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Department of Medicine

Department of Medicine

 Division of Renal-Electrolyte

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photo Catherine Baty, DVM, PhD

Research Assistant Professor, Renal Electrolyte Division

Email: cjb16@pitt.edu

Contact
Office: 3550 Terrace Street
Pittsburgh, 15261
 
E-mail: cjb16@pitt.edu
Education and Training
Education
DVM, College of Veterinary Medicine, University of Minnesota, 1998
PhD, North Caorlina State University, 1997
PhD Program, Small Animal Internal Medicine, North Carolina State University
Training
Internship, Small Animal Rotating, North Carolina State University, 1989
Post-doctoral fellow, University of Oxford, 1999
Post-doctoral fellow, Medical University of South Carolina, 2002
Research Interest
Dr. Baty’s research interests focus on the role of lymphatic vasculature in health and disease. She collaborated with geneticists Robert Ferrell and David Finegold to first identify connexin mutations as a cause of lymphedema in humans. She is using a high speed confocal imaging perfusion system for studies of renal lymphatics, ex vivo kidney slice cultures, perfused renal proximal tubules and renal blood flow imaging.
Clinical Interest
Dr. Baty is a Diplomate of the American College of Veterinary Internal Medicine, boarded in small animal internal medicine. Her veterinary clinical interests are mostly cardiovascular, especially the natural history and genetics of feline hypertrophic cardiomyopathy.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Navina, S., Acharya, C., DeLany, J.P., Orlichenko, L.S., Baty, C.J., Shiva, S.S., Durgampudi, C., Karlsson, J.M., Lee, K., Bae, K.T., Furlan, A., Behari, J., Liu, S., McHale, T., Nichols, L., Papachistou, G.I., Yadavm D., Singh, V.P. Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity. Science Translational Medicine. 2011; 3(107): 107ra110.
Sachdev, U., Cui, X., Hong, G., Namkoong, S., Karlsson, J.M., Baty, C.J., Tzeng, E. High mobility group box 1 promotes endothelial cell angiogenic behavior in vitro and improves muscle perfusion in vivo in response to ischemic injury. Journal of Vascular Surgery. 2012; 55(1): 180-91.
Montecalvo, A., Larregina, A.T., Shufesky, W.J., Stolz, D.B., Sullivan, M.L., Karlsson, J.M., Baty, C.J., Gibson, G.A., Erdos, G., Wang, Z., Milosevic, J., Tkacheva, O.A., Divito, S.J., Jordan, R., Lyons-Weiler,J., Watkins, S.C., Morelli, A.E. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood. 2012; 119(3): 756-66.
Finegold, D.N., Baty, C.J., Knickelbein, K.Z., Perschke, S., Noon, S.E., Campbell, D., Karlsson, J.M., Huang, D., Kimak, M.A., Lawrence, E.C., Feingold, E., Meriney, S.D., Brufsky, A.M, Ferrell, R.E. Connexin 47 mutations increase risk for secondary lymphedema following breast cancer treatment. Clinical cancer research:an official journal of the American Association for Cancer Research. 2012; 18(8): 2382-90.
Mishra, V., Cline, R., Noel, P., Karisson, J., Baty, C.J., Orlichenko, L., Patel, K., Trivedi, R.N., Husain, S.Z., Acharya, C., Durgampudi, C., Stolz, D.B., Navina, S., Singh, V.P. Src Dependent Pancreatic Acinar Injury Can Be Initiated Independent of an Increase in Cytosolic Calcium. PloS one. 2013; 8(6): e66471.
Kenche, H., Baty, C.J., Vedagirl, K., Shapiro, S.D., Blumental-Perry, A. Cigarette smoking affects oxidative protein folding in endoplasmic reticulum by modifying protein disulfide isomerase. FASEB journal: official publication of the Federation of American Societies for Experimental Biology. 2013; 27(3): 965-77.
Acharya, C., Cline, R.A., Jaligama, D., Noel, P., Delany, J.P., Bae, K., Furlan, A., Baty, C.J., Karlsson, J.M., Rasario, B.L., Patel K., Mishra, V., Bugampudi, C., Yadav, D., Navina, S., Singh, V.P. Fibrosis reduces severity of acute-on-chronic pancreatitis in humans. Gastroenterology. 2013; 145(2): 466-75.
Chu,C.T., Ji,J., Dagda, R.K., Jiang, J.F., Tyurina, Y.Y., Kapralov, A.A., Tyurin, V.A., Yanamala, N., Shrivastava, I.H., Mohammadyani, D., Qiang Wang, K.Z., Zhu, J., Klein-Seetharaman, J., Balasubramanian, K., Amoscato, A.A., Borisenko, G., Huang, Z., Gusdon, A.M., Cheikhi, A., Baty, C. Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. Nature Cell Biology. 2013; 15(10): 1197-205.
Raghavan, V., Rbaibi, Y., Baty, C.J., Weisz, O.A. Rab11a-positive compartments in proximal tubule cells sort fluid-phase and membrane cargo. Cell Physiology. 2014; 306(5): C441-9.
Saurabh, S., Beck, L.E., Maji, S., Baty, C.J., Wang, Y., Yan, Q, Watkins, S.C, Bruchez, M.P. Multiplexed modular genetic targeting of quantum dots. ACS nano. 2014; 8(11): 11138-46.
Sponsored Research/Activities
Title: Genetics of Extracellular Matrix in Health and Disease
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL090648
Start Year: 2015
End Year: 2019
Title: Interventions to Reduce Hypercoagulability in Old SIV-Infected NHPs
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL123096
Start Year: 2015
End Year: 2020
Title: Pittsburgh Center for Kidney Research - Straub Pilot
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: P30 DK079307
Start Year: 2015
End Year: 2017
Title: Regulation of Th17 Functions in Autoimmune CNS Inflammation
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R01 AI110822
Start Year: 2014
End Year: 2019
Title: Flow-Stimulated Endocytosis in the Proximal Tubule
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK101484
Start Year: 2014
End Year: 2018
Title: Micro-Scale Analysis of Mesenchymal to Epithelial Transition in Lung Cancer
Role: Co-Investigator
Funding Agency: National Cancer Institute
Grant Number: R21 CA191647
Start Year: 2014
End Year: 2016
Title: SIV Pathogenesis in African Monkeys and Pigtailed Macaques
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL117715
Start Year: 2014
End Year: 2016
Title: Pittsburgh Center for Kidney Research - Core C
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: P30 DK079307
Start Year: 2013
End Year: 2018
Title: Apical Protein Sorting in Renal Epithelial Cells
Role: Collaborator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK100357
Start Year: 2014
End Year: 2018
Title: IL-23/STAT3-Driven Oral Immune Responses to Candida Albicans
Role: Microscopist
Funding Agency: National Institute of Dental/Craniofacial Research
Grant Number: R01 DE023815
Start Year: 2016
End Year: 2016