Department of Medicine

University of Pittsburgh

Thomas R. Kleyman, MD
photo

Chief, Renal-Electrolyte Division

Professor of Medicine

Professor of Cell Biology and Physiology

Professor of Pharmacology
Office: A919 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
 
Phone: 412-647-3121
Fax: 412-648-9166
E-mail: kleyman@pitt.edu
Education
B.S., Syracuse University, 1973
M.D., Washington University, St. Louis, MO, 1978
M.A. (honoris causa), University of Pennsylvania, 1997
Training
Internal Medical Residency, Presbyterian Hospital, New York, 9999
Nephrology Fellowship, Presbyterian Hospital, New York, 9999
Area of Specialization/Research Interest  
Molecular and cellular studies of epithelial Na+ channels
Regulation of ion channels by mechanical forces
Regulation of ion channels by proteases
 
Profile
Cellular and molecular studies of epithelial Na+ channels: Recent work has focused on characterizing the structure of the channel’s pore, and on the identification of sites within the channel's extracellular domain that have key roles in the modulation of channel activity in response to extracellular factors, including Na+, divalent metal ions, and proteases. We are also examining mechanisms by which specific proteases, such as furin, regulate epithelial Na+ channels.

Regulation of ion channels by mechanical forces: We are examining mechanisms by which mechanical forces regulate epithelial Na+ channels and large conductance Ca2+ activated K+ channels.
Recent Grants
Title: Sodium Channel Biogenesis
Role: Co-Principal Investigator
Amount:
Funding Agency: NIDDK/NIH
Start Year: 2009
End Year: 2014
Title: Renal and Epithelial Biology Training Program
Role: Principal Investigator
Amount:
Funding Agency: NIDDK/NIH
Start Year: 2008
End Year: 2013
Title: Pittsburgh Center for Kidney Research
Role: Principal Investigator
Amount:
Funding Agency: NIDDK/NIH
Start Year: 2008
End Year: 2013
Title: Biomechanical Regulation of Renal Ion Channels
Role: Principal Investigator
Amount:
Funding Agency: NIDDK/NIH
Start Year: 2006
End Year: 2011
Title: Renal Na Channels: Structure-Function Studies
Role: Principal Investigator
Amount:
Funding Agency: NIDDK/NIH
Start Year: 2005
End Year: 2010
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