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Department of Medicine

Department of Medicine

  Division of Hematology/Oncology

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photo Malabika Sen, PhD

Research Assistant Professor

Email: senm@upmc.edu

Phone: 412-623-7821

Contact
Office: 2.7, Hillman Cancer Center
5115 Centre Avenue
Pittsburgh, PA 15232
 
Phone: 412-623-7821
Fax:
E-mail: senm@upmc.edu
Education and Training
Education
PhD., Biochemistry, Calcutta University, India, 2001
MS., Biochemistry, North Eastern Hill University, Shillong, India, 1993
BS., Chemistry, North Eastern Hill University, Shillong, India, 1991
Training
Postdoctoral, University of Pittsburgh, 2005
Postdoctoral, University of Nebraska Medical Center, 2004
Postdoctoral, Saha Institute of Nuclear Physics, Kolkata, India, 2001
Research Interest
The focus of our research is cancer epigenetics with an emphasis on lung cancer. The current work involves understanding and characterizing epigenetic changes in cancer, developing therapeutic strategies based upon epigenetic alterations and developing alterations in DNA methylation for use as predictive biomarkers and early detection of lung cancer. The aim of our work is to elucidate epigenetic alterations and investigate mechanisms in a series of preclinical models based on the key observations from the clinic and use therapeutic strategies to predict sensitivity for the development of clinically relevant biomarkers.
Publications
Selected Publications:
Johnston, P.A, Sen, M, Hua, Y, Camarco, D.P, Shun, D.Y, Lazo, J.S, Grandis, J.R. High Content Imaging Assays for IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines. Methods in Molecular Biology. 2018; 1683: 229-244.
Sen, M, Johnston, P.A, Pollock, N.I, DeGrave, K, Joyce, S.C, Freilino, M.L, Hua, Y, Camarco, D.P, Close, D.A, Huryn, D.M, Wipf, P, Grandis, J.R. Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines. Journal of Chemical Biology. 2017; 10(3): 129-141.
Bauman, J.E, Duvvuri, U, Gooding, W.E, Rath, T.J, Gross, N.D, Song, J, Jimeno, A, Yarbrough, W.E, Johnson, F.M, Wang, L, Chiosea, S, Sen, M, Kass, J, Johnson, J.T, Ferris, R.L, Kim, S, Hirsch, F.R, Ellison, K, Mills, G.B, Grandis, J.R. Randomized, placebo-controlled window trial of EGFR, Src, or combined blockade in head and neck cancer. Journal of Clinical Investigation. 2016; 2(6): e90449.
Bauman, J.E, Zang, Y, Sen, M, Li, C, Wang, L, Egner, P.A, Fahey, J.W, Normolle, D.P, Grandis, J.R, Kensler, T.W, Johnson, D.E. Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane. Cancer Prevention Research. 2016; 9(7): 547–557.
Peyser, N.D, Wang, L, Zeng, Y, Acquafondata, M, Freilino, M, Li, H, Sen, M, Gooding, W.E, Satake, M, Wang, Z, Johnson, D.E, Grandis, J.R. STAT3 as a chemoprevention target in carcinogen-induced head and neck squamous cell carcinoma. Cancer Prevention Research. 2016; 9(8): 657–663.
Kiesel, B.F, Parise, R.A, Guo, J, Huryn, D.M, Johnston, P.A, Colombo, R, Sen, M, Grandis, J.R, Beumer, J.H, Eiseman, J.L. Toxicity, pharmacokinetics and metabolism of a novel inhibitor of IL-6-induced STAT3 activation. Cancer Chemotherapy and Pharmacology. 2016; 78(6): 1225–1235.
Kopechek, J.A, Carson., A.R, McTiernan, C.F, Chen, X, Hasjim, B, Lavery, L, Sen, M, Grandis, J.R, Villanueva, F.S. Ultrasound Targeted Microbubble Destruction-Mediated Delivery of a Transcription Factor Decoy Inhibits STAT3 Signaling and Tumor Growth. Theranostics. 2015; 5(12): 1378-1387.
Sen M, Paul K, Freilino ML, Li H, Li C, Johnson DE, Want L, Eiseman J, Grandis JR. Systemic Administration of a Cyclic STAT3 Decoy Oligonucleotide Inhibits Tumor Growth Without Inducing Toxicological Effects. Molecular Medicine. 2014; 20: 46-56.
Sen M, Thomas SM, Kim S, Yeh JI, Ferris RL, Johnson JT, Duvvuri U, Lee J, Sahu N, Joyce S, Freilino ML, Shi H, Li C, Ly D, Rapireddy S, Etter JP, Li PK, Wang L, Chiosea S, Seethala RR, Gooding WE, Thomas SM, Johnson DE, Grandis JR. First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy. Cancer Chemotherapy and Pharmacology. 2012; 63: 983-95.
Sen, M, Joyce, S, Panahandeh, M, Li, C, Thomas, S.M, Maxwell, J, Wang, L, Gooding, W.E, Johnson, D.E, Grandis, J.R. Targeting STAT3 abrogates EGFR inhibitor resistance in cancer. Clinical Cancer Research. 2012; 18(18): 4986–4996.
Notable Achievements
Presenter, The American Society for Investigative Pathology, 2017
Fellowship from Ministry of Food and Civil Supplies, 2000-2001
Dayabhai Vadalia Memorial Award by Oil Technologists Association of Indian, 2000
Fellowship from Indian Council of Medical Research, New Delhi, India, 1997-2000
Fellowship from Department of Science and Technology, Kolkata, India, 1995-1997