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Department of Medicine

Department of Medicine

  PhD Community

PhD Community Member



Members:

Bill Chen, PhD

Associate Professor, PACCM
UPMC Montefiore Hospital - NW628
3459 Fifth Avenue
Pittsburgh, PA 15213

Email: bec31@pitt.edu



Conceptual Schematic

THE THREE MOST SIGNIFICANT QUESTIONS THAT DEFINE YOUR RESEARCH PROGRAM:
Can we identify novel pathways that regulate cell proliferation, cell cycle, mitosis and inflammation?
Can we identify the roles of ubiquitin E3 ligases in these novel pathways?
Can we screen and design novel small molecules that targets and block these ubiquitin E3 ligases.

FIVE KEYWORDS THAT DESCRIBE YOUR AREAS OF INTEREST:
Cell cycle, mitosis and cancer;
Innate immunity and inflammation;
TGF pathway and fibrosis;
In silico small molecule screening
Drug discovery and development

TECHNIQUES, MODELS, METHODS, ANALYTIC APPROACHES, ETC:

Ubiquitin E3 ligase screening and functional study
Various inflammatory in vitro and in vivo models
Protein modeling, in silico drug screening and synthesis
PDPK models, ADME and animal testing.