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Department of Medicine

Department of Medicine

  Division of Gastroenterology, Hepatology and Nutrition

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photo Richard H. Duerr, MD

Inflammatory Bowel Disease Genetic Research Chair

Professor of Medicine, Human Genetics, and Clinical and Translational Science

Co-Director and Scientific Director, UPMC Inflammatory Bowel Disease Center

Email: duerr@pitt.edu

Phone: 412-648-9497

Contact
Office: Division of Gastroenterology, Hepatology & Nutrition - 200 Lothrop St
UPMC Presbyterian/ BSTWR- S704
Pittsburgh, PA 15213
 
Phone: 412-648-9497
Fax: 412-383-8864
E-mail: duerr@pitt.edu
Administrative Assistant:
Diane Pochron
Address: Division of Gastroenterology, Hepatology & Nut
Medical Arts Building 3708 5th Ave, Suite 401.5
Pittsburgh, PA 15213
Email: pochrond@pitt.edu
Phone: 412-578-9515
Fax: 412-578-9547
Education and Training
Education
BS, University of Minnesota - Duluth, 1979
MD, University of Minnesota, 1983
Training
Training Program in Internal Medicine, University of California at San Francisco, 1986
Integrated Training Program in Digestive Diseases, University of California at Los Angeles, 1990
Research Interest
Richard H. Duerr, MD, holds the Inflammatory Bowel Disease Genetic Research Chair and is Professor of Medicine, Human Genetics, and Clinical and Translational Science at the University of Pittsburgh. He is the Co-Director and Scientific Director of the University of Pittsburgh Medical Center Inflammatory Bowel Disease Center.

Dr. Duerr has been involved in research related to inflammatory bowel disease throughout his career. He leads one of six genetic research centers that comprise the NIH/NIDDK Inflammatory Bowel Disease Genetics Consortium. His research program has had uninterrupted funding from the NIH, CCFA, and other foundations since 1995. He was recently appointed Associate Chief Scientist, Translational Research on the Leadership Team of the Crohn’s & Colitis Foundation of America (CCFA) IBD Plexus research and information exchange platform that will engage academic and industry researchers, IBD patients, and clinicians and other healthcare providers in a partnership to accelerate the science of IBD.

Dr. Duerr is a member of the American Gastroenterological Association, the American Society of Human Genetics, and CCFA. He has been an invited lecturer in local, national and international venues, and he has published original inflammatory bowel disease genetics research articles in journals such as Nature, Science, Nature Genetics, American Journal of Human Genetics, and Human Molecular Genetics. He has served on grants review committees for the NIH and CCFA.
Clinical Interest
Inflammatory Bowel Disease
Publications
For my complete bibliography, Click Here.
Selected Publications:
Silverberg, M.S., Cho, J.H., Rioux, J.D., McGovern, D.P., Wu, J., Annese, V., Achkar, J.P., Goyette, P., Scott, R., Xu, W., Barmada, M.M., Klei, L., Daly, M.J., Abraham, C., Bayless, T.M., Bossa, F., Griffiths, A.M., Ippoliti, A.F., Lahaie, R.G., Latiano, A. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nature Genetics. 2009; 41(2): 216-20.
Achkar, J.P., Klei, L., de Bakker, P.I., Bellone, G., Rebert, N., Scott, R., Lu, Y., Reguiero, M., Brzezinski, A., Kamboh, M.I., Fiocchi, C., Devlin, B., Trucco, M., Ringquist, S., Roeder, K., Duerr, R.H. Amino acid position 11 of HLA-DRB1 is a major determinant of chromosome 6p association with ulcerative colitis. Genes and Immunity. 2012; 13(3): 245-52.
Jostins, L., Ripke, S., Weersma, R.K., Duerr, R.H., McGovern, D.P., Hui, K.Y., Lee, J.C., Schumm, L.P., Sharma, Y., Anderson, C.A., Essers, J., Mitrovic, M., Ning, K., Cleynen, I., Theatre, E., Spain, S.L., Raychaudhuri, S., Goyette, P., Wei, Z., Abraham, C. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 2012; 491(7422): 119-24.
Duerr, R.H., Taylor, K.D., Brant, S.R., Rioux, J.D., Silverberg, M.S., Daly, M.J., Steinhart, A.H., Abraham, C., Regueiro, M., Griffiths, A., Dassopoulos, T., Bitton, A., Yang, H., Targan, S., Datta, L.W., Kistner, E.O., Schumm, L.P., Lee, A.T., Gregersen, P.K., Barmada, M.M. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science. 2006; 314(5804): 1461-3.
Silverberg, M.S., Duerr, R.H., Brant, S.R., Bromfield, G., Datta, L.W., Jani, N., Kane, S.V., Rotter, J.I., Schumm, P.L., Steinhart, H.A., Taylor, K.D., Yang, H., Cho, J.H., Rioux, J.D., Daly, M.J. Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease. European Journal of Human Genetics. 2007; 15(3): 328-35.
Barrett, J.C., Hansoul, S., Nicolae, D.L., Cho, J.H., Duerr, R.H., Rioux, J.D., Brant, S.R., Silverberg, M.S., Taylor, K.D., Barmada, M.M., Bitton, A., Dassopoulos, T., Datta, L.W., Green, T., Griffiths, A.M., Kistner, E.O., Murtha, M.T., Regueiro, M.D., Rotter, J.I., Schumm, L.P. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nature Genetics. 2008; 40(8): 955-62.
Anderson, C.A., Boucher, G., Lees, C.W., Franke, A., D'Amato, M., Taylor, K.D., Lee, J.C., Goyette, P., Imielinski, M., Latiano, A., Lagace, C., Scott, R., Amininejad, L., Bumpstead, S., Baidoo, L., Baldassano, R.N., Barclay, M., Bayless, T.M., Brand, S., Buning, C. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nature Genetics. 2011; 43(3): 246-52.
Adamik, J., Henkel, M., Ray, A., Auron, P.E., Duerr, R., Barrie, A. The IL17A and IL17F loci have divergent histone modifications and are differentially regulated by prostaglandin E2 in Th17 cells. Cytokine. 2013; 64(1): 404-12.
Cleynen, I., Boucher, G., Jostins, L., Schumm, L.P., Zeissig, S., Ahmad, T., Andersen, V., Andrews, J.M., Annese, V., Brand, S., Brant, S.R., Cho, J.H., Daly, M.J., Dubinsky, M., Duerr, R.H., Ferguson, L.R., Franke, A., Gearry, R.B., Goyette, P., Hakonarson, H. Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study. Lancet. 2016; 387(10014): 156-67.
Li, D., Achkar, J.P., Haritunians, T., Jacobs, J.P., Hui, K.Y., D'Amato, M., Brand, S., Radford-Smith, G., Halfvarson, J., Niess, J.H., Kugathasan, S., Buning, C., Schumm, L.P., Klei, L., Ananthakrishnan, A., Aumais, G., Baidoo, L., Dubinsky, M., Fiocchi, C., Glas, J. A pleiotropic missense variant in SLC39A8 is associated with Crohn's disease and human gut microbiome composition. Gastroenterology. 2016.
Sponsored Research/Activities
Title: IBD Plexus
Role: Co-Investigator
Funding Agency: Crohns & Colitis Foundation
Start Year: 2015
End Year: 2018
Title: Leadership Operations Center (LOC): Microbicide Trials Network MTN 026 Year 10 Protocol Funds
Role: Co-Investigator
Funding Agency: Magee Womens Research Institute and Foundation/National Institute of Allergy & Infectious Diseases
Grant Number: UM1 AI068633
Start Year: 2015
End Year: 2016
Title: Aids Clinical Trial Group: Protocol Funds
Role: Co-Investigator
Funding Agency: Brigham and Women's Hospital, Inc./National Institute of Allergy & Infectious Diseases
Grant Number: UM1 AI068636
Start Year: 2015
End Year: 2015
Title: Dipyridamole as a Modulator of HIV-1 Inflammation by Adenosine Regulation
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: U01 AI1110410
Start Year: 2014
End Year: 2017
Title: Integration and Transition Team
Role: Principal Investigator
Funding Agency: Crohns & Colitis Foundation
Start Year: 2014
End Year: 2015
Title: Phase 1 Assessment of TMC-278 LA
Role: Co-Investigator
Funding Agency: Magee Womens Hospital/Bill & Melinda Gates Foundation
Start Year: 2013
End Year: 2016
Title: Pitt-Ohio State - Georgetown Clinical Trials Unit
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: UM1 AI069494
Start Year: 2013
End Year: 2014
Title: NIDDK IBD Genetics Consortium Genetic Research Center
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: U01 DK062420
Start Year: 2012
End Year: 2017
Title: Identifying Gene Expression Traits for IBD-associated Th17 Pathway eQTL Analyses
Role: Principal Investigator
Funding Agency: Crohns & Colitis Foundation
Start Year: 2011
End Year: 2012
Title: Development of an IBD Genetics Research Program
Role: Co-Investigator
Funding Agency: Cleveland Clinic
Start Year: 2009
End Year: 2013
Title: Replication of Association Signals Identified in Ulcerative Colitis GWAS
Role: Principal Investigator
Funding Agency: National Cancer Institute
Grant Number: R01 CA141743
Start Year: 2009
End Year: 2013
Title: Replication of Association Signals Identified in Ulcerative Colitis GWAS
Role: Principal Investigator
Funding Agency: National Cancer Institute
Grant Number: R01 CA141743
Start Year: 2009
End Year: 2013
Title: NIDDK IBD Genetics Consortium Genetic Research Center
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: U01 DK062420
Start Year: 2007
End Year: 2012
Notable Achievements
CCFA IBD Plexus Associate Chief Scientist, Translational Research, 2015 - Present
CCFA IBD Plexus Integration and Transition Team Member, 2014 - 2015
Inflammatory Bowel Disease Genetic Research Chair, 2011 - Present
Ad Hoc member of Genetics of Health and Disease NIH Study Section and NIH Special Emphasis Panels, 2008, 2009, 2012, 2016
Member, American Society of Human Genetics, 2003 - Present
Principal Investigator of NIDDK IBD Genetic Consortium Genetic Research Center, 2002 - Present
Editor, Genetics Section, Inflammatory Bowel Diseases, 2002-2006, 2008 – 2011
Physician of the Year, Crohn’s & Colitis Foundation of America, Western Pennsylvania/West Virginia Chapter, 2000
Crohn’s & Colitis Foundation of America Grants Review Committee, 1996 -1999, 2009 - 2011
Member, American Gastroenterological Association, 1992 - Present