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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Elena A. Goncharova, PhD

Associate Professor of Medicine

Email: eag59@pitt.edu

Phone: 412-648-8474

Contact
Office: Starzl Biomedical Science Tower, Rm 1259
200 Lothrop Street
Pittsburgh, PA 15261
 
Phone: 412-648-8474
Fax: 412-648-3046
E-mail: eag59@pitt.edu
Administrative Assistant:
Carla Monzo
Address: 200 Lothrop St. - BST E1240
Pittsburgh, PA 15261
Phone: 412-648-3181
Fax: 412-648-5980
Education and Training
Education
MS, Biochemistry, Moscow Lomonosov State University, 1993
PhD, Biology, Cardiology Research Center, Russian Academy of Sciences, 2000
Training
Post-doctoral Researcher, signal transduction, University of Pennsylvania School of Medicine, 2005
Research Interest
Dr. Goncharova’s research interests have focused on the molecular and cellular mechanisms regulating metabolism, proliferation, motility and survival of pulmonary vascular cells as it relates to the pathogenesis of pulmonary hypertension. Her current work specifically focuses on the roles of mammalian target of rapamycin (mTOR)and HIPPO signaling networks as a master-regulators of Vascular Smooth Muscle remodeling in Pulmonary Arterial Hypertension (PAH). Dr. Goncharova's lab uses human-derived tissues and cells, genetically modified mice and rodent animal models of PH to dissect new signaling events driving PAH pathogenesis, identify and test new molecular targets. Dr. Goncharova's lab also runs VMI Cell Processing Core (isolates, characterizes and biobanks pulmonary vascular cells from subjects with PAH and donor lungs) and Animal Hypoxic Core (provides the platform and technical support for hypoxia-based modeling of PH in rodents).
Educational Interest
2003-present
Mentoring of pre- and post-doctoral students, research fellows and junior faculties

2015-present
Graduate Faculty, University of Pittsburgh Cellular & Molecular Pathology Graduate Program

2015-present
Faculty, University of Pittsburgh Institute for Clinical Research Education

2015
Facilitator, pharmacology conference (GPCR drugs), Cellular and Pathologic Basis of Disease/Pharmacology course

2016-present
Small group leader, CLRES 2071 Research Design and Development seminar, Degree Granting Programs in Clinical Research, Grant Writing Course

2016
Lecturer, Principles of Pharmacology course

2016-present
Faculty mentor, First Experiences in Research Program

2017-present
Faculty mentor, The Pittsburgh Undergraduate Research Diversity Program (PURDiP)
Publications
For my complete bibliography, Click Here.
Selected Publications:
Pullamsetti SS, Savai R, Seeger W, Goncharova EA. Translational Advances in the field of Pulmonary Hypertension. From cancer biology to new PAH therapeutics: Targeting cell growth and proliferation signaling hubs. American Journal of Respiratory and Critical Care Medicine. 2017; 195: 425-437.
Pena A, Kobir A, Goncharov D, Goda A, Vanderpool R, Baust J, Chang B, Mora AL, Gorcsan J III, Goncharova EA. Pharmacological inhibition of mTOR kinase reverses right ventricle remodeling and improves right ventricle structure and function in rats. American Journal of Respiratory Cell and Molecular Biology. 2017; 57: 733-744.
Kudryashova TV, Goncharov DA, Pena A, Kelly N, Vanderpool R, Baust J, Kobir A, Shufesky W, Mora AL, Morelli AE, Zhao J, Ihida-Stansbury K, Chang B, DeLisser H, Tuder RM, Kawut SM, Silljé HHW, Shapiro S, Zhao Y, Goncharova EA. HIPPO-integrin linked kinase crosstalk controls self-sustaining proliferation and survival in pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine. 2016; 194(7): 866-877.
Kudryashova TV, Goncharov DA, Pena A, Ihida-Stansbury K, DeLisser H, Kawut SM, Goncharova EA. Profiling the role of mTOR in the vascular smooth muscle metabolome in pulmonary arterial hypertension. Pulmonary Circulation. 2015; 5(4): 667-680.
Goncharov DA, Kudryashova TV, Ziai H, Ihida-Stansbury K, DeLisser H, Krymskaya VP, Tuder RM, Kawut SM, Goncharova EA. mTORC2 coordinates pulmonary artery smooth muscle cell metabolism, proliferation and survival in pulmonary arterial hypertension. Circulation. 2014; 129(8): 864-874.
Goncharova EA, Goncharov DA, James ML, Atochina-Vasserman EN, Stepanova V, Hong S-B, Li H, Gonzales L, Baba M, Linehan WM, Gow AJ, Margulies S, Guttentag S, Schmidt L, Krymskaya VP. Folliculin controls lung alveolar enlargement and epiteliak cell survival through E-cadherin, LKB1, and AMPK. Cell Reports. 2014; 7(2): 412-423.
Goncharova EA, Goncharov DA, Fehrenbach M, Khavin I, Ducka B, Hino O, Colby TV, Merrilees MJ, Haczku A, Albelda SM, Krymskaya VP. Prevention of Alveolar Destruction and Airspace Enlargement in a Mouse Model of Pulmonary Lymphangioleiomyomatosis (LAM). Science Translational Medicine. 2012; 4(154): 154ra134.
Krymskaya VP, Snow J, Cesarone G, Khavin I, Goncharov DA, Lim PN, Veasey SC, Ihida-Stansbury K, Jones PL, Goncharova EA. mTOR is Required for Pulmonary Arterial Vascular Smooth Muscle Cell Proliferation Under Chronic Hypoxia. The FASEB Journal. 2011; 25(6): 1922-1933.
Goncharova EA, Goncharov DA, Li H, Pimtong W, Lu S, Khavin I, Krymskaya VP. mTORC2 is Required for Proliferation and Survival of TSC2-Null Cells. Molecular and Cellular Biology. 2011; 31(12): 2484-2498.
Sponsored Research/Activities
Title: TSC2 signaling in Pulmonary Arterial Hypertension
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL113178
Start Year: 2018
End Year: 2022
Title: Preclinical assessment of dimethyl fumarate (Tecfidera) as a novel therapeutic for SSC-PAH
Role: Principal Investigator
Funding Agency: Trustees of Boston University
Grant Number: 4500002337
Start Year: 2017
End Year: 2019
Title: Translational Studies for Identifying and Targeting Novel Pathways in Systemic Sclerosis Pathogenesis (Project 2)
Role: Co-Investigator
Funding Agency: National Institute of Arthristis, Muscoskel, & Skin Disease
Grant Number: P50 AR060780
Start Year: 2017
End Year: 2022
Title: HIPPO Signaling in Pulmonary Arterial Hypertension
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL130261
Start Year: 2016
End Year: 2020
Title: Evaluation of the Role of Gremlin 1, Activin A and PDGFRB in Pulmonary Hypertension
Role: Principal Investigator
Funding Agency: Regeneron Pharmaceuticals, Inc.
Grant Number: RES
Start Year: 2016
End Year: 2018
Title: Therapeutic Targeting of Vascular Subphenotypes of Lung Disease
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL103455
Start Year: 2016
End Year: 2021
Title: mTOR Coordinates Cell Metabolism, Growth and Survival in Pulmonary Hypertension
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL113178
Start Year: 2013
End Year: 2017
Title: Hemostasis and Vascular Biology Research Institute - Cell Processing Core-Goncharova
Role: Co-Investigator
Funding Agency: Hemophilia Center of Western PA
Start Year: 2013
End Year: 2028
Title: Hemostasis and Vascular Biology Research Institute-Goncharova
Role: Co-Investigator
Funding Agency: Institute for Transfusion Medicine
Start Year: 2013
End Year: 2028
Title: University of Pittsburgh Clinical and Translational Science Institute - Research Education Core
Role: Co-Investigator
Funding Agency: National Center for Advancing Translational Sciences
Grant Number: UL1 TR000005
Start Year: 2011
End Year: 2016
Notable Achievements
Reviewer, NIH/NHLBI ZRG1 CVRS G (02) M Pulmonary Diseases, 2014-
Scientist reviewer, Department of Defense (DoD) Congressionally Directed Medical Research Programs (CDMRP), 2011-
University of Pittsburgh VMI-HVI Innovator Award, 2014
LAM Foundation Francis G. Byrnes Conference Award, 2013
Penn Department of Medicine Robert Austrian Award in Bench Research, 2012
American Lung Association Biomedical Research Award, 2011
Gilead Sciences Research Scholars Award in Pulmonary Arterial Hypertension, 2010
ATS/LAM Foundation Research Award, 2008
Parker B. Francis Fellowship Award, 2008
LAM Foundation Fellowship Award, 2005