Department of Medicine

University of Pittsburgh

Division of Pulmonary, Allergy, and Critical Care Medicine
3459 Fifth Avenue,
628 NW
Pittsburgh, PA 15213
Academic Office: (412) 692-2210
Comprehensive Lung Center (Patient Care and Referral): (412) 648-6161

Andrej Aleksandar Petrov, MD

Assistant Professor of Medicine
UPMC Montefiore Hospital - NW628
3459 Fifth Avenue
Pittsburgh, PA 15213

Phone: 412-864-3199
Fax: 412-692-2260
Email: petrovaa@upmc.edu
Assistant: Judy Nauman
Assistant Email: naumanja@upmc.edu

Bio

Andrej Petrov graduated cum laude from the University Of Belgrade School of Medicine in Belgrade, Serbia. He completed residency in Internal Medicine at Harrisburg Hospital, Pennsylvania and fellowship in Allergy and Clinical Immunology at the University of Pittsburgh Medical Center (UPMC). He has served as a Medical Director of Allergy and Clinical Immunology at UPMC Presbyterian/Montefiore since 2007. Additionally, he became a chief of Allergy at UPMC Shadyside in 2012. He serves as an associate fellowship program director in allergy and immunology and supervises training of allergy and pulmonary fellows in adult allergy and clinical immunology. Dr. Andrej Petrov is board certified in Allergy and Clinical Immunology and Internal Medicine.

Dr. Petrov is reviewing a chest CT with allergy-immunology fellows.

Dr. Petrov is discussing indications for flexible nasal endoscopy and laryngoscopy with allergy-immunology fellows.

Clinical Interests

During his tenure, Dr. Petrov has worked to establish and grow the allergy, asthma and immunology outpatient and inpatient clinical programs. This effort has led to remarkable growth of the outpatient allergy, asthma and immunology clinic in the Comprehensive Lung Center with a focus on difficult to manage clinical conditions including co-existent upper and lower airway diseases (chronic sinusitis and bronchiectasis in immunodeficiency patients, Samter’s triad [ nasal polyps, asthma and aspirin allergy], evaluation of multifactorial causes of chronic cough, and conditions that mimic or complicate asthma such as vocal cord dysfunction), adult immunodeficiency (including acquired immunodeficiency secondary to immunosuppressive medications), urticaria (hives) and angioedema (swelling), anaphylaxis and systemic mastocytosis, food allergy, and atopic and contact dermatitis. Dr. Petrov has implemented outpatient rapid desensitization protocols for patients with allergic rhinitis (environmental allergies) and bee sting allergy. He has introduced novel outpatient drug desensitization protocols in patients with drug allergies. Additionally, Dr. Petrov has established inpatient drug desensitization protocols for antibiotics, monoclonal antibodies, aspirin and other medications.

Academic and Research Interests

Dr. Petrov’s research interests focus on conditions that mimic asthma, hypogammaglobulinemia in lung transplant patients, and allergic drug reactions.

Vocal Cord Dysfunction (VCD) is often misdiagnosed and mistreated as asthma, leading to increased asthma medication use and healthcare utilization. While laryngoscopy remains the gold standard for VCD diagnosis, it is often not readily available or practiced by many physicians who may encounter this disorder. Additionally, laryngoscopy may be normal if performed when a patient is asymptomatic.
Dr. Petrov and co-inventers developed the Pittsburgh VCD Index, a simple, valid and easy to use tool for diagnosing VCD. This novel scoring system identified features of VCD that distinguish it from asthma. Symptoms of throat tightness and dysphonia, absence of wheezing, and the presence of odors as a symptom trigger were found to be key features of vocal cord dysfunction that distinguish it from asthma.  Using the appropriate cut-off, the index had a sensitivity and specificity of 83% and 95% respectively, and its utility was confirmed in a population of patients with laryngoscopy-proven VCD. Pittsburgh VCD Index may decrease health care costs, unnecessary medication use and healthcare utilization by making a timely diagnosis of VCD in a patient mistreated for asthma.

Key Publications:

Traister RS, Fajt ML, Landsittel D, Petrov A. A Novel Scoring System to Distinguish Vocal Cord Dysfunction from Asthma. Journal of Allergy and Clinical Immunology-In Practice. 2014;2:65-69

Traister RS, Fajt ML, Whitman-Purves E, Anderson WC, Petrov AA. A retrospective analysis comparing subjects with isolated and coexistent vocal cord dysfunction and asthma. Allergy Asthma Proc. 2013 Jul;34(4):349-55

T. Shankar, J. Gribowicz, M. Crespo, F.P. Silveira, J. Pilewski, A.A. Petrov Subcutaneous IgG replacement therapy is safe and well tolerated in lung transplant recipients. International Immunopharmacology

Shankar T, Petrov AA. Omalizumab and hypersensitivity reactions. Curr Opin Allergy Clin Immunol. 2013 Feb; 13(1):19-24.

Bray S, Fajt M, Petrov A.  Successful Treatment of Exercise Induced Anaphylaxis with Omalizumab, Annals of Allergy, Asthma & Immunology Volume 109, Issue 4, 2012

Corcoran TE, Venkataramanan R, Hoffman RM, George MP, Petrov A, Richards T, Zhang S, Choi J, Gao YY, Oakum CD, Cook RO, Donahoe M. Systemic Delivery of Atropine Sulfate by the MicroDose Dry-Powder Inhaler J Aerosol Med Pulm Drug Deliv. 2012 Jun 12

Owens G, Petrov A. Successful desensitization of three patients with hypersensitivity reactions to omalizumab. Curr Drug Saf. 2011 Nov 1;6(5):339-42.

Shayna Burke, Andrej Petrov, Jonas Johnson, Andrew MacGinnitie Successful use of ecallantide to treat a hereditary angioedema attack after failure of C1 inhibitor prophylaxis, Annals of Allergy, Asthma & Immunology Volume 107, Issue 2, August 2011

Fajt M, Petrov A   Outpatient Aspirin Desensitization for Patient with Aspirin Hypersensitivity and Cardiac Disease;  Crit Pathways in Cardiol 2011;10: 17–21

Fajt M,  Petrov A. Clopidogrel Hypersensitivity: A Novel Multi-Day Outpatient Oral Desensitization Regimen; The  Annals of Pharmacotherapy  January 2010, Volume 44

PubMed Link