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The Zhang lab develops the most advanced mouse models for lung cancer immunotherapy. The main research focuses of the Zhang’s lab are:
1. establishing new immunocompetent mouse models for lung cancer and utilizing them to study the therapeutic efficacy and mechanisms of novel combination of targeted therapy with immunotherapy
2. identifying new therapeutic vulnerabilities to overcome drug resistance in lung cancer
3. characterizing the organ-specific tumor immune contexture to develop immunotherapeutic strategies
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