Department of Medicine

University of Pittsburgh

Edward Chu, MD


Professor of Medicine

Professor of Pharmacology&Chemical Biology

Chief, Division of Hematology-Oncology

Deputy Director, University of Pittsburgh Cancer Institute

Associate Director, Drug Discovery Institute

Office: 5150 Centre Avenue
Fifth Floor, Room 571
Pittsburgh, PA 15232
Phone: 412-648-6589
Fax: 412-648-6579

B.S., Brown University, 1980
M.M.S., Brown University, 1983
M.D., Brown University, 1983

Internship in Internal Medicine, Brown University, 1983
Residency in Internal Medicine, Brown University, 1984
Residency in Internal Medicine, Brown University, 1985
Chief Resident in Internal Medicine, Brown University, 1986
Medical Oncology Fellowship, National Cancer Institute, 1989

Area of Specialization/Research Interest  
Cancer pharmacology
Cancer drug development
Phase I/II clinical trials
Drug resistance
Regulation of gene expression
Translational regulation
Chinese herbal medicine
Colorectal cancer
GI cancers

Dr. Edward Chu is involved in basic, clinical, and translational cancer research. His basic research interests have focused on characterization of the molecular mechanisms underlying the development of cellular drug resistance, especially as it relates to the fluoropyrimidine class of anticancer agents. His research group was the first to identify translational autoregulation as a novel regulatory mechanism in eukaryotes for controlling the expression of the folate-dependent enzymes, thymidylate synthase and dihydrofolate reductase. His clinical translational research efforts have focused on identifying novel drugs and treatment strategies for colorectal cancer and other GI cancers and in developing early-phase I/II clinical trials. He has a strong interest in integrating Chinese herbal medicine with standard cancer chemotherapy with the goal of enhancing clinical activity and reducing the toxicity associated with chemotherapy.