Department of Medicine
Faculty Profiles by Division

Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine

Faculty Profiles
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photo Joseph M. Pilewski, MD

Pulmonary, Allergy and Critical Care Medicine

Associate Chief, Division of Pulmonary, Allergy & Critical Care Medicine

Professor of Medicine and Pediatrics

Email: pilewskijm@upmc.edu

Phone: 412-647-8477
Contact
Office: UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-647-8477
Fax: 412-692-2260
E-mail: pilewskijm@upmc.edu
Administrative Assistant:
M. Sharon Droppa
Email: droppam2@upmc.edu
Phone: 412-647-8477
Fax: 412-692-2260
Education and Training
Education
BA, Philosophy, College of the Holy Cross, 1983
MD, University of Rochester, 1987
Training
Medical Internship, Hospital of the University of Pennsylvania, 1988
Medical Residency, Hospital of the University of Pennsylvania, 1990
Pulmonary & Critical Care Fellowship, Hospital of the University of Pennsylvania, 1991
Research Fellowship, University of Pennsylvania - Pulmonary Division, 1994
Research Interest
Dr. Pilewski’s research interests mirror his clinical interest and expertise. He directs a research program in epithelial cell biology focused on ion transport and mucin structure and function in normal and Cystic Fibrosis airways, and leads translational research projects focused on development of new therapies for CF and other diseases of mucus obstruction, and identification of biomarkers of disease activity. He is a co-investigator on NIH and CF Foundation sponsored center grants focused on CF, and a co-investigator in the Cystic Fibrosis Foundation Therapeutics Development Network.
Clinical Interest
Dr. Pilewski has a longstanding interest in Cystic Fibrosis and other diseases causing bronchiectasis and bronchiolitis. He is Co-director of the Adult Cystic Fibrosis program at the Antonio J and Janet Palumbo CF Center at Children’s Hospital of Pittsburgh of UPMC, and the University of Pittsburgh Medical Center. Dr. Pilewski’s other focus is lung transplantation, with special interest in patients with suppurative lung diseases like CF. He has been Medical Director of the Lung Transplant Program at the University of Pittsburgh Medical Center since 2004.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Locke, LW, Myerburg, MM, Weiner, DJ, Markovetz, MR, Parker, RS, Muthukrishnan, A, Weber, L, Czachowski, MR, Lacy, RT, Pilewski, JM, Corcoran, TE. Pseudomonas infection and mucociliary and absorptive clearance in the cystic fibrosis lung. Eur Respir J. 2016; May;47(5): 1392-401.
Morrell, MR, Pilewski, JM. Lung Transplantation for Cystic Fibrosis. Clin Chest Med. 2016; Mar;37(1): 127-38.
Crespo, MM, Bermudez, CA, Dew, MA, Johnson, BA, George, MP, Bhama, J, Morrell, M, D'Cunha, J, Shigemura, N, Richards, TJ, Pilewski, JM. Lung Transplantation in Patients with Scleroderma Compared with Pulmonary Fibrosis: Short and Long-term Outcomes in a Single Institution. Ann Am Thorac Soc. 2015; Dec 15.
Heidrich, E, Carattino, MD, Hughey, RP, Pilewski, JM, Kleyman, TR, Myerburg, MM. Intracellular Na+ regulates epithelial Na+ channel maturation. J Biol Chem. 2015; May 1;290(18): 11569-77.
Taylor-Cousar, J, Niknian, M, Gilmartin, G, Pilewski, JM, for the VX11-770-901 investigators. Effect of ivacaftor in patients with advanced cystic fibrosis and a G551D-CFTR mutation: Safety and efficacy in an expanded access program in the United States. J Cyst Fibros. 2015; Feb 11: S1569-1993.
Bermudez, CA, Shiose, A, Esper, SA, Shigemura, N, D'Cunha, J, Bhama, JK, Richards, TJ, Arlia, P, Crespo, MM, Pilewski, JM. Outcomes of intraoperative venoarterial extracorporeal membrane oxygenation versus cardiopulmonary bypass during lung transplantation. Ann Thorac Surg. 2014; Dec; 98(6): 1936-42.
Markovetz, MR, Corcoran, TE, Locke, LW, Myerburg, MM, Pilewski, JM, Parker, RS. A Physiologically-Motivated Compartment-Based Model of the Effect of Inhaled Hypertonic Saline on Mucociliary Clearance and Liquid Transport in Cystic Fibrosis. PLoS One. 2014; Nov 19;9(11): e111972.
Zemke, AC, Shiva, S, Burns, JL, Moskowitz, SM, Pilewski, JM, Gladwin, MT, Bomberger, JM. Nitrite modulates bacterial antibiotic susceptibility and biofilm formation in association with airway epithelial cells. Free Radic Biol Med. 2014; Sep 16: S0891-5859(14)00402-X.
Locke, LW, Myerburg, MM, Markovetz, MR, Parker, RS, Weber, L, Czachowski, MR, Harding, TJ, Brown, SL, Nero, JA, Pilewski, JM, Corcoran, TE. Quantitative Imaging of Airway Liquid Absorption in Cystic Fibrosis. Eur Resp J. 2014; Apr 17.
Corcoran, TE, Thomas, KM, Garoff, S, Tilton, RD, Przybycien, TM, Pilewski, JM. Imaging the post deposition dispersion of an inhaled surfactant aerosol. J Aerosol Medicine Pulm Drug Del. 2012; Mar 6.
Sponsored Research/Activities
Title: CFF Lung Transplant Consortium
Role: Co-Investigator
Funding Agency: Cystic Fibrosis Foundation Therapeutics, Inc.
Grant Number: RES
Start Year: 2020
End Year: 2022
Title: Cadaveric Donor Lung and Bone Marrow Transplantation in Immunodeficiency Diseases
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: U01 AI125050
Start Year: 2016
End Year: 2021
Title: Building Multilevel Models of Therapeutic Response in the Lungs
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: U01 HL131046
Start Year: 2016
End Year: 2020
Title: Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC)
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: U01 HL128954
Start Year: 2015
End Year: 2020
Title: Pitt CF Research Development Program
Role: Core Director
Funding Agency: Cystic Fibrosis Foundation
Start Year: 2019
End Year: 2023
Notable Achievements
Harry Shwachman Clinical Investigator Award, Cystic Fibrosis Foundation, 1995-1998
Best Doctors in America, Northeast Edition, 1996
Best Doctors in America, 1999-2016
Breath of Life Award, Western Pennsylvania Chapter of Cystic Fibrosis Foundation, 2002
UPMC Award for Commitment and Excellence in Service (ACES), 2013

Division Websites

Cardiology

Endocrinology and Metabolism

Gastroenterology, Hepatology and Nutrition

General Internal Medicine

Geriatric Medicine
Hematology/Oncology

Infectious Diseases

Pulmonary, Allergy and Critical Care Medicine

Renal-Electrolyte

Rheumatology and Clinical Immunology

Contact

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Phone:  412-648-9636
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