Department of Medicine

Department of Medicine

  Division of Gastroenterology, Hepatology and Nutrition

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photo Stephen J.D. O'Keefe, MD, MSc


Phone: 412-648-7217

Office: Division of Gastroenterology, Hepatology & Nutrition- 200 Lothrop St
UPMC Presbyterian Hospital/ 853 Scaife Hall
Pittsburgh, PA 15213
Phone: 412-648-7217
Fax: 412-383-8913
Education and Training
MB BS, Guy's Hospital Medical School, London, England, 1966
MRCS and LRCP, Royal College of Physicians, London, England
MSc, London University, 1972
MD (by thesis, equivalent to PhD), London University, 1981
Fellowship, Intern. Med. & Nutrition, Harvard Medical School, 1990
Research Interest
A Professor of Medicine, Dr. O'Keefe's research is focused on physiological and pathophysiological nutritional responses to dietary intake and interventional feeding. These efforts focus on the relationship between diet, the colonic microbiota, and colon cancer risk, particularly among African vs. African American populations.
For my complete bibliography, Click Here.
Selected Publications:
Hegazi, R., Raina, A., Graham, T., Rolniak, S., Centa, P., Kandil, H., O'Keefe, S.J. Early jejunal feeding initiation and clinical outcomes in patients with severe acute pancreatitis. Journal of Parental and Enteral Nutrition. 2011; 35(2): 276.
Ou, J., DeLany, J.P., Zhang, M., Sharma, S., O'Keefe, S.J. Association between low colonic short-chain fatty acids and high bile acids in high colon cancer risk populations. Nutrition and Cancer. 2012; 64(1): 34-40.
O'Keefe, S.J., Ou, J., Delany, J.P., Curry, S., Zoetendal, E., Gaskins, H.R., Gunn, S. Effect of fiber supplementation on the microbiota in critically ill patients. World Journal of Gastrointestinal Pathophysiology. 2011; 2(6): 138-45.
O'Keefe, S.J., El Hajj II, Wu, T., Martin, D., Mohammed, K., Abu-Elmagd, K. Endoscopic evaluation of small intestine transplant grafts. Transplantation. 2012; 94(7): 757-62.
Ou, J., Carbonero, F., Zoetendal, E.G., DeLany, J.P., Wang, M., Newton, K., Gaskins, H.R., O'Keefe, S.J. Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans. The American Journal of Clinical Nutrition. 2013; 98(1): 111-20.
Bakker, O.J., van Brunschot, S., Farre, A., Johnson, C.D., Kalfarentzos, F., Louie, B.E., Olah, A., O'Keefe, S.J., Petrov, M.S., Powell, J.J., Besselink, M.G., van Santvoort, H.C., Rovers, M.M., Gooszen, H.G. Timing of enteral nutrition in acute pancreatitis: meta-analysis of individuals using a single-arm of randomised trials. Pancreatology. 2014; 14(5): 340-6.
Vipperla, K., O'Keefe S.J. Targeted therapy of short-bowel syndrome with teduglutide: the new kid on the block. Journal of Clinical and Experimental Gastroenterology. 2014; 7: 489-95.
O'Keefe, S.J., Li, J.V., Lahti, L., Ou, J., Carbonero, F., Mohammed, K., Posma, J.M., Kinross, J., Wahl, E., Ruder, E., Vipperla, K., Naidoo, V., Mtshali, L., Tims, S., Puylaert, P,G,, DeLany, J., Krasinskas, A., Benefiel, A.C., Kaseb, H.O., Newton, K. Fat, fibre and cancer risk in African Americans and rural Africans. Nature Communications. 2015; 6: 6342.
Vipperla, K., O'Keefe S.J. Diet, microbiota, and dysbiosis: a 'recipe' for colorectal cancer. Food and Function. 2016; 7(4): 1731-40.
Schwartz, L.K., O'Keefe, S.J., Fujioka, K., Gabe, S.M., Lamprecht, G., Pape, U.F., Li, B., Youssef, N.N., Jeppesen, P.B. Long-Term Teduglutide for the Treatment of Patients with Intestinal Failure Associated with Short Bowel Syndrome. Clinical and Translational Gastroenterology. 2016; 7: e142.
Sponsored Research/Activities
Title: Diet and Gastrointestinal Cancer Risk in African Americans and Rural Africans
Role: Principal Investigator
Funding Agency: National Cancer Institute
Grant Number: R01 CA135379
Start Year: 2009
End Year: 2014
Title: Pancreatic Enzyme Supplements to Restore Digestive Function in Malnourished Gastric-Bypass Patients
Role: Principal Investigator
Funding Agency: Solvay Pharmaceuticals
Grant Number: DRUG
Start Year: 2007
End Year: 2013
Notable Achievements
NCI-NIH Study Sections (special interest groups and programs), 2013 - Present
AGA Nominating Committee (Nutrition and Obesity Section), 2013 - Present
Editorial Board Gastroenterology Research and Practice, 2013 - Present
Assistant Editor-in-Chief: World Journal of Gastroenterology, 2011 - Present
Associate Editor: Frontiers in Gastroenterology Physiology and Science, 2010 - Present
South African Gastroenterology Society (Elect Council Member), 1992 - Present
The Leist Visiting Professorship, Mayo Clinic, Nutrition and the Quality of Life following Small, 2006