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Department of Medicine

Department of Medicine

 Division of Renal-Electrolyte

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photo Gerard Apodaca, PhD

Professor of Cell Biology & Physiology

Email: gla6@pitt.edu

Phone: 412-383-8893

Contact
Office: 980 Scaife Hall
3550 Terrace St.
Pittsburgh, PA 15261
 
Phone: 412-383-8893
Fax: 412-383-8955
E-mail: gla6@pitt.edu
Administrative Assistant:
Jennifer Bruns
Address: S974 Scaife Hall
Pittsburgh, PA 15216
Phone: 412-383-9753
Education and Training
Education
B.A. in Biology, Rollins College, Winter Park, FL., 1983
Ph.D. in Experimental Pathology, University of California, San Francisco, CA, 1989
Training
Postdoctoral Fellow, University of California, San Francisco, CA., 1995
Research Interest
Dr. Apodaca’s lab studies the biology of the epithelial cells that line the inner surface of the bladder and ureters (urothelium), as well the cells that line the tubules that comprise the kidney nephron. Dr. Apodaca’s lab has three major projects in the laboratory: 1) Studies of stretch-regulated membrane traffic in umbrella cells. 2) Analysis of tight junction morphology and function in response to stretch. 3) Exploration of what the role is of uroplakins in urinary tract development and congenital anaomalies of the kidney and urinary tract.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Gallo LI, Liao Y, Ruiz WG, Clayton DR, Li M, Liu YJ, Jiang Y, Fukuda M, Apodaca G, Yin XM. TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells. Molecular Biology of the Cell. 2014; 25(23): 3779-97.
Sponsored Research/Activities
Title: Role of Uroplakins in Urinary Tract Development and CAKUT
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK104287
Start Year: 2014
End Year: 2019
Title: Biology and Function of the Bladder Umbrella Cell Paracellular Barrier
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK099196
Start Year: 2013
End Year: 2017
Title: Endocytic and Exocytic Traffic in Bladder Uroepithelium
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R37 DK054425
Start Year: 2009
End Year: 2015
Title: Effect of Aging on Urothelial Function
Role: Co-Principal Investigator
Funding Agency: National Institute of Aging
Grant Number: R56 AG050408
Start Year: 2015
End Year: 2016
Title: Mechanisms/Treatments of Lower Urinary Tract Dysfunction After Spinal Cord Injury - Project 2
Role: Co-Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: P01 DK093424
Start Year: 2013
End Year: 2018
Title: Flow-Stimulated Endocytosis in the Proximal Tubule
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK101484
Start Year: 2014
End Year: 2018
Title: Nitric Oxide in Bladder Neural-Epithelial Signaling
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R37 DK054824
Start Year: 2012
End Year: 2017
Title: Pittsburgh Center for Kidney Research - Core C
Role: Program Director
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: P30 DK079307
Start Year: 2013
End Year: 2018
Notable Achievements
Established Investigator Award, AHA, 2003
MERIT Award, NIH, 2004
Member ACS Cell Structure and Metastasis Study Section, 2005
Appointed UPSOM Academy of Master Educators, 2006
William E. Brown MSTP Mentor of the Year Award, 2007
Member NIH Membrane Biology and Protein Processing Study Section, 2012
Associate Editor, American Journal of Physiology, Renal Physiology, 2007
Editor, Section in Membrane Traffic, Frontiers in Cell and Developmental Biology, 2013
American Society of Cell Biology, 1993
American Physiological Society, 2002