Department of Medicine

Department of Medicine

  Division of Gastroenterology, Hepatology and Nutrition

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photo Satdarshan (Paul) Singh Monga, MD

Professor of Pathology and Medicine

Endowed Chair for Experimental PAthology

Vice Chair and Chief of the Division of Experimental Pathology

Assistant Dean & Co-Director of the Medical Scientist Training Program

Director, Pittsburgh Liver Research Center

Director of Cellular Approaches to Tissue Engineering & Regeneration (CATER) Program


Phone: 412-648-8842

Office: University of Pittsburgh Department of Pathology
200 Lothrop Street, S422 BST
Pittsburgh, PA 15261
Phone: 412-648-8842
Fax: 412-648-1916
Administrative Assistant:
Amanda Bytzura
Address: S414 BST
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-648-8842
Fax: 412-648-1916
Education and Training
F.Sc, MM Modi College, Patiala, Punjab, India, 1988
MD, Dayanand Medical College & Hospital, University, Chandigarh, India, 1992
Research Interest
A Professor of Pathology and Medicine, Dr. Monga's laboratory is focused on understanding the molecular mechanisms of liver growth and development in health and disease, especially trying to address the molecular basis of liver development, growth, regeneration and cancer. Several signaling pathways have been identified to direct such events including the Wnt/ß-catenin, HGF/Met, PDGFR? and others.

A significant focus in Dr. Monga's laboratory is targeting the HCC pathway and others, which are normally upregulated during liver development at the time of peak proliferation and stem cell renewal, as a novel therapeutic measure.

In addition, various animal models have been generated in Dr. Monga's laboratory, which conditionally overexpress or show lack of expression of important genes such as ß-catenin and others, which are in the process of being studied for the role of canonical Wnt signaling in additional liver diseases such as alcoholic liver disease, nonalcoholic fatty liver disease, glucose metabolism and others.

The Monga lab is focused on understanding the molecular and cellular basis of normal liver characteristics such as development, regeneration, metabolism and growth as well as liver pathologies such as neoplasms (HCC and hepatoblastoma), fibrosis, cirrhosis, alcoholic liver disease, non-alcoholic fatty liver disease, and others. This research focus incorporates studies on cell proliferation, adhesion, differentiation, invasion, apoptosis, metabolism, and on stem cells in adult, fetal, and embryonic livers.
For my complete bibliography, Click Here.
Selected Publications:
Tao J, Xu E, Zhao Y, Singh S, Li X, Couchy G, Chen X, Zucman-Rossi J, Chikina M, Monga SP. Modeling a Human HCC Subset in Mice Through Co-Expression of Met and Point-Mutant ß-Catenin. Hepatology. 2016.
Monga SP. ß-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis. Gastroenterology. 2015; 148(7): 1294-310.
Delgado E, Okabe H, Preziosi M, Russell JO, Alvarado TF, Oertel M, Nejak-Bowen KN, Zhang Y, Monga SP. Complete response of Ctnnb1-mutated tumours to ß-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model. Journal of Hepatology. 2015; 62(2): 380-7.
Tao J, Calvisi DF, Ranganathan S, Cigliano A, Zhou L, Singh S, Jiang L, Fan B, Terracciano L, Armeanu-Ebinger S, Ribback S, Dombrowski F, Evert M, Chen X, Monga SP. Activation of ß-catenin and Yap1 in human hepatoblastoma and induction of hepatocarcinogenesis in mice. Gastroenterology. 2014; 147(3): 690-701.
Yang J, Mowry LE, Nejak-Bowen KN, Okabe H, Diegel CR, Lang RA, Williams BO, Monga SP. ß-catenin signaling in murine liver zonation and regeneration: a Wnt-Wnt situation!. Hepatology. 2014; 60(3): 964-76.
Fanti M, Singh S, Ledda-Columbano GM, Columbano A, Monga SP. Tri-iodothyronine induces hepatocyte proliferation by protein kinase A-dependent ß-catenin activation in rodents. Hepatology. 2014; 59(6): 2309-20.
Awuah PK, Nejak-Bowen KN, Monga SP. Role and regulation of PDGFRa signaling in liver development and regeneration. American Journal of Pathology. 2013; 182(5): 1648-58.
Wickline ED, Awuah PK, Behari J, Ross M, Stolz DB, Monga SP. Hepatocyte ?-catenin compensates for conditionally deleted ß-catenin at adherens junctions. Journal of Hepatology. 2011; 55(6): 1256-62.
Tan X, Yuan Y, Zeng G, Apte U, Thompson MD, Cieply B, Stolz DB, Michalopoulos GK, Kaestner KH, Monga SP. Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development. Hepatology. 2008; 47(5): 1667-79.
Tan X, Behari J, Cieply B, Michalopoulos GK, Monga SP. Conditional deletion of beta-catenin reveals its role in liver growth and regeneration. Gastroenterology. 2006; 131(5): 1561-72.
Notable Achievements
Secretary Treasurer, American Society of Investigative Pathology, 2016
Recipient of the Robert E. Stowell Lectureship, UC Davis, Department of Pathology, 2016
Chair: Liver Workshop, Experimental Biology (EB), San Diego, CA, 2016
Editor-in-Chief, Gene Expression: The Journal of Basic Liver Research (Cognizant Communication), 2015-present
Medical Student Research Mentoring Merit Award, University of Pittsburgh, School of Medicine, 2015
Chair: Liver Symposia, Experimental Biology (EB), Boston, MA, 2015
Associate Editor, Journal of Hepatology, 2014-2016
Program Chair-Elect, American Society of Investigative Pathology, 2014-2017
Outstanding Investigator Award, American Society of Investigative Pathology, 2014