Department of Medicine

University of Pittsburgh

Lisa H. Butterfield, PhD


Professor of Medicine, Surgery and Immunology

Director, UPCI Immunologic Monitoring and Cellular Products Laboratory

Office: Hillman Cancer Center, Research Pavilion 1.27
5117 Centre Ave
Pittsburgh, PA 15213
Phone: 412-623-1418
Fax: 412-624-0264

B.S., Biology, Rensselaer Polytechnic Institute, 1986
Ph.D., Biology, University of California Los Angeles, 1993

Postdoctoral Fellowship, University of California Los Angeles, 1995
Postdoctoral Fellowship, University of California Los Angeles, 1998

Area of Specialization/Research Interest  
Tumor Immunology
Hepatocellular Cancer
Dendritic Cells
Tumor Antigens

The Butterfield laboratory studies the interaction between the immune system and cancer. We are primarily interested in melanoma and hepatocellular cancer. In melanoma, the more immunogenic nature of the tumor and the depth to which it has been studied by many groups has created a level of understanding of the molecular changes in the tumor and the variety of the immunological responses occurring in patients which allows for highly detailed study of these responses as well as design of complex immunotherapy clinical trials to induce more potent anti-tumor responses. In hepatocellular cancer, the lack of spontaneous immunity and paucity of known tumor antigens creates an opportunity for study of new immunotherapy for this difficult disease.

Lab Personnel and Web page
View Lab Webpage
Research Link
View Research Webpage

Recent Grants
Title: “Multiple Tumor Antigen-loaded DC Vaccine for Hepatocellular Cancer”
Role: PI
Amount: $1,300,000 total
Funding Agency: NCI
Start Year: 2010
End Year: 2015
Title: Multiple Antigen-Engineered DC Immunization and IFNa Boost for Metastatic Melanoma
Role: PI Skin SPORE Project 2, SPORE PI: J. M. Kirkwood PI Core B IMCPL
Amount: $140,000/year
Funding Agency: NCI
Start Year: 2008
End Year: 2018

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