SCHOOL OF MEDICINE  |  PITT HOME  |  FIND PEOPLE  |  FIND A DOCTOR AT UPMC

Department of Medicine

Department of Medicine

 Division of Renal-Electrolyte

[Return To Index page]
photo Thomas R. Kleyman, MD

Chief, Renal-Electrolyte Division

Sheldon Adler Professor of Medicine

Professor of Cell Biology

Professor of Pharmacology and Chemical Biology

Email: kleyman@pitt.edu

Phone: 412-647-3121

Contact
Office: A919 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
 
Phone: 412-647-3121
Fax: 412-648-9166
E-mail: kleyman@pitt.edu
Administrative Assistant:
Carmela Londino
Address: A919 Scaife Hall
3550 Terrace Street
Phone: 412-647-3118
Education and Training
Education
BS, Syracuse University, 1973
M.D., Washington University, St. Louis, MO, 1978
M.A. (honoris causa), University of Pennsylvania, 1997
Training
Internal Medical Residency, Presbyterian Hospital, New York, 1981
Nephrology Fellowship, Presbyterian Hospital, New York, 1983
Research Interest
Dr. Kleyman is the Sheldon Adler Professor of Medicine and Chief of the Renal-Electrolyte Division at the University of Pittsburgh. He is also a Professor of Cell Biology, and of Pharmacology and Chemical Biology, and is the Director of the Pittsburgh Center for Kidney Research. Dr. Kleyman recently completed a term as the editor-in-chief of the American Journal of Physiology: Renal Physiology, and is currently the deputy editor-in-chief of Physiological Reports. He has served on numerous editorial boards and study sections. His work is currently supported by grants from the NIH, and he is the principal investigator of NIH T32 and T35 training grants and a George M. O’Brien Kidney Research Center. The Kleyman laboratory focuses on studies of Na and K channels that are found in epithelia. How are epithelial Na channels regulated by extracellular factors, including Na, shear stress, and proteases? What are the roles of epithelial Na channels in non-epithelial tissues? What are the roles on WNK kinases in facilitating adaptive changes in K channel expression in response to increased dietary K intake?
Educational Interest
Dr. Kleyman's main educational interests are focused on fluid and electrolyte Disorders.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Webb, TN, Carrisoza-Gaytan, R, Montalbetti, N, Rued, A, Roy, A, Socovich, AM, Subramanya, AR, Satlin, LM, Kleyman, TR, Carattino, MD. Cell Specific Regulation of L-WNK1 by Dietary K+. American Journal of Physiology. 2016; 310: F15-26.
Kashlan, OB, Blobner, BM, Zuzek, Z, Tolino, M, Kleyman, TR. Na+ inhibits the epithelial Na+ channel by binding to a site in an extracellular acidic cleft. Journal of Biological Chemistry. 2015; 290: 568-576.
Mukherjee, A, Mueller, GM, Kinlough, CL, Sheng, N, Wang, Z, Mustafa, SA, Kashlan, OB, Kleyman, TR, Hughey, RP. Cys-palmitoylation of the gamma subunit has a dominant role in modulating activity of the epithelial sodium channel. Journal of Biological Chemistry. 2014; 289: 14351-14359.
Chen, J, Kleyman, TR, Sheng, S. Gain-of-function variant of the human epithelial sodium channel. American Journal of Physiology. 2013; 304: F207-213.
Kashlan, OB, Blobner, BM, Zuzek, Z, Carattino, MD, Kleyman, TR. Inhibitory tract traps the epithelial Na+ channel in a low activity conformation. Journal of Biological Chemistry. 2012; 287: 20720-20726.
Kashlan, OB, Adelman, JL, Okumora, S, Hughey, RP, Kleyman, TR, Grabe, M. Constraint based, homology model of the extracellular domain of the epithelial Na+ channel alpha subunit reveals a mechanism of channel activation by proteases. Journal of Biological Chemistry. 2011; 286: 649-660.
Passero, CJ, Mueller, GM, Rondon-Berrios, H, Hughey, RP, Kleyman, TR. Plasmin activates epithelial Na+ channels by cleaving the ? subunit. Journal of Biological Chemisty. 2008; 283: 36586-36591.
Carattino, MD, Sheng, S, Bruns, JB, Pilewski, JM, Hughey, RP, Kleyman, TR. The epithelial Na+ channel is blocked by a peptide derived from proteolytic processing of its alpha subunit. Journal of Biological Chemistry. 2006; 281: 18901-18907.
Carattino, MD, Sheng, S, Kleyman,TR. Epithelial Na+ channels are activated by laminar shear stress. Journal of Biological Chemistry. 2004; 279: 4120-4126.
Hughey, RP, Bruns, JB, Kinlough, CL, Harkleroad, KL, Tong, Q, Carattino,MD, Johnson, JP, Stockand, JD, Kleyman, TR. Epithelial sodium channels are activated by furin-dependent proteolysis. Journal of Biological Chemistry. 2004; 279: 18111-18114.
Sponsored Research/Activities
Title: Maturation of K Transport in the Distal Nephron
Role: Principal Investigator
Funding Agency: Mt. Sinai Medical Center/National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK038470
Start Year: 2015
End Year: 2020
Title: Training in Renal, GI, Endocrine, and Epithelial Biology
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: T35 DK065521
Start Year: 2015
End Year: 2020
Title: Allosteric ENaC Regulation
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK098204
Start Year: 2014
End Year: 2019
Title: Pittsburgh Center for Kidney Research - Core A
Role: Associate Director
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: P30 DK079307
Start Year: 2013
End Year: 2018
Title: Biomechanical Regulation of Renal Ion Transporters
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R37 DK051391
Start Year: 2011
End Year: 2016
Title: Maturation of K Transport in the Distal Nephron
Role: Principal Investigator
Funding Agency: Mt. Sinai Medical Center/National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK038470
Start Year: 2010
End Year: 2015
Title: Training in Renal, GI, Endocrine, and Epithelial Biology
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: T35 DK065521
Start Year: 2010
End Year: 2015
Title: Sodium Channel Biogenesis
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK065161
Start Year: 2009
End Year: 2015
Title: Pittsburgh Center for Kidney Research
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: P30 DK079307
Start Year: 2008
End Year: 2013
Title: Renal and Epithelial Biology Training Program
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: T32 DK061296
Start Year: 2008
End Year: 2013
Title: Epithelial Na Channels: Structure-Function Studies
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK054354
Start Year: 1998
End Year: 2012
Notable Achievements
AHA Established Investigatorship Award, 1991
American Society for Clinical Investigation, 1996
Association of American Physicians, 2004
NIH MERIT Award, 2006
Ussing Award Lecture, American Physiological Society, 2008
Robert Schrier Lecture, American Society of Nephrology, 2009
Donald Seldin Lecture, American Heart Association, 2010
Sheldon Alder, MD Chair in Nephrology Research, 2011
Carl W. Gottschalk Distinguished Lectureship, American Physiological Society, 2015