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Department of Medicine

Department of Medicine

  Division of Hematology/Oncology

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photo Quanhong Sun, PhD

Research Instructor, Department of Medicine

Email: sunq2@upmc.edu

Phone: 412-623-7735

Contact
Office: Hillman Cancer Center lab1.20
5117 Centre Ave
Pittsburgh, PA 15213
 
Phone: 412-623-7735
Fax: 412-623-1415
E-mail: sunq2@upmc.edu
Education and Training
Education
PhD, Chinese Academy of Sciences, 2005
Training
Postdoctoral Associate, University of Pittsburgh, 2009
Research Interest
Determining the mechanism by which Measles virus nucleocapsid protein (MVNP) results in aberrant osteoclast differentiation. MVNP has been shown to be able to induce a Pagetic phenotype when transduced into osteoclast precursors and there is increasing evidence that it can play a role in the development of Paget’s disease. We have reported that MVNP signals through the IKK family member TBK1 to increase IL-6, a key player in creating the pagetic microenvironment. Current studies seek to determine the mechanism by which MVNP regulates the competitive balance between TBK1 activity and levels of OPTN (a negative regulator) in osteoclasts. We are also using transgenic mouse models to determine whether increased TBK1 expression in OCL precursors will phenocopy MVNP or cooperate with p62P394L to generate the pagetic phenotype in mice. Further, we are testing whether TBK1 is required for the formation of pagetic lesions in vivo by crossing TBK1 conditional knockout mice with MVNP/P62KI mice. 2) Determing the role and mechanisms of TBK1 and its homolog IKK? in other inflammatory bone diseases, such as multiple myeloma (MM) bone disease. To address this point, we seek to determine the requirement for TBK1 and/or IKK? activity in myeloma cells, osteoclasts, and osteoblast precursor interactions in the MM bone microenvironment. Further, we are working to determine if targeting TBK1/IKK? signaling in vivo will decrease MMBD in an immunocompetent MM mouse model.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Sun Q, Sammut B, Wang F, Kurihara N, Windle J, Roodman GD, Glason DL. TANK Binding Kinase 1 (TBK1) Mediates MVNP Effects in Pagetic Osteoclasts. Journal of Bone and Mineral Research. 2014; 29(1): 90-102.
Sun J, Sun Q, Brown M, Dudgeon C, Chandler J, Shu Y, Xu X, Zhan L, Yu J. The multiple-targeted kinase inhibitor Sunitinib induces apoptosis in colon cancer cells via PUMA. PLoS One. 2012; 7(3): e43158.
D'Souza S, Prete D, Jin S, Sun Q, Huston AJ, Kostov FE, Sammut B, Hong CS, Anderson JL, Patrene KD, Yu S, Velu CS, Xiao G, Leighton H, Roodman GD, Galson DL. Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease. Blood. 2011; 118(26): 6871-80.
Hua L, Wang P, Sun Q, Ding WX, Yin XM, Sobol RW, Stolz DB, Yu J, Zhang L. Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1. Cancer Research. 2011; 71(1): 3625-34.
Sun Q, Zheng X, Zhang L, Yu J. Smac Modulates Chemosensitivity in Head and Neck Cancer Cells through the Mitochondrial Apoptotic Pathway. Clinical Cancer Research. 2011; 17(8): 2361-72.
Dudgeon C, Wang P, Sun X, Peng R, Sun Q, Yu J, Zhang L. PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01. Molecular Cancer Therapeutics. 2010; 9(11): 2893-902.
Yue W, Sun Q, Landreneau R, Wu C, Siegfried JM, Yu J, Zhang L. Fibulin-5 suppresses lung cancer invasion by inhibiting MMP-7 expression. Cancer Research. 2009; 69(15): 6331-6338.
Sun Q, Ming L, Thomas S, Wang Y, Chen ZG, Ferris R, Grandis J, Zhang L, Yu J. PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells. Oncogene. 2009; 28(24): 2348-57.
Yue W, Sun Q, Dacic S, Landreneau RJ, Siegfried JM, Yu J, Zhang L. Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer. Carcinogenesis. 2008; 29(1): 84-92.
Sun Q, Sakaida T, Yue W, Gollin S, Yu J. Chemosensitization of head and neck cancer cells by PUMA. Molecular Cancer Therapeutics. 2007; 6(12): 3180-8.
Notable Achievements
Science and Technology Award, Shanxi Province, People's Republic of China, 20014
Poster Presentation award, 18th annual University of PIttsburgh Cancer Institute Retreat, 2006
Basic research, 2nd place University of PIttsburgh Department of Pathology Research Day, 2009
Plenary Poster Award, American Society for Bone and Mineral Research, 2011
Concurrent Oral, American Society for Bone and Mineral Research, 2012/2014
Plenary Poster Award, American Society for Bone and Minteral Research, 2015