Department of Medicine

Department of Medicine

 Division of Renal-Electrolyte

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photo Edwin (Ed) K. Jackson, PhD

Professor of Pharmacology and Medicine

Associate Director, Center for Clinical Pharmacology


Phone: 412-648-1505

Office: Center for Clinical Pharmacology
100 Technology Drive, Suite 450
Pittsburgh, PA 15261
Phone: 412-648-1505
Fax: 412-648-1837
Education and Training
BS, University of Texas at Austin, College of Pharmacy, 1976
PhD, Pharmacology, University of Texas, 1979
Postdoctoral Fellowship in Clinical Pharmacology, Vanderbilt University, 1983
Research Interest
Dr. Ed Jackson is a senior experienced clinical pharmacologist in renal and cardiovascular pharmacology. He is Associate Director of the Center for Clinical Pharmacology and directs its laboratory resources in genetics, mass spectrometry, cell culture and animal physiology. His very highly active research program networks within the institution and between multiple institutions.
For my complete bibliography, Click Here.
Selected Publications:
Dubey, R.K., Fingerle, J., Gillespie, D.G., Mi,Z., Rosselli, M., Imthum, B., Jackson, E.K. Adenosine Attenuates Human Coronary Artery Smooth Muscle Cell Proliferation by Inhibiting Multiple Signaling Pathways That Converge on Cyclin D. Hypertension. 2015; 66(6): 1207-19.
Rigassi, L., Barchiesi Bozzolo, F., Lucchinetti, E., Zaugg, M., Fingerle, J., Rosselli, M., Imthum, B., Jackson, E.K., Dubey, R.K. 2-Methoxyestradiol blocks the RhoA/ROCK1 pathway in human aortic smooth muscle cells. American Journal of Physiology - Endocrinology and Metabolism. 2015; 309(12): E995-1007.
Jackson, E.K., Menshikova, E.V., Mi, Z., Verrier, J.D., Bansal, R., Janesko-Feldman, K., Jackson T.C., Kochanek, P.M. Renal 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase Is an Important Determinant of AKI Severity after Ischemia-Reperfusion. Journal of the American Society of Nephrology. 2016; 27(7): 2069-81.
Tofovic, S.P., Salah, E.M., Smits, G.J., Whalley, E.T., Ticho, B., Deykin, A., Jackson, E.K. Dual A1/A2B Receptor Blockade Improves Cardiac and Renal Outcomes in a Rat Model of Heart Failure with Preserved Ejection Fraction. Journal of Pharmacology and Experimental Therapeutics. 2016; 356(2): 333-40.
Jackson, E.K. Discovery and Roles of 2',3'-cAMP in Biological Systems. Handbook of Experimental Pharmacology. 2016.
Schaufelberger, S.A., Rosselli, M., Barchiesi, F., Gillespie, D.G., Jackson, E.K., Dubey, R.K. 2-Methoxyestradiol, an endogenous 17ß-estradiol metabolite, inhibits microglial proliferation and activation via an estrogen receptor-independent mechanism. American Journal of Physiology - Endocrinology and Metabolism. 2016; 310(5): E313-22.
Jackson, E.K., Boison, D., Schwarzchild, M.A., Kochanek, P.M. Purines: forgotten mediators in traumatic brain injury. Journal of Neurochemistry. 2016; 137(2): 142-53.
Schuler, P.J., Westerkamp, A.M., Kansy, B.A., Bruderek, K., Dissmann, P.A., Dumitru, C.A., Lang, S., Jackson, E.K., Brandau, S. Adenosine metabolism of human mesenchymal stromal cells isolated from patients with head and neck squamous cell carcinoma. Immunobiology. 2016.
Figueiro, F., Muller, L., Funk, S., Jackson, E.K., Battastini, A.M., Whiteside, T.L. Phenotypic and functional characteristics of CD39high human regulatory B cells (Breg). Oncoimmunology. 2016; 5(2): e1082703.
Tofovic, S.P., Jackson, E.K. Estrogens in Men: Another Layer of Complexity of Estradiol Metabolism in Pulmonary Hypertension. American Journal for Respiratory Critical Care. 2016; 193(10): 1087-90.