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Department of Medicine

Department of Medicine

  PhD Community

PhD Community Member



Members:

Mandy J. McGeachy, PhD

Assistant Professor, Rheumatology
3500 Terrace Street
BST South, S719
Pittsburgh, PA 15261

Email: mmcgeach@pitt.edu



Conceptual Schematic

THE THREE MOST SIGNIFICANT QUESTIONS THAT DEFINE YOUR RESEARCH PROGRAM:
How is Th17 cell development regulated?

What factors drive Th17 cells' pathogenic functions in vivo?

How does blockade of specific immune pathways impact inflammatory T cells in humans with autoimmune disease?

FIVE KEYWORDS THAT DESCRIBE YOUR AREAS OF INTEREST:
Th17 cells, autoimmunity, immunoregulation, cytokines, inflammation

TECHNIQUES, MODELS, METHODS, ANALYTIC APPROACHES, ETC:

Experimental autoimmune encephalomyelitis (model of autoimmune CNS inflammation in multiple sclerosis)

Isolation of live immune cells from mouse lymph node, CNS and gut, human inflamed synovial tissue and blood

In vitro T cell differentiation cultures and functional assays (mouse and human)

Citrobacter rodentium gut inflammatory model

Flow cytometry (including cell sorting for low-yield RNA-Seq)