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Department of Medicine

Department of Medicine

  Division of Gastroenterology, Hepatology and Nutrition

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photo Randall E. Brand, MD

Academic Director, GI-Division, UPMC Shadyside

Director, GI Malignancy Early Detection, Diagnosis & Prevention Program

Email: brandre@upmc.edu

Phone: 412-623-3105

Contact
Office: Division of Gastroenterology, Hepatology & Nutrition @ Shadyside
5200 Centre Avenue, Suite 409
Pittsburgh, PA 15232
 
Phone: 412-623-3105
Fax: 412-623-3106
E-mail: brandre@upmc.edu
Administrative Assistant:
Nancy Glessman
Address: Division of Gastroenterology, Hepatology & Nutriti
5200 Centre Avenue, Suite 409
Pittsburgh, PA 15232
Phone: 412-623-3105
Fax: 412-623-3106
Education and Training
Education
MD, University of Michigan / Ann Arbor, 1987
BS, University of Michigan / Ann Arbor, 1983
Training
Gastroenterology Fellowship - Clinical Track, University of California / San Francisco, 1993
Residency - Internal Medicine, University of Michigan / Ann Arbor, 1990
Internship - Internal Medicine, University of Michigan / Ann Arbor, 1988
Research Interest
Dr. Brand is a Professor of Medicine and a physician-scientist with an extensive background in pancreatic diseases mainly focused on the early diagnosis of pancreatic cancer and cystic lesions of the pancreas. He also has research interests involving familial pancreatic cancer and other hereditary GI disorders. He is leader of the University of Pittsburgh’s Pancreatic Adenocarcinoma Gene-Environment Registry (PAGER). The biospecimen repository developed as part of the PAGER study is nationally recognized and serves as an excellent resource for multiple NIH/NCI funded projects along with national and international collaborations with outside researchers. He is a key contributor to the Early Detection Research Network, especially in research related to pancreatic cancer and cystic neoplasms and is currently funded in the network as a principal investigator to lead both a multi-center Pancreatic Cancer Clinical Validation Center and Biomarker Developmental Laboratory.
Clinical Interest
Dr. Brand's clinical practice focuses on the management of pancreatic cancer, cystic lesions of the pancreas and patients with other gastrointestinal (GI) cancers. As director of the Hereditary GI Tumor Program, Dr. Brand specializes in the management of individuals at high risk for the development of colon cancer,pancreatic cancer and other GI malignancies. Dr. Brand works closely with Genetic counselors who have an expertise in the evaluation individuals with a GI cancer predisposition based on personal and family history.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Lynch, H.T., Brand, R.E., Lynch, J.F., Fusaro, R.M., Kern, S.E. Hereditary factors in pancreatic cancer. Journal of hepato-biliary-pancreatic surgery. 2002; 9(1): 12-31.
Lynch, H.T, Deters, C.A, Lynch, J.F, Brand, R.E. Familial pancreatic carcinoma in Jews. Familial Cancer. 2004; 3(3-4): 233-40.
Lynch, H.T., Deters, C.A., Synder, C.L., Lynch, J.F., Villeneuve, P., Silberstein, J., Martin, H., Narod, S.A., Brand, R.E. BRCA1 and pancreatic cancer: pedigree findings and their causal relationships. Cancer genetics and cytogenetics. 2005; 158(2): 119-25.
Brand, R.E., Lynch, H.T. Genotype/phenotype of familial pancreatic cancer. Endocrinology and metabolism clinics of North America. 2006; 35(2): 405-15.
Uttam, S., Bista, R.K., Staton, K., Alexandrove, S., Choi, S., Bakkenist, C.J., Hartman, D.J., Brand, R.E., Liu, Y. Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation. Biomedical optics express. 2013; 4(4): 596-613.
Brand, H., Diergaarde, B., O'Connell M.R., Whitcomb, D.C., Brand, R.E. Variation in the y-glutamyltransferase 1 gene and risk of chronic pancreatitis. Pancreas. 2013; 42(5): 836-40.
Stan, S.D., Singh, S.V., Whitcomb, D.C., Brand, R.E. Phenethyl isothiocyanate inhibits proliferation and induces apoptosis in pancreatic cancer cells in vitro and in a MIAPaca2 xenograft animal model. Nutrition and cancer. 2014; 66(4): 747-55.
Hartman, D.J., Krasinskas, A.M., Uttam, S., Staton, K., Bista, R., Rizvi, S., Slivka, A., Brand, R., Liu, Y. Assessment of nuclear nanomorphology marker to improve the detection of malignancy from bile duct biopsy specimens. American journal of clinical pathology. 2014; 141(6): 884-91.
Brand, R.E. Decade in review-pancreatic diseases: advances in understanding and care of pancreatic diseases. Nature reviews. Gastroenterology & hepatology. 2014; 11(11): 650-2.
Wilcox, C.M., Yadav, D., Ye, T., Gardner T.B., Gelrud, A., Sandhu, B.S., Lewis, M.D., Al-Kaade S., Cote, G.A., Forsmark, C.E., Guda, N.M., Conwell, D.L., Banks, P.A., Muniraj, T., Romagnuolo, J., Brand, R.E., Slivka, A., Sherman, S., Wisniewski, S.R., Whitcomb, D.C. Chronic pancreatitis pain pattern and severity are independent of abdominal imaging findings. Clinical gastroenterology and hepatology: the official clinical practice journal. 2015; 13(3): 552-60.
Sponsored Research/Activities
Title: Consortium for the Study of Pancreatitis: Pittsburgh Clinical Center
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: U01 DK108306
Start Year: 2015
End Year: 2020
Title: Employing Pharmacology in Human Disease Relevant Tissue to Support Pharmaceutical Discovery in Inflammatory Bowel Disease
Role: Co-Investigator
Funding Agency: Janssen Pharm
Start Year: 2014
End Year: 2016
Title: Novel Nanoscale Single-Cell Analysis of Exfoliative Cytology
Role: Co-Investigator
Funding Agency: National Institute of Biomedical Imaging and Bioengineering
Grant Number: R01 EB016657
Start Year: 2013
End Year: 2017
Title: Phase 1 Assessment of TMC-278 LA
Role: Co-Investigator
Funding Agency: Magee Womens Hospital/Bill & Melinda Gates Foundation
Start Year: 2013
End Year: 2016
Title: Detection of Early Pancreatic Neoplasia - Vogelstein
Role: Principal Investigator
Funding Agency: Lustgarten Foundation
Start Year: 2013
End Year: 2016
Title: Microbicide Safety and Acceptability in Young Men
Role: Co-Investigator
Funding Agency: Magee Womens Hospital/National Institute of Child Health & Human Development
Grant Number: R01 HD059533
Start Year: 2011
End Year: 2014
Title: Aptamer Microbicide Development Program (MDP)
Role: Co-Investigator
Funding Agency: Magee Womens Hospital/University of California Los Angeles
Grant Number: U19 AI06014
Start Year: 2011
End Year: 2012
Title: Utility of the Two-MicroRNA (miRNA) qRT-PCR Assay in Assessment of Suspicious, Atypical, and Indeterminate Pancreatic Tissue Specimens
Role: Principal Investigator
Funding Agency: Asuragen, Inc.
Grant Number: DRUG
Start Year: 2010
End Year: 2012
Title: Slaptamer-Based Array Technology for Discovery of Pancreatic Cancer Plasma Biomarkers
Role: Principal Investigator
Funding Agency: SomaLogic
Grant Number: DRUG
Start Year: 2009
End Year: 2015
Notable Achievements
Named to “Pittsburgh Magazine Top Doctors”, Pittsburgh Magazine, 2012-2016
Named to “Best Doctors” for specialty in Gastroenterology, Best Doctors, Inc., 2010-2016
Recipient of the First Annual Moore Memorial Award for Pancreatic Cancer Research, National Hirschberg Foundation, 2011