Department of Medicine

Department of Medicine

  Division of Hematology/Oncology

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photo James J. Lee, MD, PhD

Associate Professor of Medicine


Phone: 412-648-6586

Office: UPMC Cancer Pavilion,
5150 Centre Avenue, Fifth Floor, Room 568
Pittsburgh, PA 15232
Phone: 412-648-6586
Fax: 412-648-6579
Administrative Assistant:
Lois Malehorn
Address: 5150 Centre Avenue
5th floor
Pittsburgh, PA 15232
Phone: 412-648-6589
Fax: 412-648-6579
Education and Training
M.D., Seoul National University, 1988
Ph.D. in Immunology, Johns Hopkins University School of Medicine, 2000
Residency in Internal Medicine, Albert Einstein College of Medicine, 2003
Medical Oncology Fellowship, National Cancer Institute, 2005
Research Interest
The primary focus of my research has been on early-phase clinical studies of novel agents in colorectal cancer and other solid tumors, and clinical development of immunotherapy for the treatment of metastatic colorectal cancer.
Clinical Interest
James J. Lee, MD, PhD, is a medical oncologist who specializes in early phase drug development (phase I clinical trials) of new cancer drugs and the treatment of colon cancer. His research has been focused on the development of new cancer drugs including cytotoxic chemotherapeutic agents and immunotherapy. He also has a strong interest in the translational research of colorectal cancer
For my complete bibliography, Click Here.
Selected Publications:
Lee JJ, Seraj J, Yoshida K, Mizuguchi H, Strychor S, Fiejdasz J, Faulker T, Pollice L, Mason S, Sun W, Chu E, Croft M, Nugteren J, Tedder T, Beumer JH. Human mass balance study of TAS-102 using 14C analyzed by accelerator mass spectrometry. Cancer Chemotherapy and Pharmacology. 2016; 77(3): 515-26.
Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, Skora AD, Luber BS, Azad NS, Laheru D, Biedrzycki B, Donehower RC, Zaheer A, Fisher GA, Crocenzi TS, Lee JJ, Duffy SM, Goldberg RM, de la Chapelle A, Koshiji M, Bhaijee F, Huebner T, Wood LD, Cuka N, Pardoll DM,Papadopoulos N, Kinzler KW, Zhou S, Cornish TC, Taube JM Anders RA, Eshleman JR, Vogelstein B, Diaz LA, Jr. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. New England Journal of Medicine. 2015; 372(26): 2509-20.
Lee JJ, Chu E. Sequencing of antiangiogenic agents in the treatment of metastatic colorectal cancer. Clinical Colorectal Cancer. 2014; 13(3): 135-55.
Lee JJ, Kelly WK. Epothilones: tubulin polymerization as a novel target for prostate cancer therapy. Nature Clinical Practice Oncology. 2009; 6(2): 85-92.
Lee JJ, Swain SM. The epothilones: translating from the laboratory to the clinic. Clinical Cancer Research. 2008; 14(6): 1618-24.
Lee JJ, Chu E. First-line use of anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer. Clinical Colorectal Cancer. 2007; 6(2): S42-6.
Lee JJ, Swain SM. Peripheral neuropathy induced by microtubule-stabilizing agents. Journal of Clinical Oncology. 2006; 24(10): 1633-42.
Lee JJ, Chu E. An update on treatment advances for the first-line therapy of metastatic colorectal cancer. Cancer Journal. 2007; 13(5): 276-81.
Lee JJ, Low JA, Croarkin E, Parks R, Berman AW, Mannan N, Steinberg SM, Swain SM. Changes in neurologic function tests may predict neurotoxicity caused by ixabepilone. Journal of Clinical Oncology. 2006; 24(13): 2084-91.
Lee J, Desiderio S. Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair. Immunity. 1999; 11(6): 771-81.
Notable Achievements
Member, NCI Colon Cancer Task Force of Gastrointestinal Cancer Steering Committee (GISC), 2016-present
Member, NRG Oncology Colorectal Cancer Core Committee, 2016-present
Editorial Board, Clinical Colorectal Cancer, 2006-present