Department of Medicine
Faculty Profiles by Division

Division of Infectious Diseases

Faculty Profiles
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photo Cornelius (Neil) J. Clancy, MD

Infectious Diseases

Associate Chief of VA Pittsburgh Health System (VAPHS) and Opportunistic Pathogens

Associate Professor of Medicine

Director, Mycology Program

Chief, Infectious Diseases Section, VA Pittsburgh Health Care System

Email: cjc76@pitt.edu

Phone: 412-647-0996
Contact
Office: BST E1054
200 Lothrop Street
Pittsburgh, PA 15213
 
Phone: 412-647-0996
Fax: 412-648-8455
E-mail: cjc76@pitt.edu
Administrative Assistant:
Megan Moore
Email: MFM62@pitt.edu
Phone: 412-624-9583
Education and Training
Education
B.A, Natural Sciences, The Johns Hopkins University, Baltimore, MD, 1984
M.D., Washington University School of Medicine, 1991
Training
Residency, Internal Medicine, The Union Memorial Hospital, Baltimore MD, 1994
Chief Resident, Internal Medicine, The Union Memorial Hospital, Baltimore, MD, 1995
Fellowship, Infectious Diseases, University of Florida, 2000
Research Interest
Dr. Clancy's laboratories are interested in the molecular pathogenesis of invasive infections caused by the fungus Candida albicans.

Dr. Clancy's labs have implicated several novel genes in both organisms that contribute to the pathogenesis of candidiasis and aspergillosis. Biological processes related to these genes that are studied in the lab include histone methylation and transcriptional regulation, DNA damage responses, and phosphoinositide regulation.

In addition, he and Dr. Nguyen collaborate on research about mechanisms of antimicrobial resistance in bacteria and fungi and their clinical relevance.
Publications
Selected Publications:
Raman, SB, Nguyen, MH, Cheng, S, Badrane, H, Iczkowski, KA, Wegener, M, Gaffen, SL, Mitchell, AP, Clancy, CJ. A competitive infection model of hematogenously disseminated candidiasis in mice redefines the role of Candida albicans IRS4 in pathogenesis. Infection and Immunity. 2013; 81(5): 1430-8.
Badrane, H, Nguyen, MH, Clancy, CJ. Highly Dynamic and Specific Phosphatidylinositol 4,5-Bisphosphate, Septin, and Cell Wall Integrity Pathway Responses Correlate with Caspofungin Activity against Candida albicans. Antimicrobial Agents and Chemotherapy. 2016; 60(6): 3591-600.
Shields, RK, Nguyen, MH, Press, EG, Cumbie, R, Driscoll, E, Pasculle, AW, Clancy, CJ. Rate of FKS Mutations among Consecutive Candida Isolates Causing Bloodstream Infection. Antimicrobial Agents and Chemootherapy. 2015; 59(12): 7465-70.
Clancy, CJ, Meslin, C, Badrane, H, Cheng, S, Losada, LC,, Nieman, WC, Vergidis, P, Clark, NL, Nguyen, MH. Candida albicans Transcriptional Profiling Within Biliary Fluid From a Patient With Cholangitis, Before and After Antifungal Treatment and Surgical Drainage Open Forum. Infectious Diseases. 2016; 3(3): doi:10.1093/ofid/ofw120.
Shankar, J, Nguyen, MH, Crespo, MM, Kwak, EJ, Lucas, SK, McHugh, KH, Mounaud, S, Alcorn, JF, Pilewski, JM, Shigemura, N, Kolls, JK, Nieman, WC, Clancy, CJ. Looking Beyond Respiratory Cultures: Microbiome-Cytokine Signatures of Bacterial Pneumonia and Tracheobronchitis in Lung Transplant Recipients. American Journal of Transplantation. 2016; 16(6): 1766-78.
Sponsored Research/Activities
Title: Polyclonality of carbapenem resistant Enterobacteriaceae bloodstream infections
Role: Principal Investigator
Funding Agency: National Institute of Health
Grant Number: R21 AI152018
Start Year: 2020
End Year: 2022
Title: Timely and active antibiotic therapy against Pseudomonas aeruginosa among patients with chronic structural lung disease
Role: Principal Investigator
Funding Agency: Merck
Grant Number: RES 59856
Start Year: 2020
End Year: 2022
Title: Candida albicans regulatory pathways contributing to intra-abdominal candidiasis
Role: Principal Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R21 AI144390
Start Year: 2019
End Year: 2021
Title: Impact of Protocol-Driven T2Ba Bacteria Testing on Antimicrobial usage and Outcomes of Liver and Kidney Transplant Recipients
Role: Principal Investigator
Funding Agency: T2 Biosystems
Start Year: 2019
End Year: 2020
Title: Mechanisms of ceftazidime-avibactam susceptibility and resistance among Enterobacteriaceae expressing variant KPCs
Role: Principal Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R21 AI142049
Start Year: 2018
End Year: 2020

Division Websites

Cardiology

Endocrinology and Metabolism

Gastroenterology, Hepatology and Nutrition

General Internal Medicine

Geriatric Medicine
Hematology/Oncology

Infectious Diseases

Pulmonary, Allergy and Critical Care Medicine

Renal-Electrolyte

Rheumatology and Clinical Immunology

Contact

Department of Medicine
1218 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Email:  chairoff@pitt.edu
Phone:  412-648-9636
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