Department of Medicine
University of Pittsburgh
Thottala Jayaraman, PhD
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Research Assistant Professor 10051-2B BST 3, Phone: 412-624-0465 |
Bio
Thottala Jayaraman received his PhD in immunology from the All India Institute of Medical Sciences in 1989. After completing his post-doctoral fellowships at Yale University and Mount Sinai Medical Center, he joined Columbia University faculty as an Assistant Professor in the Department of Medicine in 1998. In addition, he also held joint appointments as an Associate Director of Vascular Biology Research Program and an Assistant Professor of Neurosurgery at St. Luke’s Roosevelt Hospital Center in New York before joining the University of Pittsburgh.
Research Interests
Dr. Jayaraman's research interests are centered on calcium signaling, cell cycle, pro- and anti-apoptotic pathways, inflammation, and vascular biology research.
Since 1992, Dr. Jayaraman’s research has made several important contributions that include the demonstration of FKBP interaction with RyR, utility of rapamycin in limiting restenosis, a role for IP3R-mediated calcium release in activation induced cell death, involvement of TNFa-mediated inflammation in cerebral aneurysm development, direct activation of IP3-gated calcium signaling during cell cycle progression.
Dr. Jayaraman’s current research is focused on neuroglobin to: 1) investigate its role in limiting cellular damage by hypoxia; 2) examine its structural features that regulate expression and ligand binding; and 3) characterize its nitrite reductase activity. He plans to develop unique reagents, including mutants and a panel of neuroglobin specific phospho-antibodies, designed to investigate its function at a molecular level.
Key Publications
Jayaraman T, Paget A, Shin YS, Niimi Y, Chaudhry H, Silane M and Berenstein (2008). TNFa mediated inflammation in cerebral aneurysms: A potential link to growth and rupture. Vascular Health Management (in press)
Malathi K, Li X, Krizanova O, Ondrias K, Sperber K, Ablamunits V and Jayaraman T (2005). Cdc2/Cyclin B1 interacts with and modulates IP3 receptor (type 1) functions. Journal of Immunology 175:6205-6210
Jayaraman T, Berenstein V, Li X, Mayer J, Silane M, Shin YS, Niimi Y, Kilic T, Gunel M, Berenstein A (2005). Tumor necrosis factor alpha is a key modulator of inflammation in cerebral aneurysm. Neurosurgery 57:558-64.
Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR (2000). PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 101: 365-76.
Jayaraman T, Marks AR (2000). Calcineurin is downstream of the inositol 1,4,5-trisphosphate receptor in the apoptotic and cell growth pathways. Journal of Biological Chemistry 275: 6417-20
Jayaraman T, Marks AR (1997). T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis. Molecular Cellular Biology 17: 3005-12.
Jayaraman T, Ondrias K, Ondriasova E, Marks AR (1996). Regulation of the inositol 1,4,5-trisphosphate receptor by tyrosine phosphorylation. Science 272: 1492-94.
Marx SO, Jayaraman T, Go LO, Marks AR (1995). Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells. Circulation Research 76: 412-17.
Jayaraman T, Brillantes AM, Timerman AP, Fleischer S, Bromage HE, Tempst P, Marks AR (1992). FK506 binding protein associated with the calcium release channel (ryanodine receptor). Journal of Biological Chemistry 267: 9474-9477.