Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles
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photo Anna E Lokshin, PhD

Hematology/Oncology

Professor of Medicine, Pathology, and Ob/Gyn RS

Director, Luminex Core Facility

Email: lokshina@pitt.edu

Phone: 412-623-7706
Contact
Office: Hillman Cancer Center
5117 Centre Ave, Suite 1.19d
Pittsburgh, PA 15213
 
Phone: 412-623-7706
Fax: 412-623-1415
E-mail: lokshina@pitt.edu
Administrative Assistant:
Dianna Fennel
Address: 5117 Centre Avenue
UPMC Hillman Cancer Center, Suite 1.19
Pittsburgh, PA 15213
Email: pappertfenneld@upmc.edu
Phone: 412-623-1114
Fax: 412-623-1415
Education and Training
Education
PhD, University of Leningrad, 1983
MS, University of Leningrad, 1977
BS, University of Leningrad, 1974
Research Interest
My research is centered around discovery and characterization of biomarkers for screening, diagnosis, and prognosis of cancer, in particular, ovarian and pancreatic cancers. My group has identified biomarker combinations that recognize ovarian cancer 1-4 years earlier than current methods (CA125 and transvaginal ultrasound) and pancreatic cancer – 2-6 years earlier. We are working on discovering biomarkers in several bodily fluids including serum/plasma and urine and in exosomes obtained from these fluids.
In additional, we are investigating the pre-neoplastic microenvironment in high-grade serous ovarian carcinoma, and the role of glycolysis and coagulation pathways in the early preneoplastic events of high-grade serous ovarian carcinoma and the role of exosomes in these events.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Mirus JE, Zhang Y, Li CL, et al. Cross-species antibody microarray interrogation identifies a 3-protein panel of plasma biomarkers for early diagnosis of pancreas cancer. Cancer Research. 2015; 21: 1764-71.
Nolen, BM, Lomakin A, Marrangoni A, Velikokhatnaya L, Prosser D, Lokshin AE. Urinary protein biomarkers in the early detection of lung cancer. Cancer Prevention Research. 2015; 8: 111-9.
Nolen BM, Brand RE, Prosser D, et al. Prediagnostic serum biomarkers as early detection tools for pancreatic cancer in a large prospective cohort study. PloS one. 2014; 9: e94928.
Nolen BM, Orlichenko LS, Marrangoni A, et al. An extensive targeted proteomic analysis of disease-related protein biomarkers in urine from healthy donors. PloS one. 2013; 8: e63368.
Bigbee WL, Gopalakrishnan V, Weissfeld JL, et al. A multiplexed serum biomarker immunoassay panel discriminates clinical lung cancer patients from high-risk individuals found to be cancer-free by CT screening. Journal of thoracic oncology. Official publications of ther Internaional Association for the Study of Lung Cancer. 2012; 7: 698-708.
Clendenen TV, Lundin E, Zeleniuch-Jacquotte A, et al. Circulating inflammation markers and risk of epithelial ovarian cancer. Cancer epidemiology, biomarkers & prevention :. American Association for Cancer Research. 2011; 20: 799-810.
Al Efishat, M.A., Attiyeh, M.F., Eaton, A.A., Gönen, M., Prosser, D., Lokshin, A.E., Castillo, C.F., Lillemoe K,D., Ferrone, C.R., Pergolini, I., Mino-Kenudson, M., Rezaee, N., Dal Molin, M., Weiss, M.J., Cameron, J.L., Hruban, R.H., D'Angelica, M.I., Jarnagin, W.R., Wolfgang, C.L., Allen, P.J. Multi-Institutional Validation Study of Pancreatic Cyst Fluid Protein Analysis for Prediction of High-Risk Intraductal Papillary Mucinous Neoplasms of the Pancreas. Annals of Surgery. 2017.
Shurin, M.R., Ma, Y., Keskinov, A.A., Zhao, R., Lokshin, A., Agassandian, M., Shurin, G.V. BAFF and APRIL from Activin A-Treated Dendritic Cells Upregulate the Antitumor Efficacy of Dendritic Cells In Vivo. Cancer Research. 2016; 76: 4959-69.
Kim, S.H., Hahm, E.R., Arlotti, J.A., Samanta, S.K., Moura, M.B., Thorne, S.H., Shuai, Y., Anderson, C.J., White, A.G., Lokshin, A., Lee, J., Singh, S.V. Withaferin A inhibits in vivo growth of breast cancer cells accelerated by Notch2 knockdown. Breast Cancer Research. 2016; 157: 41-54.
Notable Achievements
Member Oncology 2 - Translational Clinical (OTC) NIH study section, 2017-present
Member, Ad Hoc review team; STTR/SBIR, U01,Omnibus, 2006-present
Associate editor, Cancer Biomarkers, 2004-present
Associate editor, Cancers, 2018-oresent

Division Websites

Cardiology

Endocrinology and Metabolism

Gastroenterology, Hepatology and Nutrition

General Internal Medicine

Geriatric Medicine
Hematology/Oncology

Infectious Diseases

Pulmonary, Allergy and Critical Care Medicine

Renal-Electrolyte

Rheumatology and Clinical Immunology

Contact

Department of Medicine
1218 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Email:  chairoff@pitt.edu
Phone:  412-648-9636
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