PACCM and Hematology/Oncology faculty collaborate to identify link between telomere mutations and melonama
In a recent Science paper, Drs. Jonathan Alder, John Kirkwood and others describe TPP1 mutations leading to telomere lengthening and the promotion of melanoma cells.
Led by Drs. Toren Finkel and Melanie Königshoff, the TriState SenNet TMC combines the expertise of faculty from Pitt, CMU, OSU, and URMC to develop a high-resolution map of the senescent cell population in the human lung and heart, define the physiological drivers of senescence, and provide a rational approach to understand the therapeutic potential of senolytic therapy.
To better understand potential damage that emerging vaping products may have on human lungs, Dr. Benam and his team have created a first-in-kind biologically inspired robotic system that quantitatively analyzes submicron and microparticles generated from electronic cigarettes in real-time while mimicking clinically relevant breathing and vaping topography exactly as happens in humans.
In a recent Nature Communications article, the Chen lab discuss how a high-throughput screen could be used to identify FDA-approved compounds that may resist SARS-CoV-2 infection.