Department of Medicine
Faculty Profiles by Division

Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine

Faculty Profiles
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photo Jesus Tejero, PhD

Pulmonary, Allergy and Critical Care Medicine

Associate Professor of Medicine

Email: jet68@pitt.edu

Phone: 412-624-2651
Contact
Office: Starzl Biomedical Science Tower, E1228
200 Lothrop Street
Pittsburgh, PA 15261
 
Phone: 412-624-2651
Fax: 412-648-3046
E-mail: jet68@pitt.edu
Education and Training
Education
BS, Chemistry, University of Saragossa, Spain, 1998
PhD, Biochemistry, University of Saragossa, Spain, 2004
Research Interest
Dr. Tejero’s research is focused on the biology of heme proteins. His main research goals include: i) to understand and characterize the chemical and kinetic features of the reactions of nitrite with hemoglobin, myoglobin, cytoglobin and neuroglobin, ii) to elucidate the cytoprotective mechanisms of the six-coordinate globins neuroglobin and cytoglobin, and iii) the development of heme-based antidotes for carbon monoxide poisoning.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Amdahl, MB, Sparacino-Watkins, CE, Corti, P, Gladwin, MT, Tejero, J. Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b5/Cytochrome b5 Reductase/NADH System. Biochemistry. 2017; 56(30): 3993-4004.
Azarov, I, Wang, L, Rose, JJ, Xu, Q, Huang, XN, Belanger, A, Wang, Y, Guo, L, Liu, C, Ucer, KB, McTiernan, CF, O'Donnell, CP, Shiva, S, Tejero, J, Kim-Shapiro, DB, Gladwin, MT. Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning. Science Translational Medicine. 2016; 8(368): 368ra173.
Corti, P, Xue, J, Tejero, J, Wajih, N, Sun, M, Stolz, DB, Tsang, M, Kim-Shapiro, DB, Gladwin, MT. Globin X is a six-coordinate globin that reduces nitrite to nitric oxide in fish red blood cells. Proc Natl Acad Sci USA. 2016; In Press.
Tejero, J, Kapralov, AA, Baumgartner, MP, Sparacino-Watkins, C, Anthonymuthu, TS, Vlasova, II, Camacho, CJ, Gladwin, MT, Bayir, H, Kagan, VE. Peroxidase Activation of Cytoglobin by Anionic phospholipids: Mechanisms and Consequences. BBA-Mol Cell Biol L. 2016; 1861: 391-401.
Corti, P, Ieraci, M, Tejero, J. Characterization of zebrafish neuroglobin and cytoglobins 1 and 2: Zebrafish cytoglobins provide insights into the transition from six-coordinate to five-coordinate globins. Nitric Oxide. 2016; 53: 22-34.
Tejero, J, Sparacino-Watkins, CE, Ragireddy, V, Frizzell, S, Gladwin, MT. Exploring the mechanisms of the reductase activity of neuroglobin by site-directed mutagenesis of the heme distal pocket. Biochemistry. 2015; 54: 722-733.
Sparacino-Watkins, CE, Tejero, J, Gauthier, MC, Ragireddy, V, Thomas, J, Azarov, I, Wang, J, Merchant, B, Basu, P, Gladwin, MT. Nitrite reductase and NO synthase activity of the mitochondrial molybdopterin enzymes mARC (MOSC) 1 and 2. J Biol Chem. 2014; 289: 10345-10358.
Tejero, J, Basu, S, Helms, C, Hogg, N, King, SB, Kim-Shapiro, DB, Gladwin, MT. Low NO concentration-dependence of the reductive nitrosylation reaction of haemoglobin. J Biol Chem. 2012; 287: 18262-18274.
Tiso, M, Tejero, J, Basu, S, Azarov, I, Wang, X, Simplaceanu, V, Frizzell, S, Jayaraman, T, Geary, L, Shapiro, C, Ho, C, Shiva, S, Kim-Shapiro, DB, Gladwin, MT. Human neuroglobin functions as a redox regulated nitrite reductase. J Biol Chem. 2011; 286: 18277-18289.
Tejero, J, Biswas, A, Wang, ZQ, Page, RC, Haque, MM, Hemann, C, Zwejer, JL, Misra, S, Stuehr, DJ. Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase. J Biol Chem. 2008; 283: 33498-33507.
Sponsored Research/Activities
Title: Hemoglobin based drugs for the treatment of carboxyhemoglobinemia
Role: Principal Investigator
Funding Agency: Globin Solutions, Inc. / National Institute of Health
Grant Number: R42 ES031993
Start Year: 2020
End Year: 2022
Title: Hemoglobin based drugs for the treatment of carboxyhemoglobinemia
Role: Principal Investigator
Funding Agency: Globin Solutions, Inc. / National Institute of Environmental Health Sciences
Grant Number: R42 ES031993
Start Year: 2020
End Year: 2022
Title: Antidote for Inhaled CO Poisoning Based on Mutationally Engineered Neuroglobin
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL125886
Start Year: 2019
End Year: 2022
Title: Antidote for Inhaled CO Poisoning Based on Mutationally Engineered Neuroglobin
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL125886
Start Year: 2019
End Year: 2022
Title: CO Scavenging by Heme Containing Proteins - Studies of Kinetics, Stability, and Toxicity
Role: Principal Investigator
Funding Agency: Globin Solutions, Inc.
Grant Number: RES
Start Year: 2018
End Year: 2020
Title: Pulmonary arteriole occlusion by platelet-neutrophil micro-emboli in Acute Chest Syndrome
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL128297
Start Year: 2021
End Year: 2025
Title: Hemopexin as a therapy for acute chest syndrome in Sickle Cell Disease
Role: Co-Investigator
Funding Agency: CSL Behring GmbH
Grant Number: DRUG
Start Year: 2020
End Year: 2022
Title: Therapeutic Targeting of Vascular Subphenotypes of Lung Disease
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL103455
Start Year: 2016
End Year: 2021
Title: Therapeutic Targeting of Vascular Subphenotypes of Lung Disease
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL103455
Start Year: 2016
End Year: 2021

Division Websites

Cardiology

Endocrinology and Metabolism

Gastroenterology, Hepatology and Nutrition

General Internal Medicine

Geriatric Medicine
Hematology/Oncology

Infectious Diseases

Pulmonary, Allergy and Critical Care Medicine

Renal-Electrolyte

Rheumatology and Clinical Immunology

Contact

Department of Medicine
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3550 Terrace Street
Pittsburgh, PA 15261
Email:  chairoff@pitt.edu
Phone:  412-648-9636
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