Department of Medicine

Department of Medicine

 Division of Renal-Electrolyte

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photo Evan C. Ray, MD, PhD


Phone: 412-802-3043

Office: A915 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Phone: 412-802-3043
Fax: 412-647-6222
Education and Training
B.A. Biochemistry, University of Colorado, 1996
MD, University of Pennsylvania School of Medicine, 2008
PhD, University of Pennsylvania School of Medicine, 2008
Internal Medicine Internship, Hospital of the University of Pennsylvania, 2009
Internal Medicine Residency, Hospital of the University of Pennsylvania, 2001
Nephrology Clinical Fellowship, University of Pittsburgh Medical Center, 2014
T32 Research Scholar-Renal Physiology, University of Pittsburgh School of Medicine, 2016
Research Interest
Dr. Ray is examining factors that regulate renal sodium excretion, with special focus on the epithelial sodium channel (ENaC). Using a combination of electrophysiology, animal modeling, and human clinical data he is exploring the roles played by ENaC in regulating sodium excretion and blood pressure in healthy and diseased kidneys. He is examining whether genetic polymorphisms in the genes encoding ENaC alter blood pressure. He is exploring the role of proteolytic activation of ENaC in vivo in normal physiology and in disease states, such as nephrotic syndrome. As ENaC is also expressed in the lung, colon, tongue, blood vessels and brain, he is examining what physiologic roles ENaC plays in sodium transport in these organ systems.
Clinical Interest
Dr. Ray is board certified in internal medicine and nephrology (kidney disorders) and has worked with patients with difficult to treat hypertension since 2014. In addition to his clinical work with patients with abnormal blood pressure, Dr. Ray works with patients with chronic kidney disease, many of whom have high blood pressure.
For my complete bibliography, Click Here.
Selected Publications:
Ray, E.C., Deutsch, C. A trapped intracellular cation modulates K+ channel recovery from slow inactivation. Journal of General Physiology. 2006; 128(2): 203-17.
Kozey Keadle, S., Lyden, K., Hickey, A., Ray, E.C., Fowke, J.H., Freedson, P.S., Matthews, C.E. Validation of a previous day recall for measuring the location and purpose of active and sedentary behaviors compared to direct observation. International Journal of Behavioral Nutrition and Physical Activity. 2014; 11: 12.
Ray, E.C., Kleyman, T.R. Cutting it out: ENaC processing in the human nephron. Journal of the American Society of Nephrology. 2015; 26(1)1-3.
Ray, E.C., Rondon-Berrios, H., Kleyman, T.R. Sodium retention and volume expansion in nephrotic syndrome: implications for hypertension. Advances in Chronic Kidney Disease. 2015; 22(3): 179-84.
Chen, J., Ray, E.C., Yates, M.E., Buck, T.M., Brodsky, J.L., Kinlough, C.L., Winarski, K.L., Hughey, R.P., Kleyman, T.R., Sheng, S. Functional Roles of Clusters of Hydrophobic and Polar Residues in the Epithelial Na+ Channel Knuckle Domain. Journal of Biological Chemistry. 2015; 290(41): 25140-50.
Ray, E.C., Abdel-Kader, K., Bircher, N., Rondon-Berrios, H. Case report: proximal tubule impairment following volatile anesthetic exposure. Physiological Reports. 2015; 3(9): e12560.
Sponsored Research/Activities
Title: Renal and Epithelial Biology Training Program
Role: Post Doctoral Associate
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: T32 DK061296
Start Year: 2013
End Year: 2018
Notable Achievements
Bausch and Lomb Honorary Science Award, 1992
Phi Beta Kappa,l University of Colorado at Boulder, 1995
Golden Key National Honor Society, 1996
Graduation Summa cum Laude, University of Colorado at Boulder, 1996
Medical Scientist Training Program Fellowship, University of Pennsylvania School of Medicine, 1999
MD-PhD Thesis Award, 2006 Research Day, University of Pennsylvania School of Medicine, 2006
Nominee, Paul F. Cranefield Student Award, Society of General Physiologists, 2006
NKF Mid-Atlantic Young Investigators's Forum Winner: Basic Sciences Research, 2016
NKF National Young Investigators Forum, 2nd Place Winner: Basic Sciences Research, 2016
UPMC Department of Medicine Research Day Winner, Post-Doctoral Bench Research, 2016