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Department of Medicine

Department of Medicine

  Division of Hematology/Oncology

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photo Malabika Sen, PhD

Research Assistant Professor

Email: senm@upmc.edu

Phone: 412-623-7821

Contact
Office: 2.7, Hillman Cancer Center
5115 Centre Avenue
Pittsburgh, PA 15232
 
Phone: 412-623-7821
Fax:
E-mail: senm@upmc.edu
Education and Training
Education
BS., Chemistry, North Eastern Hill University, Shillong, India, 1991
MS., Biochemistry, North Eastern Hill University, Shillong, India, 1993
PhD., Biochemistry, Calcutta University, India, 2001
Training
Postdoctoral, Saha Institute of Nuclear Physics, Kolkata, India, 2001
Postdoctoral, University of Nebraska Medical Center, 2004
Postdoctoral, University of Pittsburgh, 2005
Research Interest
The focus of our research is cancer epigenetics with an emphasis on lung cancer. The current work involves understanding and characterizing epigenetic changes in cancer, developing therapeutic strategies based upon epigenetic alterations and developing alterations in DNA methylation for use as predictive biomarkers and early detection of lung cancer. The aim of our work is to elucidate epigenetic alterations and investigate mechanisms in a series of preclinical models based on the key observations from the clinic and use therapeutic strategies to predict sensitivity for the development of clinically relevant biomarkers.
Publications
Selected Publications:
Johnston PA, Sen M, Hua Y, Camarco DP, Shun TY, Lazo JS, Wilson GM, Resnick LO, LaPorte MG, Wipf P, Huryn DM, Grandis JR. HCS campaign to identify selective inhibitors of IL-6 induced STAT3 pathway activation in head and neck cancer cell lines. Assay Drug Developmental Technology. 2015; 13(7): 356-76.
Sen M, Pollock NI, Black J, DeGrave KA, Wheeler S, Freilinio ML, Joyce S, Lui VWY, Zeng Y, Chiosea SI, Grandis JR. Jak kinase inhibition abrogates STAT3 activation and head and neck squamous cell carcinoma tumor growth. Neoplasia. 2015; 17(3): 256-64.
Johnston PA, Sen M, Hua Yq, Camarco D, Shun TY, Lazo JS, Grandis JR. High Content pSTAT3/1 Imaging Assays to Screen for Selective Inhibitors of STAT3 Pathway Activation in Head and Neck Cancer Cell Lines. Assay Drug Developmental Technology. 2014; 12(1): 55-79.
Sen M, Paul K, Freilino ML, Li H, Li C, Johnson DE, Want L, Eiseman J, Grandis JR. Systemic Administration of a Cyclic STAT3 Decoy Oligonucleotide Inhibits Tumor Growth Without Inducing Toxicological Effects. Molecular Medicine. 2014; 20: 46-56.
Sen M, Grandis JR. Nucleic acid-based approaches to STAT inhibition. JAK/STAT Signaling Pathway. 2012; 1: 285-291.
Sen M, Joyce S, Panahandeh M, Li C, Thomas SM, Maxwell J, Wang L, Johnson DE, Grandis JR. Targeting STAT3 abrogates EGFR inhibitor resistance in cancer. Clinical Cancer Research. 2012; 18: 4986-96.
Sen M, Thomas SM, Kim S, Yeh JI, Ferris RL, Johnson JT, Duvvuri U, Lee J, Sahu N, Joyce S, Freilino ML, Shi H, Li C, Ly D, Rapireddy S, Etter JP, Li PK, Wang L, Chiosea S, Seethala RR, Gooding WE, Thomas SM, Johnson DE, Grandis JR. First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy. Cancer Chemotherapy and Pharmacology. 2012; 63: 983-95.
Sen M, Tosca PJ, Zwayer C, Ryan MJ, Johnson JD, Knostman KAB, Gielas PC, Welch AR, Peggins JO, Tomaszewski JE, McMurray TP, Li C, Leibowtiz MS, Ferris RL, Gooding WE, Thomas SM, Johnson DE, Grandis JR. Lack of toxicity of a STAT3 decoy oligonucleotide,. Cancer Chemotherapy and Pharmacology. 2009; 73: 1632-42.
Boehm AL, Sen M, Seethala R, Gooding WE, Freilino M, Wong SM, Wang S, Johnson DE, Grandis JR. Combined Targeting of EGFR, STAT3, and Bcl-XL Enhances Antitumor Effects in Squamous Cell Carcinoma of the Head and Neck. Molecular Pharmacology. 2008; 73: 1632-42.
Sen M, McHugh K, Hutzley J, Philips BJ, Chir R, Parwani AV, Kelavkar UP. Orthotopic expression of human 15-lipoxygenase (LO)-1 in the dorsolateral prostate of normal wild-type C57BL/6 mouse causes PIN-like lesions. Prostaglandins Other Lipid Mediat. 2006; 81: 1-13.
Notable Achievements
Fellowship from Department of Science and Technology, Kolkata, India, 1995-1997
Fellowship from Indian Council of Medical Research, New Delhi, India, 1997-2000
Fellowship from Ministry of Food and Civil Supplies, 2000-2001
Dayabhai Vadalia Memorial Award by Oil Technologists Association of Indian, 2000