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Department of Medicine

Department of Medicine

  Division of Gastroenterology, Hepatology and Nutrition

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photo Michael Andrew Dunn, MD, FACP

Associate Chief for Translational Research

Joint Appointment, Professor of Biomedical Informatics

Email: dunnma@upmc.edu

Phone: 412-647-4932

Contact
Office: Division of Gastroenterology, Hepatology & Nut ( CLD) Center for Liver Diseases
3471 5th Ave 916 Lillian Kaufmann Building
Pittsburgh, PA 15213
 
Phone: 412-647-4932
Fax: 412-647-9268
E-mail: dunnma@upmc.edu
Administrative Assistant:
Cathy Freehling
Address: Division of Gastroenterology, Hepatology & Nutrition ( CLD) Center for Liver Diseases
3471 5th Ave 916 Lillian Kaufmann Bld
Pittsburgh, PA 15213
Phone: 412-647-4932
Fax: 412-647-9268
Administrative Assistant:
Ann Menke
Address: Division of Gastroenterology, Hepatology & Nutrition ( CLD) Center for Liver Diseases
3471 5th Ave, 916 Lillian Kaufmann Bld
Pittsburgh, PA 15213
Email: menkeaa@upmc.edu
Phone: 412-802-3162
Fax: 412-647-9268
Education and Training
Education
BS, University of Notre Dame, 1968
MD, Northwestern University Medical School, 1971
Training
Medical Internship, University of Michigan Medical Center, Ann Arbor, MI, 1972
Medical Residency, Hospital of the University of Pennsylvania, Philadelphia, PA, 1974
Gastroenterology Fellowship, Albert Einstein College of Medicine, Bronx, NY, 1977
Research Interest
Dr. Dunn is a Professor of Medicine. In collaboration with colleagues of the Thomas E Starzl Transplantation Institute and the School of Health and Rehabilitation Sciences, he leads a UPMC hospital-funded initiative to improve the fitness and activity of liver transplant candidates with the objective of producing a 20% decrease in waitlist hospital days and waitlist mortality. Wearable personal activity monitoring and quantitation of muscle mass with imaging segmentation analysis are being explored as enabling technologies.

Dr. Dunn formed and now leads the FLEXIT (Fitness, Life Enhancement and Exercise in Transplantation) Consortium of investigators at the University of California San Francisco, Mayo Clinic Arizona, Cleveland Clinic, Duke University, University of Alberta, and University of Pittsburgh, engaged in multi-center collaborations to define, prevent and reverse physical decline in cirrhosis.

Dr. Dunn helped Dr. David Binion design and continue to assist in operating a Department of Defense supported searchable prospective electronic clinical registry for our inflammatory bowel disease team. It has enabled significant advances in disease modeling with over 20 major publications in the last 3 years.

He also serves as the site Principal Investigator of an industry-sponsored FDA registration trial of obeticholic acid therapy for primary sclerosing cholangitis.
Clinical Interest
I am a hepatologist and Associate Chief for Translational Research of the Division of Gastroenterology, Hepatology and Nutrition. My major current interest is understanding, preventing and reversing physical decline and muscle wasting in cirrhosis, the major cause of death and waitlist attrition in liver transplantation. I am experienced in analysis of data from electronic records for improved predictive modeling and decision support.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Dunn, M.A., Rojkind, M., Warren, K.S., Hait, P.K., Rifas, L., Seifter, S. Liver collagen synthesis in murine schistosomiasis. The Journal of Clinical Investigation. 1977; 59(4): 666-74.
Dunn, M.A., Sidell, F.R. Progress in medical defense against nerve agents. The Journal of the American Medical Association. 1989; 262(5): 649-52.
Keeler, J.R., Hurst, C.G., Dunn, M.A. Pyridostigmine used as a nerve agent pretreatment under wartime conditions. The Journal of the American Medical Association. 1991; 266(5): 693-5.
Dunn, M.A., Cheever, A.W., Paglia, L.M., Kelly, E.P., Duvall, R.H., Andrade, Z.A., Goldner, F.H. Reversal of advanced liver fibrosis in rabbits with Schistosomiasis japonica. The American Journal of Tropical Medicine and Hygiene. 1994; 50(4): 499-505.
Dunn, M.A., Behari, J., Rogal, S.S., O'Connell, M.R., Furlan, A., Aghayev, A., Gumus, S., Saul, M.I., Bae, K.T. Hepatic steatosis in diabetic patients does not predict adverse liver-related or cardiovascular outcomes. Liver International. 2013; 33(10): 1575-82.
Bergerson, J.T., Lee, J.G., Furlan, A., Sourianarayanane, A., Fetzer, D.T., Tevar, A.D., Landsittel, D.P., DiMartini, A.F., Dunn, M.A. Liver transplantation arrests and reverses muscle wasting. Clinical Transplantation. 2015; 29(3): 216-21.
Chhatwal, J., Kanwal, F., Roberts, M.S., Dunn, M.A. Cost-effectiveness and budget impact of hepatitis C virus treatment with sofosbuvir and ledipasvir in the United States. Annals of Internal Medicine. 2015; 162(6): 397-406.
Chen, H.W., Dunn, M.A. Muscle at Risk: The Multiple Impacts of Ammonia on Sarcopenia and Frailty in Cirrhosis. Clinical and Translational Gastroenterology. 2016; 7: e170.
Dunn, M.A., Josbeno, D.A., Schmotzer, A.R., Tevar, A.D., DiMartini, A.F., Landsittel, D.P., Delitto, A. The Gap Between Clinically Assessed Physical Performance and Objective Physical Activity in Liver Transplant Candidates. Liver Transplantation. 2016.
Dunn, M., Josbeno, A., Deborah, A., Tevar, A., Amit, D., Rachakonda, V., Ganesh, S., Swaytha, R, Schmotzer, A., Kallenborn, R., Elizabeth, A., Behari, J. Frailty as tested by gait speed is an independent risk factor for cirrhosis complications that require hospitalization. The American Journal of Gastroenterology. 2016.
Sponsored Research/Activities
Title: Framework for Smart Electronic Health Record-Linked Predictive Models to Optimize Care for Complex Digestive Diseases
Role: Principal Investigator
Funding Agency: Department of Defense
Start Year: 2011
End Year: 2014
Title: Utilizing Clinical Metadata to Predict High-cost Complications and Treatment Response in IBD: Development of Clinical Decision Support Tools
Role: Co-Investigator
Funding Agency: Department of Defense
Start Year: 2017
End Year: 2020
Title: The Economic and Clinical Impact of Hepatitis C Treatment on Pennsylvania Medicaid
Role: Co-Investigator
Funding Agency: Commonwealth of Pennsylvania
Start Year: 2014
End Year: 2015
Notable Achievements
Military service 28 years, including command of the Walter Reed Health Care System and all military hospitals in the Western US, completed service as an Army Brigadier General, 1977-2005
Senior Medical Advisor to the Secretary of DHHS for protection of the US population from terrorist weapons of mass destruction, 2006-2012
American Association for the Study of Liver Diseases, Governmental Liaison Committee, 2015-present
General Lewis A Mologne Award as the Army's outstanding senior clinical teacher, 1999
Laureate, Army Chapter, American College of Physicians, 2006
Military awards: Army Distinguished Service Medal, Bronze Star, 14 others, 1991-2005