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Department of Medicine

Department of Medicine

 Division of Renal-Electrolyte

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photo Lori Birder, PhD

Professor of Medicine (Renal - Electrolyte Division)

Email: lbirder@pitt.edu

Phone: 412-383-7368

Contact
Office: 3550 Terrace Street
A1217 Scaife Hall
Pittsburgh, PA 15261
 
Phone: 412-383-7368
Fax: 412-383-7197
E-mail: lbirder@pitt.edu
Education and Training
Education
B.S. Chemistry, Duquesne University, Pittsburgh, PA., 1982
Ph.D. in Neuropharmacology, University of Pittsburgh, Pittsburgh, PA., 1992
NRSA Postdoctoral Fellow, University of North Carolina Chapel Hill
Research Interest
Dr. Birder’s laboratory is interested in understanding the complexities of urinary bladder epithelial (urothelial) cell function and urothelial cell-neuronal interactions. Dr. Birder’s investigations have revealed that the urothelium, a stratified epithelial layer that lines the bladder lumen, has the capacity to send signals to neighboring cells via the release of chemical mediators. This arrangement represents a departure from the conventional view of the urothelium as a simple barrier. She is addressing how pathology impacts mechanisms of urothelial communication, which may provide important insight into targets for new therapies for the clinical management of lower urinary tract disorders.
Publications
For my complete bibliography, Click Here.
Sponsored Research/Activities
Title: Effect of the Tachykinin NK2 Receptor Antagonist, Ibodutant on Proto-Oncogene Expression, After TNBS-Induced Colitis in Male and Female Guinea Pig
Role: Principal Investigator
Funding Agency: Menarini Ricerche S.p.A
Start Year: 2014
End Year: 2016
Title: The Role of Estrogen on Urothelial Structure and Signaling Functions as well as Bladder Afferent Activity
Role: Principal Investigator
Funding Agency: Astellas Pharma US
Start Year: 2013
End Year: 2016
Title: Nitric Oxide in Bladder Neural-Epithelial Signaling
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R37 DK054824
Start Year: 2012
End Year: 2017
Title: MOA of Mirabegron versus Solifenancin in Bladders of Normal Rats and Guinea Pigs
Role: Principal Investigator
Funding Agency: Astellas Pharma US
Start Year: 2012
End Year: 2014
Title: Use of Optical Mapping to Evaluate Mechanisms and New Therapies for Bladder Dysfunction Due to Spinal Cord Injury
Role: Principal Investigator
Funding Agency: Department of Defense
Start Year: 2011
End Year: 2014
Title: Role of Nitric Oxide in Interstitial Cystitis
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK057284
Start Year: 2010
End Year: 2016
Title: Effect of Aging on Urothelial Function
Role: Co-Principal Investigator
Funding Agency: National Institute of Aging
Grant Number: R56 AG050408
Start Year: 2015
End Year: 2016
Title: University of Pittsburgh O'Brien Cooperative Research Center Program-Project 1
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: U54 DK112079
Start Year: 2016
End Year: 2021
Title: PDE5 Inhibition of Afferents and Interstitial Cells in Overactive Mouse Bladders
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK098361
Start Year: 2014
End Year: 2019
Title: Roles of Nitric Oxide and Superoxide in Cystitis
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK071085
Start Year: 2013
End Year: 2018
Title: Biology and Function of the Bladder Umbrella Cell Paracellular Barrier
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK099196
Start Year: 2013
End Year: 2017
Title: Mechanisms/Treatments of Lower Urinary Tract Dysfunction After Spinal Cord Injury - Project 2
Role: Project Director
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: P01 DK093424
Start Year: 2013
End Year: 2018
Notable Achievements
APS Lazaro J Mandel Young Investigator Award in Epithelial Biology, 2003
MERIT Award NIH/NIDDK, 2007
Plenary Speaker GlaxoSmithKline Urology Therapy Area Review, 2007
External advisor for INComb and TRUST European Research Networks, 2010-13
Adjunct Professorship University of Antwerp (Belgium), 2013-14
Chair Basic Science Program-Society for Urology and Female Urodynamics (SUFU), 2013-17
Co-Chair Scientific Committee International Continence Society, 2016-18
Chair Neural Control Committee, 6th International Consultation on Incontinence, 2016
Co-Editor in Chief, Bladder Journal, 2014-present