Department of Medicine

Department of Medicine

  Division of Endocrinology and Metabolism

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photo Maja Stefanovic-Racic, MD, PhD

Assistant Professor of Medicine

Director, EDM Fellowship Training Program


Phone: 412-648-7009

Office: Falk Medical Building, Suite 571
3601 Fifth Avenue
Pittsburgh, PA 15213
Phone: 412-648-7009
Fax: 412-648-3290
Administrative Assistant:
Lorrie Fox
Address: Falk Medical Building
3601 Fifth Avenue
Pittsburgh, PA 15213
Phone: 412-586-9884
Fax: 412-586-9726
Education and Training
MD, University of Belgrade School of Medicine, Serbia, 1989
PhD, University of Pittsburgh, 1996
Postdoctoral Fellow, Dept. of Orthopaedic Res., University of Pittsburgh, 1998
Internal Medicine Resident, University of Pittsburgh Medical Center, 2001
Fellowship, Endocrinology & Metabolism, University of Pittsburgh Medical Center, 2004
Fellowship, Endocrinology, University of Pittsburgh Medical Center, 2004
Research Interest
Dr. Stefanovic's interests are related to mechanisms involved in development of non-alcoholic fatty liver disease(NAFLD), which is associated with obesity, insulin resistance and type 2 diabetes. More specifically, she has been focusing on the role of immune system, both innate and adaptive, in transitioning from simple liver steatosis (fatty liver) to liver inflammation (nonalcoholic steatohepatitis or NASH). Results of experiments performed in animal models of obesity showed that one of immune cell type, called dendritic cells, plays a particularly important role in liver inflammation. The most intriguing question related to this finding is whether manipulation of dendritic cells could reduce inflammation in liver and other tissues in obesity, leading to a reduced risk of developing insulin resistance and diabetes.
Clinical Interest
As a general endocrinologist, Dr. Stefanovic treats a variety of endocrinologic conditions, with a special interest in diabetes and lipid disorders.
Educational Interest
Dr. Stefanovic is involved in education of medical students, Internal Medicine residents and Endocrinology fellows.
For my complete bibliography, Click Here.
Selected Publications:
Coen PM, Hames KC, Leachman EM, DeLany JP, Ritov VB, Menshikova EV, Dube JJ, Stefanovic-Racic M, Toledo FG, Goodpaster BH. Reduced skeletal muscle oxidative capacity and elevated ceramide but not diacylglycerol content in severe obesity. Obesity. 2013; Epub ahead of print.
He J, Gao J, Xu M, Ren S, Stefanovic-Racic M, O'Doherty RM, Xie W. PXR ablation alleviates diet-induced and genetic obesity and insulin resistance in mice. Diabetes. 2013; 62: 1876-1887.
Behari, J, Li, H, Liu, S, Stefanovic-Racic, M, Alonso, L, O'Donnell, CP, Shiva, S, Singamsetty, S, Watanbe, Y, Singh, VP, Liu, Q. Beta-Catenin links metabolic zonation with lipid metabolism and diet-induced obesity in mice. American Journal of Pathology. 2014; 184: 3284-3298.
Coen, P. M., Menshikova, E. V., Distefano, G., Zheng, D., Tanner, C. J., Standley, R. A., Helbling, N. L., Dubis, G. S., Ritov, V. B., Xie, H., Desimone, M. E., Smith, S. R., Stefanovic-Racic, M., Toledo, F. G., Houmard, J. A., Goodpaster, B. H. Exercise and weight loss improve muscle mitochondrial respiration, lipid partitioning and insulin sensitivity following gastric bypass surgery. Diabetes. 2015; 64: 3656-3658.
Schoiswohl, G, Stefanovic-Racic, M, Menke, MN, Wills, RC, Surlow, BA, Basantani, MK, Sitnick, MT, Cai, L, Yazbeck, CF, Stolz, DB, Pulinilkunnil, T, O'Doherty, RM, Kershaw, EE. Impact of reduced ATGL-mediated adipocyte lipolysis on obesity-associated insulin resistance and inflammation in male mice. Endocrinology. 2015; 156: 3610-3624.
Distefano, G., Standley, R. A., Dube, J. J., Carnero, E. A., Ritov, V. B., Stefanovic-Racic, M., Toledo, F. G., Piva, S. R., Goodpaster, B. H., Coen, P. M. Chronological age does not influence ex-vivo mitochondrial respiration and quality control in skeletal muscle. J Gerontol A Biol Sci Med Sci. 2016; Epub ahead of print.
Dube, J. J., Broskey, N. T., Despines, A. A., Stefanovic-Racic, M., Toledo, F. G., Goodpaster, B. H., Amati, F. Muscle characteristics and substrate energetics in lifelong endurance athletes. Med Sci Sports Exerc. 2016; 48: 472-480.
Hames, K. C., Coen, P. M., King, W. C., Anthony, S. J., Stefanovic-Racic, M., Toledo, F. G., Lowery, J. B., Helbling, N. L., Dube, J. J., DeLany, J. P., Jakicic, J. M., Goodpaster, B. H. Resting and exercise energy metabolism in weight-reduced adults with severe obesity. Obesity. 2016; 24: 1290-1298.
Krishna, KB, Stefanovic-Racic, M, Dedousis, N, Sipula, I, O'Doherty, RM. Similar degree of obesity induced by diet or aging cause strikingly different immunologic and metabolic outcomes. Physiological Reports. 2016; Epub ahead of print.
Sponsored Research/Activities
Title: Dendritic Cells and Obesity
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK102839
Start Year: 2015
End Year: 2019