Department of Medicine

Department of Medicine

  Division of Hematology/Oncology

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photo Anna E Lokshin, PhD

Professor of Medicine, Pathology, and Ob/Gyn RS

Director, Luminex Core Facility


Phone: 412-623-7706

Office: Hillman Cancer Center
5117 Centre Ave, Suite 1.19d
Pittsburgh, PA 15213
Phone: 412-623-7706
Fax: 412-623-1415
Administrative Assistant:
Dianna Fennel
Address: 5117 Centre Avenue
UPMC Hillman Cancer Center, Suite 1.19
Pittsburgh, PA 15213
Phone: 412-623-1114
Fax: 412-623-1415
Education and Training
PhD, University of Leningrad, 1983
MS, University of Leningrad, 1977
BS, University of Leningrad, 1974
Research Interest
My research is centered around discovery and characterization of biomarkers for screening, diagnosis, and prognosis of cancer, in particular, ovarian and pancreatic cancers. My group has identified biomarker combinations that recognize ovarian cancer 1-4 years earlier than current methods (CA125 and transvaginal ultrasound) and pancreatic cancer – 2-6 years earlier. We are working on discovering biomarkers in several bodily fluids including serum/plasma and urine.
For my complete bibliography, Click Here.
Selected Publications:
Mirus JE, Zhang Y, Li CL, et al. Cross-species antibody microarray interrogation identifies a 3-protein panel of plasma biomarkers for early diagnosis of pancreas cancer. Cancer Research. 2015; 21: 1764-71.
Nolen, BM, Lomakin A, Marrangoni A, Velikokhatnaya L, Prosser D, Lokshin AE. Urinary protein biomarkers in the early detection of lung cancer. Cancer Prevention Research. 2015; 8: 111-9.
Nolen BM, Brand RE, Prosser D, et al. Prediagnostic serum biomarkers as early detection tools for pancreatic cancer in a large prospective cohort study. PloS one. 2014; 9: e94928.
Nolen BM, Orlichenko LS, Marrangoni A, et al. An extensive targeted proteomic analysis of disease-related protein biomarkers in urine from healthy donors. PloS one. 2013; 8: e63368.
Bigbee WL, Gopalakrishnan V, Weissfeld JL, et al. A multiplexed serum biomarker immunoassay panel discriminates clinical lung cancer patients from high-risk individuals found to be cancer-free by CT screening. Journal of thoracic oncology. Official publications of ther Internaional Association for the Study of Lung Cancer. 2012; 7: 698-708.
Clendenen TV, Lundin E, Zeleniuch-Jacquotte A, et al. Circulating inflammation markers and risk of epithelial ovarian cancer. Cancer epidemiology, biomarkers & prevention :. American Association for Cancer Research. 2011; 20: 799-810.
Notable Achievements
Member K-awards NIH study section, 2012-2016
Member, Ad Hoc review team; STTR/SBIR, U01,Omnibus, 2006-present
Associate editor, Cancer Biomarkers, 2004-present