-range of teaching experiences. He has had the opportunity to teach a variety of courses (with Labs) including Human Physiology, Animal Physiology, and Pharmacology. Moreover, he has supervised many students and provides them with an appropriate feedback after evaluating their progress. Dr. Al-bataineh also serves as a reviewer in Frontiers in Physiology Journal.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Al-Bataineh MM, Sutton TA, Hughey RP. Novel roles for mucin 1 in the kidney. Current Opinion in Nephrology and Hypertension. 2017; 26(5): SEP 2017: 384–391.
Al-Bataineh, MM, Kinlough, CL, Poland, PA, Pastor-Soler, NM, Sutton, TA, Mang, HE, Bastacky, SI, Gendler, SJ, Madsen, CS, Singh, S, Monga, SP, Hughey, RP. Muc1 enhances the beta-catenin protective pathway during ischemia-reperfusion injury. American journal of physiology. Renal physiology. 2016.
Al-Bataineh MM, Li H, Ohmi K, Gong F, Marciszyn AL, Naveed S, Zhu X, Neumann D, Wu Q, Cheng L, Fenton RA, Pastor-Soler NM, Hallows KR. Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells. American journal of physiology. Renal physiology. 2016; Nov 1; 311(5): F890–F900.
Al-Bataineh, MM, Gong, F, Marciszyn, A, Myerburg, MM, Pastor-Soler, NM. Regulation of Proximal Tubule Vacuolar H+-ATPase by PKA and AMP-Activated Protein Kinase. American journal of physiology. Renal physiology. 2014; 306(9): F981-995.
Al-Bataineh, MM, Alzamora, R, Ohmi, K, Ho, PY, Marciszyn, A, Gong, F, Li, H, Hallows, KR, Pastor-Soler, NM. Aurora Kinase A Activates the Vacuolar H+-ATPase (V-ATPase) in Kidney Carcinoma Cells. American journal of physiology. Renal physiology. 2016.
Roy, A & Al-bataineh, MM, Pastor-Soler, NM. Collecting Duct Intercalated Cell Function and Regulation. Clinical journal of the American Society of Nephrology. 2015; 10(2): 305-324.
Gidon, A, Al-Bataineh, MM, Jean-Alphonse, FG, Stevenson, HP, Watanabe, T, Louet, C, Khatri, A, Calero, G, Pastor-Sole, NM, Gardella, TJ, Vilardaga, JP. Endosomal G protein-coupled receptor signaling turned off by negative feedback actions of PKA and v-ATPase. Nature chemical biology. 2014; 10(9): 707-709.
Alzamora, R, Al-Bataineh, MM, Liu, W, Gong, F, Li, H, Thali, RF, Joho-Auchli, Y, Brunisholz, RA, Satlin, LM, Neumann, D, Hallows, KR, Pastor-Soler, NM. AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. American journal of physiology. Renal physiology. 2013; 305(7): F943-956.
Pastor-Soler, NM, Sutton, TA, Mang, HE, Kinlough, CL, Gendler, SJ, Madsen, CS, Bastacky, SI, Ho, J, Al-Bataineh, MM, Hallows, KR, Singh, S, Monga, SP, Al-BKobayashi, H, Haase, VH, Hughey, RP. Muc1 is Protective in a Mouse Model of Kidney Ischemia-Reperfusion Injury. American journal of physiology. Renal physiology. 2015; 308(12): F1452-1462.
Rondanino, C, Poland, PA, Kinlough, CL, Li, H, Rbaibi, Y, Myerburg, MM, Al-bataineh, MM, Kashlan, OB, Pastor-Soler, NM, Hallows, KR, Weisz, OA, Apodaca, G, Hughey, RP. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. American journal of physiology. Renal physiology. 2011; 301(3): F622-633.
Sponsored Research/Activities
Title: Role of Muc1 in the B-Catenin Response to Acute Kidney Injury
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: K01 DK109038
Start Year: 2016
End Year: 2021
Title: Aquaporin-2 (AQP-2) Regulation by AMP-activated Kinase (AMPK) in the Kidney Collecting Duct
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: F32 DK097889
Start Year: 2013
End Year: 2016