Department of Medicine

Department of Medicine

 Division of Renal-Electrolyte

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photo Ankita Roy, PhD

Research Instructor


Phone: 412-648-9399

Phone: 412-648-9399
Education and Training
PhD, Max Planck Institute of Biophysics, Germany
MS, University of Calcutta, India
Visiting Fellow, NIEHS, National Institute of Health, USA
Postdoctoral Associate, University of Pittsburgh, Renal-Electrolyte, USA
Research Interest
Dr. Roy is examining molecular mechanisms by which aldosterone regulates the thiazide-sensitive NaCl cotransporter (NCC) via the WNK-SPAK/OSR1 pathway. She is also investigating how other physiologically relevant hormones such as insulin, vasopressin and angiotensin II activate NCC by recruiting specific WNK kinases, and how the cooperative E3 ligase DCNL4 regulates WNK kinase stability via the KLHL3/Cul3 complex.
For my complete bibliography, Click Here.
Selected Publications:
Roy, A., Al-Qusairi, L., Donnelly, B.F., Ronzaud, C., Marciszyn, A.L., Gong, F., Chang, O., Butterworth, M.B., Pastor-Soler, N.M., Hallows, K.R., Straub, P., Subramanya, A.R. Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action. Journal of Clinical Investigation. 2015; 125(9): 3433-48.
Roy, A., Goodman, J.H., Begum, G., Donnelly, D.F., Pittman, G., Weinman, E.J., Sun, D., Subramanya, A.R. Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing. American Journal of Physiology - Renal Physiology. 2015; 308(4): F366-76.
Roy, A., Al-bataineh, M.M., Pastor-Soler, N.M. Collecting duct intercalated cell function and regulation. Clinical Journal of the American Society of Nephrology. 2015; 10(2): 305-24.
Webb, T.N., Carrisoza-Gaytan, R., Montalbetti, N., Rued, A., Roy, A., Socovich, A.M., Subramanya, A.R., Satlin, L.M., Kleyman, T.R., Carattino, M.D. Cell-specific regulation of L-WNK1 by dietary K. American Journal of Physiology - Renal Physiology. 2016; 310(1): F15-26.
Al-Qusairi, L., Basquin, D., Roy, A., Stifanelli, M., Rajaram, R.D., Debonneville, A., Nita, I., Maillard, M., Loffing, J., Subramanya, A.R., Staub, O. Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC. American Journal of Physiology - Renal Physiology. 2016; 311(2): F330-42.
Buck, T.M., Plavchak, L., Roy, A., Donnelly, D.F., Kashlan, O.B., Kleyman, T.R., Subramanya, A.R., Brodsky, J.L. The Lhs1/GRP170 chaperones facilitate the endoplasmic reticulum-associated degradation of the epithelial sodium channel. Journal of Biological Chemisty. 2013; 288(25): 18366-80.
Donnelly, D.F., Needham, P.G., Snyder, A.C., Roy, A., Khadem, S., Brodsky, J.L., Subramanya, A.R. Hsp70 and Hsp90 multichaperone complexes sequentially regulate thiazide-sensitive cotransporter endoplasmic reticulum-associated degradation and biogenesis. Journal of Biological Chemistry. 2013; 288(18): 13124-35.
Roy, A. Membrane preparation and solubilization. Methods of Enzymology. 2015; 557: 45-56.
Sponsored Research/Activities
Title: The Role of Na/H Exchanger in Cerebral Ischemia
Role: Research Assistant
Funding Agency: National Institute of Neurological Disorder & Stroke
Grant Number: R01 NS048216
Start Year: 2016
End Year: 2021
Title: Characterization and Control of the Renal WNK1 Signaling Pathway
Role: Research Instructor
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK098145
Start Year: 2014
End Year: 2019