Department of Medicine

Department of Medicine

  Division of Cardiology

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photo Ravi Ramani, MD

Assistant Professor of Medicine

Director, UPMC Integrated Heart Failure Program


Phone: 412-647-8711

Office: Cardiovascular Institute
200 Lothrop Street, Scaife Hall, Room S-569
Pittsburgh, PA 15213
Phone: 412-647-8711
Fax: 412-647-5724
Administrative Assistant:
Alena Dvoryanchikova
Phone: 412-647-7592
Education and Training
MBBS, Armed Forces Medical College, Pune, India, 1994
Residency, RML Hospital, New Delhi, India, 1996
Residency (Internal Medicine), Montefiore Medical Center, Bronx, NY, 1999
Cardiology Fellowship, UPMC Heart and Vascular Institute, Pittsburgh PA, 2003
Research Interest
Dr. Ramani’s research studies the mechanisms of myocardial recovery after development of heart failure, through the use of mechanical circulatory support. It focuses on reversible and irreversible alterations in pathways of myocyte hypertrophy and fibrosis, with emphasis on microRNA signatures of recovery potential.
Clinical Interest
UPMC has embraced telemedicine as a primary instrument to deliver high-value care to the population in its care. As the physician leading this effort, Dr. Ramani has designed and implemented standardized processes to identify, engage and manage at-risk Heart Failure patients, employing telemonitoring platforms to deliver proactive, efficient, patient-centered care. He employs teleconsulting to evaluate complex cases at remote locations, including with UPMC Palermo, Italy.
Educational Interest
Dr. Ramani is responsible for the Heart Failure core curriculum for medical students, residents and fellows. He also has an advisory role in the Heart Failure curriculum for the School of Nursing, and conducts continuing medical education classes for cardiologists.
For my complete bibliography, Click Here.
Selected Publications:
Bhama JK, Shulman J, Bermudez CA, Bansal A, Ramani R, Teuteberg JJ, Shullo M, McNamara DM, Kormos FL, Toyoda Y. Heart transplantation for adults with congenital heart disease: results in the modern era. J Heart Lung Transplant. 2013; 32(5): 499-504.
McTiernan CF, Ramani R, Burkhead B, McNamara D. The methionine 196 arginine polymorphism of the TNF receptor 2 gene (TNFRSF1B) is not associated with worse outcomes in heart failure. Cytokine. 2012; 60(3): 838-42.
Ramani R, Vela D, Segura A, McNamara D, Lemster B, Samarendra V, Kormos R, Toyoda Y, Bermudez C, Frazier OH, Moravec CS, Gorcsan J 3rd, Taegtmeyer H, McTiernan CF. A micro-ribonucleic acid signature associated with recovery from assist device support in 2 groups of patients with severe heart failure. J Am Coll Cardiol. 2011; 58(22): 2270-8.
Ramani R, Nilles K, Gibson G, Burkhead B, Mathier M, McNamara D, McTiernan CF. Tissue inhibitor of metalloproteinase-2 gene delivery ameliorates postinfarction cardiac remodeling. Clin Transl Sci. 2011; 4(1): 24-31.
Rudolph V, Rudolph TK, Schopfer FJ, Boancci G, Woodcock SR, Cole MP, Baker PR, Ramani R, Freeman BA. Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusion. Cardiovasc Res. 2010; 85(1): 155-66.
Banerjee SK, Ramani R, Saba S, Rager J, Tian R, Mathier MA, Ahmad F. A PRKAG2 mutation causes biphasic changes in myocardial AMPK activity and does not protect against ischemia. Biochem Biophys Res Commun. 2007; 360(2): 381-7.
Ramani R, Mathier M, Wang P, Gibson G, Tögel S, dawson J, Bauer A, Alber S, Watkins SC, McTiernan CF, Feldman AM. Inhibition of tumor necrosis factor receptor-1-mediated pathways has beneficial effects in a murine model of postischemic remodeling. Am J Physiol Heart Circ Physiol. 2004; 287(3): H1369-77.
Ramani R, Mathier M, Dawson J, McTiernan CF, Feldman AM. Assessment of infarct size and myocardial function in mice using transesophageal echocardiography. J Am Soc Echocardiogr. 2004; 17(6): 649-53.
Aravamudan B, Volonte D, Ramani R, Guysoy E, Lisanti MP, London B, Galbiati F. Transgenic overexpression of caveolin-3 in the heart induces a cardiomyopathic phenotype. Hum Mol Genet. 2003; 12(21): 2777-88.
McNamara DM, Holubkov R, Postava L, Ramani R, Janosko K, Mathier M, MacGowan GA, Muralil S, Feldman AM, London B. Effect of the Asp298 variant of endothelial nitric oxide synthase on survival for patients with congestive heart failure. Circulation. 2003; 107(12): 1598-602.
Sponsored Research/Activities
Title: Blended Collaborative Care for Heart Failure and Co-Morbid Depression
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL114016
Start Year: 2013
End Year: 2018
Notable Achievements
Young Investigator Award, Heart Failure Soc of America, 2002
National Talent Search Competition (India), Finalist, 1989