Department of Medicine

Department of Medicine

  Division of Endocrinology and Metabolism




Administrative/Research Office:
(412) 648-9770

Patient/Clinical Inquiries:
(412) 586-9700



Research Staff

Steven J Anthony, MS

Title:  Research V, Exercise Physiologist
Phone: 412-692-4150
Office: NW 8th floor MUH, room NW812


Degree:  MS, Exercise Physiology/Cardiac and Pulmonary Rehabilitation

Research Interest: Metabolic testing, max and submax exercise testing, with EKG
and gas collection, resting energy expenditure, body composition (Bod Pod and DEXA scans)



Nikolaos Dedousis

Title: Technician IV
Phone: 412-648-2164
Location: BST W1026



Degree: Associate in Engineering Science


Michael Ewing

Title:  Res Tech IV
Fax: 412-648-3290
Location: W1026-2B BST


Degree: B.S. in Biology from University of Toledo 
               Ed.M. Science Education from University of Pittsburgh

Selected Publications:

Hidvegi TMukherjee AEwing MKemp CPerlmutter DH. "The role of autophagy in alpha-1-antitrypsin deficiency."  Methods Enzymol. 2011;499:33-54.

Hidvegi T, Ewing M, Hale P, Dippold C, Beckett C, Kemp C, Maurice N, Mukherjee A, Goldbach C, Watkins S, Michalopoulos G, Perlmutter DH.  "An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis."  Science. 2010 Jul 9;329(5988):229-32

Li J1, Pak SC1, O'Reilly LP1, Benson JA1, Wang Y1, Hidvegi T1, Hale P1, Dippold C1, Ewing M1, Silverman GA2, Perlmutter DH.  "Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of alpha-1-antitrypsin deficiency."  PLoS One. 2014 Jan 31;9(1)

Hidvegi TStolz DBAlcorn JFYousem SAWang JLeme ASHoughton AMHale PEwing MCai HGarchar EAPastore NAnnunziata PKaminski NPilewski JShapiro SDPak SCSilverman GABrunetti-Pierri NPerlmutter DH. "Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy."  J Biol Chem. 2015 Dec 11;290(50):29742-57.


Brydie Huckestein

Title:  Laboratory Specialist
Phone: 412-648-9770
Fax: 412-648-3290
Location: W1026-3A




Degree: BS

Selected Publication: "Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice." Costa DK1, Huckestein BR2, Edmunds LR2, Petersen MC3, Nasiri A1, Butrico GM1, Abulizi A1, Harmon DB2, Lu C2, Mantell BS2, Hartman DJ4, Camporez JP1, O'Doherty RM5, Cline GW1, Shulman GI6, Jurczak MJ7.

Notable Acheivements: Guided Poster Session at the ADA


Polly Elizabeth Mattila

Title:  Research Scientist/ Division Scientific Manager
Fax: 412-648-3290
Location: W1026-2A


Degree: PhD

Education: BS., University of Minnesota, Twin Cities, 1994
                    PhD, University of Minnesota, Twin Cities, 2006

Postdoctoral Associate, Immunology/Alveolar Macrophages,
University of Pittsburgh, 2006
Postdoctoral Fellow, Cell Biology/Apical Protein Trafficking,
University of Pittsburgh, 2007
Research Instructor, Acute Kidney Injury and Repair, Division of Renal-Electrolyte, University of Pittsburgh, 2011

Research Interest:
Dr. Mattila is interested in understanding how nutritional status and obesity lead to changes in cell signaling pathways that result in dysregulation of lipid and glucose metabolism.

Selected Publications:

  1. Walcheck B., Leppanen A., Cummings RD., Knibbs RN., Stoolman LM., Alexander SR., Mattila PE., and McEver RP.  "The Monoclonal Antibody CHO-131 Binds to a Core 2 O-glycan Terminated with Sialyl-Lewis x, which is a Functional Glycan Ligand for P-selectin."  Blood  2002 Jun 1; 99(11): 4063-9.
  2. Mattila, PE., Green, CE., Schaff, U., Simon, SI., and Walcheck, B.  "Cytoskeletal Interactions Regulate Inducible L-selectin Clustering."   Am J Physiol., Cell Physiol. 2005 Aug; 289(2): C323-32.
  3. Walcheck, B., Herrera, AH., St. Hill, C., Mattila, PE., Whitney AR., and FR. DeLeo.  "ADAM17 Activity During Human Neutrophil Activation and Apoptosis."  Eur. J. Immunol.  2006 Apr. 36(4): 968-76.
  4. Schaff, U.*, Mattila, PE.*, Simon, SI., and B. Walcheck. "Neutrophil adhesion to E-selectin under shear promotes the redistribution and coclustering of ADAM17 and its proteolytic substrate L-selectin." J Leukoc Biol. 2008 Jan;83(1):99-105.
  5. Mattila, PE., Metz, AE., Rapaka, RR., Bauer, LD, and C. Steele."Dectin-1 Fc Targeting of Aspergillus fumigates beta-glucans Augments Innate Defense Against Invasive Pulmonary Aspergillosis".   Antimicrob Agents Chemother. 2008 Mar;52(3):1171-2.   
  6. Mattila, PE.*, Kinlough, CL.*, Bruns, JR., Weisz, OA, and RP. Hughey. "MUC1 Transits Apical Endosomes Along the Biosynthetic Pathway." Biol Chem.  2009 Jul. 390(7): 551-6.
  7. Folsch, H., Mattila, PE., and OA. Weisz. "Taking the Scenic Route: Biosynthetic Traffic to the Plasma Membrane in Polarized Epithelial Cells." Traffic 2009 Aug. 10(8): 972-81.
  8. Kinlough, CL., Poland, PA., Gendler, SJ., Mattila, PE., Mo, D., Weisz, OA.,  and RP. Hughey.  "Core-glycosylated mucin-like repeats from MUC1 are an apical targeting signal."  J. Biol. Chem. 2011 Nov 11: 286(45): 39072-81.
  9. Mattila, P.E., Youker, RT, Mo, D., Cresawn, K.O., Bruns, J.R., Hughey, R.P., Ihrke, G., and O.A. Weisz. "Multiple Biosynthetic Trafficking Routs for Apically Secreted Proteins in MDCK Cells." Traffic 2012 Mar; 13(3):433-42.
  10. Mattila, P.E., Raghavan, V., Rhaibi, Y., and O. A. Weisz. "Rab11a-positive compartments in proximal tubule cells sort fluid phase and membrane cargo."  Am JPhysiol-Cell Physiol  2014 306 (5):C441-9.

Sponsored Research/Activities:

Title: Endolyn/CD164 and CXCR4 Function in Kidney Repair
Role: Principal Investigator
Funding Agency: American Heart Association
Grant Number: 12SDG1240003
Start Year: 2012
End Year: 2016

Title: Intracellular Route of Secreted Apical Protein in Renal Epithelial Cells
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: 5 F32 DK082109-02
Start Year: 2008
End Year: 2011

Title: Endolyn Modulation of CXCR4 Signaling in Recovery from Kidney Injury
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: Pilot and Feasibility projects, Pittsburgh Center for Kidney Research, (P30DK079307)
Start Year: 2011
End Year: 2013


Ian J. Sipula

Title:  Senior Research Specialist
Phone: 412-648-9770
Location: W1026 BST




Degree: Bachelors of Science

Education: University of Vermont – Mechanical Engineering
                    University of Pittsburgh – Psychology


Ashlee Wood

Title:  Research Technician
Location: BST W 1026-3




Degree: Biology (BA), Biomedical Science (MS)

Education: Thiel College, Biology BA (2012),
                    Drexel University, Biomedical Science MS (2014)

Research Interest: Intracellular lipid metabolism in the metabolic syndrome