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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Jonathan K. Alder, PhD

Assistant Professor of Medicine

Email: jalder@pitt.edu

Phone: 412-692-2118

Contact
Office: UPMC Montefiore, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-692-2118
Fax: 412-692-2260
E-mail: jalder@pitt.edu
Administrative Assistant:
Patty Geraci
Email: geracip@upmc.edu
Phone: 412-692-2118
Fax: 412-692-2260
Research Interest
My research focuses on understanding the role of telomere length in human health and disease. Telomeres are caps on the ends of each of chromosomes and shorten as we age. My current interest is exploring the mechanisms by which telomere dysfunction causes age-related lung diseases including pulmonary fibrosis and emphysema. Our lab uses a number of approaches to explore that pathogenesis of short-telomere mediated disease including genetics, cell biology, and animal models. We hope these studies will lead to a deeper understanding of how telomere dysfunction contributes to lung disease and potentially inform rational therapies.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Stanley, SE, Gable, DL, Wagner, CL, Carlile, TM, Hanumanthu, VS, Podlevsky, JD, Khalil, SE, DeZern, AE, Rojas-Duran, MF, Applegate, CD, et al. Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis-emphysema. Sci Transl Med. 2016; Aug 10;8: (351).
Alder, JK, Stanley, SE, Wagner, CL, Hamilton, M, Hanumanthu, VS, Armanios, M. Exome sequencing identifies mutant TINF2 in a family with pulmonary fibrosis. CHEST. 2015; May;147(5): 1361-1368.
Alder, JK, Chen, JJ, Lancaster, L, Danoff, S, Su, SC, Cogan, JD, Vulto, I, Xie, M, Qi, X, Tuder, RM, Phillips, JA 3rd, Lansdorp, PM, Loyd, JE, Armanios, MY. Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proc Natl Acad Sci U S A. 2008; Sep 2;105(35): 13051-6.
Alder, JK, Guo, N, Kembou, F, Parry, EM, Anderson, CJ, Gorgy, AI, Walsh, MF, Sussan, T, Biswal, S, Mitzner, W, Tuder, RM, Armanios, M. Telomere length is a determinant of emphysema susceptibility. Am J Respir Crit Care Med. 2011; Oct 15:184(8): 904-12.
Alder, JK, Parry, EM, Yegnasubramanian, S, Wagner, CL, Lieblich, LM, Auerbach, R, Auerbach, AD, Wheelan, SJ, Armanios, M. Telomere phenotypes in females with heterozygous mutations in the dyskeratosis congenita 1 (DKC1) gene. Hum Mutat. 2013; Nov;34(11): 1481-5.
Alder, JK, Barkauskas, CE, Limjunyawong, N, Stanley, SE, Kembou, F, Tuder, RM, Hogan, BL, Mitzner, W, Armanios, M. Telomere dysfunction causes alveolar stem cell failure. Proc Natl Acad Sci U S A. 2015; Apr 21;112(16): 5099-104.
Sponsored Research/Activities
Title: Telomeres and Telomerase in Cancer
Role: Co-Investigator
Funding Agency: Johns Hopkins University
Grant Number: R35 CA209974
Start Year: 2017
End Year: 2017
Notable Achievements
Parker B. Francis Fellow, 2010