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Department of Medicine

Department of Medicine

 Division of Renal-Electrolyte

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photo Anthony Kanai, PhD

Email: ajk5@pitt.edu

Phone: 412-624-1430

Contact
Office: A1224 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
 
Phone: 412-624-1430
Fax: 412-648-7197
E-mail: ajk5@pitt.edu
Education and Training
Education
PhD, University of Pittsburgh, 1992
Research Interest
Dr. Kanai’s lab is studying lower urinary tract (e.g., urinary bladder, urethra, prostate) pathologies and their treatment through novel drug design and development characterized using electrophysiological, molecular and optical approaches—resulting in several US patents. His lab was the first to demonstrate that the bladder urothelium is more than a barrier and produces nitric oxide in response to adrenergic agonists through direct microsensor measurements. There are three major projects funded through Dr. Kanai’s ongoing P01 and two R01’s grants: 1) The study of spinal cord injury and its consequences on lower urinary tract dysfunction; 2) Radiation-induced damage—mechanisms, prevention and treatment; and 3) The role of phosphodiesterase Type-5 (PDE5) inhibitors and soluble guanylate cyclase activators in treating bladder dysfunction.
Publications
For my complete bibliography, Click Here.
Sponsored Research/Activities
Title: PDE5 Inhibition of Afferents and Interstitial Cells in Overactive Mouse Bladders
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK098361
Start Year: 2014
End Year: 2019
Title: Effect of the Tachykinin NK2 Receptor Antagonist, Ibodutant on Proto-Oncogene Expression, After TNBS-Induced Colitis in Male and Female Guinea Pig
Role: Principal Investigator
Funding Agency: Menarini Ricerche S.p.A
Start Year: 2014
End Year: 2016
Title: Role of Nitric Oxide and Superoxide in Cystitis
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK071085
Start Year: 2013
End Year: 2018
Title: Mechanisms/Treatments of Lower Urinary Tract Dysfunction After Spinal Cord Injury
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: P01 DK093424
Start Year: 2013
End Year: 2018
Title: Effects of Solifenacin on Afferent Nerves and Interstitial Cells in the Overactive Bladder - Determined Using Optical Mapping
Role: Principal Investigator
Funding Agency: Astellas Pharma US
Start Year: 2012
End Year: 2014
Title: MOA of Mirabegron versus Solifenancin in Bladders of Normal Rats and Guinea Pigs
Role: Principal Investigator
Funding Agency: Astellas Pharma US
Start Year: 2012
End Year: 2014
Title: Use of Optical Mapping to Evaluate Mechanisms and New Therapies for Bladder Dysfunction Due to Spinal Cord Injury
Role: Principal Investigator
Funding Agency: Department of Defense
Start Year: 2011
End Year: 2014
Title: Critical Roles for Fibroblast Growth Factor Receptors in Bladder Development
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK104374
Start Year: 2015
End Year: 2020
Title: Effect of Aging on Urothelial Function
Role: Co-Investigator
Funding Agency: National Institute of Aging
Grant Number: R56 AG050408
Start Year: 2015
End Year: 2016
Title: Nitric Oxide in Bladder Neural-Epithelial Signaling
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R37 DK054824
Start Year: 2012
End Year: 2015
Notable Achievements
ASPET-Astellas Award in Translational Pharmacology, 2008