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Department of Medicine

Department of Medicine

  Division of Rheumatology and Clinical Immunology

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photo Larry W. Moreland, MD

Margaret Jane Miller Endowed Professor of Arthritis Research

Chief, Division of Rheumatology and Clinical Immunology

Email: morelandl@dom.pitt.edu

Phone: 412-383-8734

Contact
Office: 3500 Terrace Street
Pittsburgh, PA 15261
 
Phone: 412-383-8734
Fax: 412-648-8894
E-mail: morelandl@dom.pitt.edu
Administrative Assistant:
Lauren Ashley Zufall
Address: 3500 Terrace Street
BST S710
Pittsburgh, PA 15261
Email: laurenzufall@pitt.edu
Phone: 412-383-8734
Fax: 412-383-8864
Education and Training
Education
BS, West Liberty State College, 1979
MD, West Virginia University, 1983
Training
Internship (Internal Medicine), West Virginia University Medical Center, 1984
Residency (Internal Medicine), West Virginia University Medical Center, 1986
Chief Medical Residency, West Virginia University Medical Center, 1987
Fellowship,Rheumatology & Clinical Immunology, University of Alabama at Birmingham, 1990
Research Interest
Dr. Moreland's research interest is in translational research for diseases such as rheumatoid arthritis, vasculitis, lupus and seronegative spondyloarthropathies. He has extensive experience in clinical trials and long-term registries for patients with autoimmune diseases. Specific areas of interest are pathogenesis, biomarkers, and outcomes research. He has extensive collaborations with colleagues at the University of Pittsburgh as well as numerous investigators at other academic institutions. In addition to being the Rheumatology Division Chief, he is Director of the University of Pittsburgh and UPMC Rheumatoid Arthritis Center and Vasculitis Center.
Clinical Interest
Dr. Moreland is Director of the University of Pittsburgh and UPMC Rheumatoid Arthritis Center and Vasculitis Center. He has a special clinical interest in rheumatoid arthritis, vasculitis, lupus, gout and seronegative spondyloarthropathies.
Educational Interest
Dr. Moreland mentors Rheumatology fellows, medicine residents and medical students.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Carette, S., Hoffman, G.S., Khalidi, N.A., Koeing, C.L., Langford, C.A., McAlear, C.A., Monach, P.A., Moreland, L., Pagnoux, C., Seo, P., Warrington, K.J., Ytterberg, S.R., Merkel, P.A., Vasculitis Clinical Research Consortium (Moreland LW). Evaluation of damage in giant cell arteritis. Rheumatology (Oxford). 2018; 57(2): 322-328.
Lee, Y.C, Bingham, C.O. 3rd, Edwards, R.R., Marder, W., Phillips, K., Bolster, M.B., Clauw, D.J., Moreland, L.W., Lu, B., Wohlfahrt, A., Zhang, Z., Neogi, T. Association Between Pain Sensitization and Disease Activity in Patients with Rheumatoid Arthritis: A Cross-Sectional Study. Arthritis Care Res (Hoboken). 2018; 70(2): 197-204.
Boers, M., Singh, J.A., Cofield, S.S., Louis Bridges, S. Jr., Moreland, L.W., O'Dell, J.R., Wu, H., Leatherman, S., Curtis, J.R. A Novel Method to Combine Assessment of Benefit and Harm: OMERACT 3x3 Methodology Applied to Two Active Comparator Trials. Arthritis Care Res (Hoboken). 2018.
Birru Talabi, M., Clowse, M.E.B., Schwarz, E.B., Callegari, L.S., Moreland, L., Borrero, S. Family Planning Counseling for Women With Rheumatic Diseases. Arthritis Care Res (Hoboken). 2018; 70(2): 169-174.
Oommen, E., Hummel, A., Allmannsberger, L., Cuthbertson, D., Carette, S., Pagnoux, C., Hoffman, G.S., Jenne, D.E., Khalidi, N.A., Koening, C.L., Langford, C.A., McAlear, C.A., Moreland, L., Seo, P., Sreih, A., Ytterberg, S.R., Merkel, P.A., Specks, U., et al. IgA Antibodies to Myeloperoxidase in Patients with Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss). Clin Exp Rheumatol. 2017; 35 Suppl 103(1): 98-101.
Cascio, S., Medsger, T.A. Jr., Hawse, W.F., Watkins, S.C., Milcarek, C., Moreland, L.W., Lafyatis, R.A., Fuschiotti, P. 14-3-3z sequesters cytosolic T-bet, upregulating IL-13 levels in TC2 and CD8+ lymphocytes from patients with scleroderma. J Allergy Clin Immunol. 2017; S0091-6749(17): 31760-31768.
Langford, C.A., Cuthbertson, D., Ytterberg, S.R., Khalidi, N., Monach, P.A., Carette, S., Seo, P., Moreland, L.W., Weisman, M., Koening, C.L., Sreih, A.G., Spiera, R., McAlear, C.A., Warrington, K.J., Pagnoux, C., McKinnon, K., Forbess, L.J., et al. A Randomized, Double-Blind Trial of Abatacept (CTLA-4Ig) for the Treatment of Giant Cell Arteritis. Arthritis Rheumatol. 2017; 69(4): 837-845.
Birru Talabi, M., Mackey, R.H., Kuller, L.H., Dorman, J.S., Deane, K.D., Robinson, W.H., Walitt, B.T., Chang, Y., Holers, V.M., Liu, S., Moreland, L.W. Human Leukocyte Antigen Shared Epitope and Inflammation, Cardiovascular Disease, Cancer, and Mortality Among Postmenopausal Women in the Women's Health Initiative Rheumatoid Arthritis Study. Am J Epidemiol. 2017; 186(2): 245-254.
Langford, C.A., Cuthbertson, D., Ytterberg, S.R., Khalidi, N., Monach, P.A., Carette, S., Seo, P., Moreland, L.W., Weisman, M., Koening, C.L., Sreih, A.G., Spiera, R., McAlear, C.A., Warrington, K.J., Pagnoux, C., McKinnon, K., et al. A Randomized, Double-Blind Trial of Abatacept (CTLA-4Ig) for the Treatment of Takayasu Arteritis. Arthritis Rheumatol. 2017; 69(4): 846-853.
Hwang, Y.G., Wasan, A.D., Feng, J., Eng, H., Lyons, J., Fabio, A., Moreland, L.W. Lower ratings of pain intensity in older adults lead to underestimation of disease activity in patients with rheumatoid arthritis. Int J Clin Rheumatol. 2017; 12: 28-37.
Sponsored Research/Activities
Title: An International, Open Label, Randomized Controlled Trial Comparing Rituximab with Azathioprine as Maintenance Therapy in Relapsing ANCA-Associated Vasculitis (RITAXAREM)
Role: Principal Investigator
Funding Agency: University of Pennsylvania
Start Year: 2017
End Year: 2019
Title: Abatacept (CTLA4-lg) for the Treatment of Relapsing, Non-Severe, Granulomatosis with Polyangitis (Wegener's) (ABROGATE)
Role: Principal Investigator
Funding Agency: Cleveland Clinic
Start Year: 2015
End Year: 2019
Title: Central Pain Mechanisms, Pain Intensity and Drug Response in Rheumatoid Arthritis
Role: Principal Investigator
Funding Agency: Brigham and Women's Hospital, Inc./National Institute of Arthristis, Muscoskel, & Skin Disease
Grant Number: R01 AR064850
Start Year: 2015
End Year: 2017
Title: Live Cell Autoreactive B-cell Capture for Advanced Analytics in RA
Role: Principal Investigator
Funding Agency: University of Minnesota
Start Year: 2015
End Year: 2016
Title: Treatments Against RA and Effect on FDG PET CT: The Target Trial
Role: Principal Investigator
Funding Agency: Brigham and Women's Hospital, Inc./National Institute of Arthristis, Muscoskel, & Skin Disease
Grant Number: U01 AR068043
Start Year: 2015
End Year: 2016
Title: UPITT Rheumatoid Arthritis Combined Center (UPITT RACC)
Role: Principal Investigator
Funding Agency: National Institute of Arthristis, Muscoskel, & Skin Disease
Grant Number: UH2 AR067685
Start Year: 2014
End Year: 2017
Title: Vasculitis Clinical Research Consortium
Role: Principal Investigator
Funding Agency: University of Pennsylvania/National Institute of Arthristis, Muscoskel, & Skin Disease
Grant Number: U54 AR057139
Start Year: 2014
End Year: 2016
Title: Open Label Study to Evaluate Efficacy and Safety of Short-Term, Adjunctive Adrenocorticotropic Hormone (ACTH) Gel Therapy in Rheumatoid Arthritis
Role: Principal Investigator
Funding Agency: Questcor Pharmaceuticals, Inc.
Grant Number: DRUG
Start Year: 2013
End Year: 2017
Title: RITAZAREM: An International, Open Label, Randomized, Controlled Trial Comparing Rituximab with Azathioprine as Maintenance Therapy in Relapsing ANCA-Associated Vasculitis
Role: Principal Investigator
Funding Agency: University of Pennsylvania
Start Year: 2013
End Year: 2016
Title: RF, CCP, SSA and More? SSA and Other CTD Autoantibody's Prevalence in African-American Patients with Rheumatoid Arthritis (ASPIRE)
Role: Principal Investigator
Funding Agency: Pfizer Inc.
Start Year: 2013
End Year: 2015
Title: Vasculitis Clinical Research Consortium
Role: Principal Investigator
Funding Agency: University of Pennsylvania/National Institute of Arthristis, Muscoskel, & Skin Disease
Grant Number: U54 AR057319
Start Year: 2013
End Year: 2014
Title: Novel Methods for the Conduct of Clinical Trials
Role: Principal Investigator
Funding Agency: University of Pennsylvania/National Heart, Lung, & Blood Institute
Grant Number: R01 HL115041
Start Year: 2012
End Year: 2015
Title: Adaption and Validation of PROMIS for use in Vasculitis
Role: Principal Investigator
Funding Agency: University of Pennsylvania/National Institute of Arthristis, Muscoskel, & Skin Disease
Grant Number: R01 AR064153
Start Year: 2012
End Year: 2015
Title: Rheumatoid Arthritis Comparative Effectiveness Research (RACER) Longitudinal Extension Study
Role: Principal Investigator
Funding Agency: Genentech, Inc.
Start Year: 2010
End Year: 2016
Title: Concurrent Pilot Studies in Giant Cell Arthritis and Takayasu's Arthritis to Examine the Safety, Efficacy & Immunologic Effects of Abatacept (CTLA4Ig) in Large Vessel Vasculitis (AGATA)
Role: Principal Investigator
Funding Agency: Cleveland Clinic/National Institute of Health
Start Year: 2010
End Year: 2015
Title: Amyloldosis Research Anti-TNF Therapies
Role: Principal Investigator
Funding Agency: Pittsburgh Foundation
Start Year: 2008
End Year: 2014
Title: Pilot Study Using PainDetect in Rheumatoid Arthritis
Role: Co-Investigator
Funding Agency: Pfizer Inc.
Grant Number: RES
Start Year: 2016
End Year: 2018
Title: Type I Interferon and the Mechanism of TNF Antagonist in RA
Role: Co-Investigator
Funding Agency: Rheumatology Research Foundation
Start Year: 2015
End Year: 2016
Title: Microbubble Contrast-Enhanced Vascular Ultrasonography: A Novel Method of Detecting Large Vessel Vasculitis
Role: Co-Investigator
Funding Agency: Vasculitis Foundation
Start Year: 2014
End Year: 2017
Notable Achievements
American Society of Clinical Investigation (ASCI), 2001-Present
The Max Cooper Award for Research Excellence, UAB, 2002
West Liberty State College Alumni Association Wall of Honor, 2007
Margaret Jane Miller Endowed Professor for Arthritis Research Chair, University of Pittsburgh, 2007-Present
Top Doctors, Pitsburgh Magazine, 2012-Present