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Department of Medicine

Department of Medicine

 Division of Renal-Electrolyte

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photo Roderick J. Tan, MD, PhD

Email: tanrj@upmc.edu

Phone: 412-624-4008

Contact
Office: 3550 Terrace Street
828A Scaife Hall
Pittsburgh, PA 15261
 
Phone: 412-624-4008
Fax: 412-647-6222
E-mail: tanrj@upmc.edu
Education and Training
Education
BS, Georgetown University, 1999
M.D., University of Pittsburgh, 2007
Ph.D., University of Pittsburgh, 2007
Training
Residency, Medicine, University of Pittsburgh Medical Center, 2010
Fellowship, Renal-Electrolyte, University of Pittsburgh Medical Center, 2012
Research Interest
Dr. Tan is interested in unraveling the molecular mechanisms underlying the development of acute kidney injury and chronic kidney disease and fibrosis utilizing both in vivo and in vitro approaches. In particular, he is assessing novel ways in which the glomerular and tubular compartment cross-talk in disease, and how the Nrf2/Keap1 pathway can be leveraged to prevent CKD. He is also studying how the Wnt/beta-catenin pathway and matrix metalloproteinases affect renal injury..
Clinical Interest
AKI, CKD, Diabetic Nephropathy, Glomerulonephritis, Membranous Nephropathy
Educational Interest
Medical School Teaching
Graduate School Teaching
Publications
For my complete bibliography, Click Here.
Selected Publications:
Tan, R.J., Liu, Y. Macrophage-derived TGF-ß in renal fibrosis: not a macro-impact after all. American journal of physiology. Renal physiology. 2013; 305(6): F821-2.
Tan, R.J., Liu, Y. Arrestin(g) podocyte injury with endothelin antagonism. Journal of the American Society of Nephrology : JASN. 2014; 25(3): 423-5.
Zhou, D., Li, Y., Zhou, L., Tan, R,J., Xiao, L., Liang, M., Hou, F.F., Liu, Y. Sonic hedgehog is a novel tubule-derived growth factor for interstitial fibroblasts after kidney injury. Journal of the American Society of Nephrology : JASN. 2014; 25(10): 2187-200.
Tan, R.J., Zhou, D., Zhou,L, Liu, Y. Wnt/ß-catenin signaling and kidney fibrosis. Kidney international supplements. 2014; 4(1): 84-90.
Zhou, L., Li, Y., He, W., Zhou, D., Tan, R.J., Hou, F.F., Liu, Y. Mutual antagonism of Wilms' tumor 1 and ß-catenin dictates podocyte health and disease. Journal of the American Society of Nephrology : JASN. 2015; 26(3): 677-91.
Zhou, L., Li, Y., Hao, S., Zhou, D., Tan, R.J., Nie, J., Hou, F.F., Kahn, M., Liu, Y. Multiple genes of the renin-angiotensin system are novel targets of Wnt/ß-catenin signaling. Journal of the American Society of Nephrology : JASN. 2015; 26(1): 107-20.
Tan, R.J., Zhou, D., Xiao, L., Zhou, L., Li,Y., Bastacky, S.I., Oury, T.D., Liu,Y. Extracellular Superoxide Dismutase Protects against Proteinuric Kidney Disease. Journal of the American Society of Nephrology : JASN. 2015; 26(10): 2447-59.
Zhou, L., Mo, H., Miao, J., Zhou, D., Tan, R.J., Hou, F.F., Liu, Y. Klotho Ameliorates Kidney Injury and Fibrosis and Normalizes Blood Pressure by Targeting the Renin-Angiotensin System. The American journal of pathology. 2015; 185(12): 3211-23.
Zhou, D., Tan, R.J., Fu, H., Liu, Y. Wnt/ß-catenin signaling in kidney injury and repair: a double-edged sword. Laboratory investigation; a journal of technical methods and pathology. 2016; 96(2): 156-67.
Xiao, L., Zhou, D., Tan, R.J., Fu, H., Zhou, L., Hou, F.F., Liu, Y. Sustained Activation of Wnt/ß-Catenin Signaling Drives AKI to CKD Progression. Journal of the American Society of Nephrology : JASN. 2016; 27(6): 1727-40.
Sponsored Research/Activities
Title: Oxidative Stress in Chronic Kidney Disease
Role: Principal Investigator
Funding Agency: American Heart Association-National
Grant Number: FELLOW
Start Year: 2013
End Year: 2018
Title: Pittsburgh Center for Kidney Research -PILOT
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: P30 DK079307
Start Year: 2013
End Year: 2018
Notable Achievements
Frank J. Bruns Teaching Award, 2012
Young Physician-Scientist Award, The American Society for Clinical Investigation, 2016