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Department of Medicine

Department of Medicine

  Division of Gastroenterology, Hepatology and Nutrition

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photo Kapil Brijmohan Chopra, MD

Professor of Medicine

Medical Director, Comprehensive Liver Program, UPMC Liver Pancreas Institute

Primary Physician, UPMC Liver Transplant Program, UNOS

Program Director, Transplant Hepatology Fellowship Program

Adjunct Appointment, Clinical and Translational Science, University of Pittsburgh, Institute of Clinical Research Education

Email: choprak@dom.pitt.edu

Phone: 412-647-4963

Contact
Office: Division of Gastroenterology, Hepatology & Nutrition Center for Liver Diseases
3471 Fifth Ave. 916 Kaufmann Bld.
Pittsburgh, PA 15213
 
Phone: 412-647-4963
Fax: 412-647-9268
E-mail: choprak@dom.pitt.edu
Administrative Assistant:
Cheronda Craig
Address: Division of Gastroenterology, Hepatology & Nutrition/ Center for Liver Diseases
3471 Fifth Ave 916 Kaufmann Bld.
Pittsburgh, PA 15213
Email: craigcs@upmc.edu
Phone: 412-647-5470
Fax: 412-647-5736
Administrative Assistant:
Cathy Freehling
Address: Division fo Gastroenterology, Hepatology & Nutrition, Center for Liver Diseases
3471 Fifth Ave. 916 Kaufmann Bld
Pittsburgh, PA 15213
Email: freehlingca@upmc.edu
Phone: 412-647-4963
Fax: 412-647-9268
Education and Training
Education
M.B.B.S., Grant Medical College, University of Bombay, India, 1988
M.D., Grant Medical College, University of Bombay, India, 1990
D.M., Topiwala National Medical College, University of Bombay, India, 1992
HSC, Jaihind College, Bombay, India, 1981
ICSE, St Mary’s School, Bombay, India, 1978
Training
Residency - Internal Medicine, Western Pennsylvania Hospital, Pittsburgh, PA, 1998
Fellowship - Gastroenterology & Hepatology, University of Pittsburgh Medical Center, Pittsburgh, PA, 2000
Clinical Research Fellow - Gastroenterology, Chelsea & Westminster Hospital; Charing Cross Hospital, London, United Kingdom, 1994
Fellowship - Gastroenterology, B.Y.L. Nair Ch. Hospital, University of Bombay, India, 1991
Residency - Internal Medicine, Sir J.J. Hospital, University of Bombay, India, 1987
Research Interest
Dr. Chopra is a Professor of Medicine whose research interests focus on the cholestatic liver diseases primary sclerosing cholangitis and primary biliary cirrhosis. He has been involved in collaborative research projects with the Starzl Transplant Institute and the Liver Cancer Center, and has served as co-investigator on a number of multicenter trials investigating novel therapies and approaches to the management of viral hepatitis. His research work has culminated in 50 scientific presentations at national and international conferences.

He was a co-investigator on the following NIH-funded research studies:

PSC Resource of Genetic Risk, Environment and Synergy Studies (PROGRESS) – Principal Investigator – Dr. K Lazaridis, Mayo Clinic College of Medicine.

A Preliminary Study of the Efficacy and Safety of Carbamazepine in Severe Liver Disease Due to Alpha-1-Antitrypsin Deficiency (Principal Investigator – Dr. David Perlmutter, Children’s Hospital, Pittsburgh)

A prospective study comparing surgical therapies versus interventional radiologic interventions for management of gastrointestinal bleeding in patients with chronic liver disease.

With respect to publications, Dr. Chopra has 26 publications in peer-reviewed journals with five articles as first author and ten as senior author. He has contributed as the senior author for four textbook chapters and has a monograph on Hepatic Steatosis on the British Medical Journal (BMJ) Point of Care project.

In recognition of his role as a mentor and his contributions to the Clinical Research Scholars Program (CRSP) of the Clinical and Translational Science Institute (CTSI), he was offered a secondary appointment in Clinical and Translational Science at the University of Pittsburgh in September 2012.
Clinical Interest
Dr. Chopra is based at the UPMC Center for Liver Diseases within the Division of Gastroenterology, Hepatology & Nutrition, the Starzl Transplant Institute and the Liver Pancreas Institute. He provides a consultative service in Hepatology and Transplant Hepatology at the UPMC Presbyterian/Montefiore Hospitals, UPMC Passavant Hospital, UPMC Shadyside Hospital and the UPMC Magee Women’s Hospital.

Dr. Chopra's clinical interests include the following: evaluation and management of patients with acute and chronic liver disease.
These include: abnormal liver function tests; acute liver failure; cirrhosis of the liver; viral hepatitis C; viral hepatitis B; alcoholic and nonalcoholic fatty liver disease; autoimmune hepatitis; primary biliary cirrhosis; primary sclerosing cholangitis; genetic liver disorders - hereditary hemochromatosis; alpha-one antitrypsin deficiency; liver tumors - both benign [hemangioma; adenoma; focal nodular hyperplasia] and malignant [hepatocellular carcinoma]; non cirrhotic portal hypertension - portal venous thrombosis.

Management of complications of cirrhosis of liver [portal hypertension - esophageal varices; gastric varices; ascites; hepatic encephalopathy].

He is board-certified in Transplant Hepatology - involved in the evaluation and selection of patients for liver transplantation; managing patients on the liver transplant waitlist; management of patients after liver transplantation.

He is board-certified in Gastroenterolgy who provides gastrointestinal endoscopy services [esophagogastroduodenoscopy; colonoscopy] to his patients.

Dr Chopra has served in several leadership/administrative roles throughout his clinical career.

He is currently the Medical Director of the Comprehensive Liver Program, UPMC Liver Pancreas Institute [since 2006]; Primary Physician, UPMC Liver Transplantation Program - UNOS [since 2009].

Prior leadership/administrative roles include: Clinical Director of Hepatology; Medical Director - Liver Transplantation; Director - Hemochromatosis Program.
Educational Interest
Dr. Chopra plays an active role in teaching medical students, internal medicine residents and gastroenterology and hepatology fellows. Besides precepting them in outpatient and inpatient settings, he is involved in the training and precepting of gastroenterology fellows with respect to GI endoscopic procedures and hepatology education.

He is a faculty lecturer for the second year medical school course in Digestion and Nutrition at the University of Pittsburgh Medical School and has served as a facilitator of problem based learning (PBL) sessions for this course (1998-2005; 2006-2013) as well as for the clinical workshops related to liver diseases. He is also a contributor to the syllabus for this course.

He is also a faculty lecturer for the Gastroenterology and Hepatology core curriculum lecture series for internal medicine residents and the Gastroenterology State of the Art lecture series for gastroenterology faculty and fellows. He served as coordinator for the Gastroenterology fellows journal club meetings for a period of one year (2000-2001). Additionally, he was a faculty lecturer for the “Acute Management Series” for the Internal Medicine residents each year from 2006 to 2013.

Dr. Chopra plays an active role in educating physicians, mid-level providers [nurse practitioners; physician assistants, nurses] through continuing medical education (CME) conferences both at the University and at the community level. He has served as the keynote speaker or visiting professor in over 30 CME symposia and conferences since 2000.

He is currently the Program Director, UPMC Transplant Hepatology Fellowship Program [since 2006]

He was the Program Director, Transplant Hepatology Fellowship Program, Mayo Clinic Arizona [2005-2006].
Publications
For my complete bibliography, Click Here.
Selected Publications:
Yang ZJ1, Sheth SH, Smith CH, Schmotzer AR, Lippello AL, Al-Khafaji A, Chopra KB, Smith RE. Plasma from chronic liver disease subjects exhibit differential ability to generate thrombin. Blood Coagul Fibrinolysis. 2015; 7: 844-7.
Eaton JE, Juran BD, Atkinson EJ, Schlicht EM, Xie X, de Andrade M, Lammert CS, Luketic VA, Odin JA, Koteish AA, Kowdley KV, Chopra KB, Hirschfield GM, Chalasani NP, Lazaridis KN. A comprehensive assessment of environmental exposures among 1000 North American patients with primary sclerosing cholangitis, with and without inflammatory bowel disease. Aliment Pharmacol Ther. 2015; 10: 980-90.
Reddy SK, Marsh JW, Varley PR, Mock BK, Chopra KB, Geller DA, Tsung A. Underlying steatohepatitis, but not simple hepatic steatosis, increases morbidity after liver resection: A case-control study. Hepatology. 2012; 56: 2221-30.
Patel D, Singh P, Katz W, Hughes C, Chopra K, Nemec J. QT interval prolongation in end-stage liver disease cannot be explained by nonhepatic factors. Ann Noninvasive Electrocardiol. 2014; 6: 574-81.
Guo L, Orrego M, Rodriguez-Luna H, Balan V, Byrne T, Chopra K, Douglas D, Harrison E, Moss A, Reddy KS, Williams J, Rakela J, Mulligan D, Vargas H. Living Donor Liver Transplantation for Hepatitis C-Related Cirrhosis: No difference in histological recurrence when compared to deceased donor liver transplantation recipients. Liver Transplantation. 2006; 12: 560--5.
Vlavianos P, Chopra K, Mandalia S, Anderson M, Thompson J,, Westaby D. Endoscopic balloon dilatation versus endoscopic sphincterotomy for the removal of bile duct stones: a prospective randomized trial. Gut. 2003; 52: 1165-9.
Chopra KB, Peters RA, O'Toole PA, Williams SGJ, Gimson AES, Lombard MG, Westaby D. Randomised study of endoscopic biliary endoprosthesis versus duct clearance for bile duct stones in high risk patients. Lancet. 1996; 348: 791-3.
Gilson RJC, Chopra KB, Newell AM, Murray-Lyon IM, Nelson MR, Rice S, Tedder RS, Toole J, Jaffe HS, Weller IVD. A placebo-controlled phase I/II study of adefovir dipivoxil in patients with chronic hepatitis B virus infection. Journal of Viral Hepatitis. 1999; 6: 387-95.
Chopra KB, Demetris AJ, Blakolmer K, Dvorchik I, Laskus T, Wang LF, Arraya VR, Dodson F, Fung J J, Rakela J, Vargas, HE. Progression of liver fibrosis in patients with chronic hepatitis C after orthotopic liver transplantation. Transplantation. 2003; 76: 1487-91.
Chu AS, Chopra KB, Perlmutter DH. Is Severe Progressive Liver Disease Caused by Alpha-1-Antitrypsin Deficiency More Common in Children or Adults?. Liver Transplantation. 2016; 22: 886-894.
Sponsored Research/Activities
Title: Genomics of Primary Biliary Cirrhosis
Role: Co-Investigator
Funding Agency: Mayo Foundation/National Institute of Health
Grant Number: R01 DK080670
Start Year: 2013
End Year: 2015
Title: Carbamazepine for Severe Liver Disease Due to Antitrypsin Deficiency
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R21 DK092567
Start Year: 2011
End Year: 2014
Title: PSC Resource of Genetic Risk, Environment & Synergy Studies (PROGRESS)
Role: Co-Investigator
Funding Agency: Mayo Foundation/National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK84960
Start Year: 2010
End Year: 2015
Notable Achievements
Community Liver Alliance (CLA) - You Make a Difference Award, 2016
The American Liver Foundation (ALF) - Tribute to Excellence Award, 2008
Pennsylvania Department of Health Viral Hepatitis Award of Excellence, 2008
Outstanding Resident Award, Medical Residency Program, Western Pennsylvania Hospital, 1998
Outstanding Resident Award, Medical Residency Program, Western Pennsylvania Hospital, 1997
Inlaks Foundation Fellowship - Gastrointestinal Endoscopy, 1994
University of Bombay Merit Scholarship, Internal Medicine, M.D, 1988
Glaxo Medical Education Award for Best Student (Medicine), Grant Medical College, 1988
J.J. Hospital and Grant Medical College Research Society Prize, M.B.,B.S., 1988
University of Bombay Charles Morehead Prize, Clinical Medicine including Pediatrics, M.B.,B.S, 1988