Department of Medicine

Department of Medicine



Research Pages


The University of Pittsburgh Department of Medicine is a formidable leader in cutting-edge research. Our basic scientists, clinical researchers, and clinicians work daily to make research discoveries that will positively impact the world’s healthcare.

Our numbers:

Our scientists, physician-scientists, and clinicians do the advanced research that is changing people’s lives—and furthering our understanding of science. The papers they publish in high-impact journals … the grants and training awards they receive, including five new T32s in fiscal year 2015-16 … are all reflections of our investigators’ skill, dedication, and commitment.

  • Latest High-Impact Publications
  • Latest Grants, $1 Million and Above

Lipid metabolic reprogramming in hepatic ischemia-reperfusion injury.
Monga SP.
Nat Med. 2018 Jan 9;24(1):6-7.
PMID: 29315298


PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals.
Wenzel SE, Tyurina YY, Zhao J, St Croix CM, Dar HH, Mao G, Tyurin VA, Anthonymuthu TS, Kapralov AA, Amoscato AA, Mikulska-Ruminska K, Shrivastava IH, Kenny EM, Yang Q, Rosenbaum JC, Sparvero LJ, Emlet DR, Wen X, Minami Y, Qu F, Watkins SC, Holman TR, VanDemark AP, Kellum JA, Bahar I, Bayır H, Kagan VE.
Cell. 2017 Oct 19;171(3):628-641.
PMID: 29053969


The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1.
Meijles DN, Sahoo S, Al Ghouleh I, Amaral JH, Bienes-Martinez R, Knupp HE, Attaran S2, Sembrat JC, Nouraie SM, Rojas MM, Novelli EM, Gladwin MT, Isenberg JS, Cifuentes-Pagano E, Pagano PJ.
Sci Signal. 2017 Oct 17;10(501).
PMID: 29042481


Temporal Relation Between Myocardial Fibrosis and Heart Failure With Preserved Ejection Fraction: Association With Baseline Disease Severity and Subsequent Outcome.
Schelbert EB, Fridman Y, Wong TC, Abu Daya H, Piehler KM, Kadakkal A, Miller CA, Ugander M, Maanja M, Kellman P, Shah DJ, Abebe KZ, Simon MA, Quarta G, Senni M, Butler J, Diez J, Redfield MM, Gheorghiade M.
JAMA Cardiol. 2017 Sep 1;2(9):995-1006.
PMID: 28768311


Medication-Assisted Treatment and Opioid Use Before and After Overdose in Pennsylvania Medicaid.
Frazier W, Cochran G, Lo-Ciganic WH, Gellad WF, Gordon AJ, Chang CH, Donohue JM.
JAMA. 2017 Aug 22;318(8):750-752.
PMID: 28829862


Ischemic Postconditioning During Primary Percutaneous Coronary Intervention: Is Smoker's Paradox in Play?
Olafiranye O.
JAMA Cardiol. 2017 Sep 1;2(9):1049-1050.
PMID: 28746713


Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy.
Pasi KJ, Rangarajan S, Georgiev P, Mant T, Creagh MD, Lissitchkov T, Bevan D, Austin S, Hay CR, Hegemann I, Kazmi R, Chowdary P, Gercheva-Kyuchukova L, Mamonov V, Timofeeva M, Soh CH, Garg P, Vaishnaw A, Akinc A, Sørensen B, Ragni MV.
N Engl J Med. 2017;377:819-28 August 31, 2017


Severe asthma in humans and mouse model suggests a CXCL10 signature underlies corticosteroid-resistant Th1 bias.
Gauthier M, Chakraborty K, Oriss TB, Raundhal M, Das S, Chen J, Huff R, Sinha A, Fajt M, Ray P, Wenzel SE, Ray A.
JCI Insight. 2017 Jul 6;2(13). [Epub ahead of print] JCI Insight. 2017


Differential requirements for myeloid leukemia IFN-γ conditioning determine graft-versus-leukemia resistance and sensitivity.
Matte-Martone C, Liu J, Zhou M, Chikina M, Green DR, Harty JT, Shlomchik WD.
J Clin Invest. 2017 Jun 30;127(7):2765-2776.
PMID: 28604385


A Hippo in the Fox(p3) house.
McGeachy MJ.
Nat Immunol. 2017 Jun 20;18(7):709-711.
PMID: 28632715


Regulation of the ubiquitylation and deubiquitylation of CREB-binding protein modulates histone acetylation and lung inflammation.
Wei J, Song S, Bowser RK, Khoo A, Zhang L, Jacko AM, Zhao Y, Zhao J.
Sci Signal. 2017 Jun 13;10(483).
PMID: 28611184


Accelerated Approval and Expensive Drugs - A Challenging Combination
Gellad WF, Kesselheim AS.
N Engl J Med. 2017 May 25;376(21):2001-2004.


IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice. 
Oriss TB, Raundhal M, Morse C, Huff RE, Das S, Hannum R, Gauthier MC, Scholl KL, Chakraborty K, Nouraie SM, Wenzel SE, Ray P, Ray A.
JCI Insight. 2017 May 18;2(10): e91019


Outcomes of acute leukemia patientstransplanted with naive T cell-depleted stem cell grafts.
Bleakley M, Heimfeld S, Loeb KR, Jones LA, Chaney C, Seropian S, Gooley TA,Sommermeyer F, Riddell SR, Shlomchik WD.
J Clin Invest. 2017 Apr 27:JCO2016694935.
PMID: 26053664 



PI: Sonya Borrero, MD, MS, Division of General Internal Medicine | Bio
Agency: NIMHD
Title: Developing and Testing a Decision Support Tool for Women Making Tubal Sterilization Decisions
Project timeline: 8/14/2017 – 4/30/2022
Direct Costs: $2,702,184
Indirect Costs: $847,599


PI: Margaret Ragni, MD, MPH, Division of Hematology/Oncology | Bio
Agency: NHLBI
Title: Von Willebrand Disease Minimize Menorrhagia (VWDMin) Trial
Project timeline: 9/1/2017 – 8/31/2022
Direct Costs: $2,425,589
Indirect Costs: $957,442


PI: Stephen Y. Chan, MD, PhD, Division of Cardiology | Bio
Agency: NHLBI
Title: Molecular Drivers of Vascular Stiffness and Metabolic Dysfunction in HIV-Induced Pulmonary Arterial Hypertension
Project timeline: 7/1/2017 – 6/30/2021
Direct Costs: $1,874,177
Indirect Costs: $567,690


PI: Sally E. Wenzel, MD, Division of Pulmonary, Allergy and Critical Care Medicine | Bio
Agency: NHLBI
Title: Type-2 or Not Type-2:  That is the (Therapeutic) Question
Project timeline: 9/23/2017 – 6/30/2023
Direct Costs: $1,787,755
Indirect Costs: $587,510


PI: James DeLany, PhD, Division of Endocrinology | Bio
Agency: NIDDK
Title: Dynamic PET Imaging in Skeletal Muscle and Adipose Tissue to Explore Mechanisms of Lower Peripheral Glucose Uptake in African American Women
Project timeline: 9/1/2017 - 6/30/2020
Direct Costs: $1,465,546
Indirect Costs: $492,518


PI: Sanjay A. Patel, MD, MS, Division of Pulmonary, Allergy and Critical Care | Bio
Agency: George Washington University / NIH
Title: Sleep Reading and CPAP Monitoring Center (SCC) to Support the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network Trial of Continuous Positive Airway
Project timeline: 10/1/2017 – 8/31/2024
Direct Costs: $1,443,975
Indirect Costs: $260,980


PI: Janet S. Lee, MD, Division of Pulmonary, Allergy and Critical Care | Bio
Agency: NHLBI
Title: Mechanisms of Host Protection Against Pathogen-Secreted Proteases in Acute Lung Injury
Project timeline: 8/1/2017 – 6/30/22
Direct Costs: $1,426,738
Indirect Costs: $797,886


PI: Walid Gellad, MD, MPH, Division of General Internal Medicine | Bio
Agency: NIDA
Title: Using Machine Learning to Predict Problematic Prescription Opioid Use and Opioid Overdose
Project timeline: 9/1/2017 – 6/30/2020
Direct Costs: $1,417,843
Indirect Costs: $357,422


PI: Alison Morris, MD, MS, Division of Pulmonary, Allergy and Critical Care Medicine | Bio
Agency: NHLBI
Title: Dysbiosis Impact on Lung Disease in HIV (DimpL) Study
Project timeline: 9/1/2017 – 5/31/2021
Direct Costs: $1,356,431
Indirect Costs: $540,535


PI: Ramon Bataller, MD, PhD, Division of Gastroenterology, Hepatology and Nutrition | Bio
Agency: NIAAA
Title: Molecular Subtypes for Targeted THerapies in Alcoholic Hepatitis
Project timeline: 6/21/2017 – 5/31/2018
Direct Costs: $1,106,524
Indirect Costs: $351,734


PI: Raju Reddy, MD, Division of Pulmonary, Allergy and Critical Care Medicine | Bio
Agency: NHLBI
Title: Airway epithelial Cell Farnesoid X Receptor in COPD Pathophysiology
Project timeline: 8/1/2017 – 6/30/2021
Direct Costs: $1,000,000
Indirect Costs: $562,709