Department of Medicine

University of Pittsburgh

Division of Gastroenterology, Hepatology and Nutrition
Mezzanine Level,
200 Lothrop Street
Pittsburgh, PA 15213
Phone: (412) 648-9115

Stephen J.D. O'Keefe, MD, MSc


Professor of Medicine

Medical Director, Small Intestinal Rehabilitation &Transplant Center

Clinical Nutrition Service

Office: PUH - Mezz. 2 - C Wing
200 Lothrop St.
Pittsburgh, PA 15213
Phone: 412-648-7217
Fax: 412-383-8913

MB BS, Guy's Hospital Medical School, London, England, 1966
MRCS and LRCP, Royal College of Physicians, London, England
MSc, London University, 1972
MD (by thesis, equivalent to PhD), London University, 1981

Fellowship, Intern. Med. & Nutrition, Harvard Medical School, 1990

Area of Specialization/Research Interest  
Nutrition and Disease
Nutritional Gastroenterology
Acute Pancreatitis
Intestinal Rehabilitation and Transplantation
Nutrion and Colon Cancer
Nutritional Support

Dr O’Keefe’s research is in the field of nutritional gastroenterology. Most of his investigations are translational in nature, evaluating the physiological and pathophysiological responses to dietary intake and interventional feeding. He has had NIH funding for his studies on the effects of enteral and parenteral feeding on the synthesis and secretion of trypsin in humans which have formed the basis for his latest NIH funded multicenter study on distal jejunal feeding in acute pancreatitis. He has applied stable isotope labeling techniques to the study of in vivo amino acid turnover and protein synthesis, with particular attention to the measurement of mucosal protein turnover and the synthesis of trypsin in patients with acute severe pancreatitis. His second area of current interest is the management of short bowel by enteral and IV feeding, and by small bowel transplantation. Third, he is investigating the influence of diet on colonic bacterial metabolism and colon cancer risk.

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