SCHOOL OF MEDICINE  |  PITT HOME  |  FIND PEOPLE  |  FIND A DOCTOR AT UPMC

Department of Medicine

Department of Medicine

  Division of Gastroenterology, Hepatology and Nutrition

[Return To Index page]
photo David G. Binion, MD

Co-Director, IBD Center - Translational Research

Director, Nutrition Support Service

Email: biniond@upmc.edu

Phone: 412-864-7091

Contact
Office: Division of Gastroenterology, Hepatology and Nutrition
UPMC Presbyterian Hospital M2, C Wing - 200 Lothrop St.
Pittsburgh, PA 15213
 
Phone: 412-864-7091
Fax: 412-648-9378
E-mail: biniond@upmc.edu
Administrative Assistant:
Deborah Cadman
Address: Division of Gastroenterology, Hepatology & Nut
UPMC Presbyterian Hospital, M2, C Wing - 200 Lothrop St.
Pittsburgh, PA 15213
Email: cadmandj@upmc.edu
Phone: 412-647-4194
Fax: 412-648-9378
Administrative Assistant:
Teresa McFerron
Address: Division of Gastroenterology, Hepatology & Nut
UPMC Presbyterian Hospital, M2, C Wing - 200 Lothrop St.
Pittsburgh, PA 15213
Email: hutchiso@pitt.edu
Phone: 412-383-6968
Fax: 412-648-9731
Education and Training
Education
AB - General Studies, Harvard College - Cambridge, MA, 1984
MD, State Univ. of New York at Buffalo - Buffalo, NY, 1988
Training
Research Fellow - Immunology, Cleveland Clinic Fdn. Research Inst. - Cleveland, OH, 1993
Internship & Residency, Rhode Island Hospital (Brown Univ.) - Providence, RI, 1991
Gastroenterology Fellowship, Univ. Hospitals of Cleveland (Case Western) - Cleveland, OH, 1993
Research Interest
Dr. David Binion is a Professor of Medicine and inflammatory bowel disease (IBD) investigator whose career has focused on defining the cellular and molecular mechanisms underlying human chronic gut inflammation and the translation of this knowledge into improved care for patients suffering from Crohn’s disease and ulcerative colitis. Current work has centered on Big Data analytics and the development and transformation of the UPMC IBD Registry, a prospective, multi-year, longitudinal natural history registry database of >3,000 consented IBD patients into a metadata platform for scientific discovery. Working in collaboration with computer scientists from the University of Pittsburgh School of Information Science, this relational database continuously curates and transforms observational clinical information from the electronic medical record (EMR) and maintains >10,000 person-years of associated metadata in a secure data warehouse. Areas of active investigation include:
• Developing prognostic biomarkers of IBD severity.
• Characterizing the impact of diet and nutrition on IBD natural history.
• Identification of biomarker patterns to predict development of dysplasia/cancer in IBD.
• Identification of predictive biomarkers to guide therapeutic selection in IBD.
• Comparative effectiveness studies in IBD maintenance therapy.
• Defining the impact of surgical anastomotic technique on longterm clinical outcomes in Crohn’s disease.
• Use of healthcare charge data as a comprehensive phenotype.
• Defining the impact of Clostridium difficile infection on IBD natural history.
• Characterizing extra-intestinal manifestations including anemia and autonomic dysfunction on the natural history of IBD.
• Developing clinical decision support tools to optimize IBD care and implement precision medicine.
Clinical Interest
Inflammatory bowel disease.
Nutrition support.
Intestinal transplantation.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Regueiro, M., Kip, K.E., Schraut, W., Baidoo, L., Sepulveda, A.R., Pesci, M., El-Hachem, S., Harrison, J., Binion, D. Crohn's disease activity index does not correlate with endoscopic recurrence one year after ileocolonic resection. Inflammatory Bowel Diseases. 2011; 17(1): 118-26.
Barrie, A., Mourabet, M.E., Weyant, K., Clarke, K., Gajendran, M., Rivers, C., Park, S.Y., Hartman, D., Saul, M., Regueiro, M., Yadav, D., Binion, D.G. Recurrent blood eosinophilia in ulcerative colitis is associated with severe disease and primary sclerosing cholangitis. Digestive Diseases and Sciences. 2013; 58(1): 222-8.
Ramos-Rivers, C., Regueiro, M., Vargas, E.J., Szigethy, E., Schoen, R.E., Dunn, M., Watson, A.R., Schwartz, M., Swoger, J., Baidoo, L., Barrie, A., Dudekula, A., Youk, A.O., Binion, D.G. Association between telephone activity and features of patients with inflammatory bowel disease. Clinical Gastroenterology and Hepatology. 2014; 12(6): 986-94.
Koutroubakis, I.E., Regueiro, M., Schoen, R.E., Ramos-Rivers, C., Hashash, J.G., Schwartz, M., Swoger, J., Barrie, A., Baidoo, L., Dunn, M.A., Hartman, D., Binion, D.G. Multiyear Patterns of Serum Inflammatory Biomarkers and Risk of Colorectal Neoplasia in Patients with Ulcerative Colitis. Inflammatory Bowel Diseases. 2016; 22(1): 100-5.
Bhagya Rao, B., Koutroubakis, I.E., Ramos Rivers, C., Colombel, J.F., Regueiro, M., Swoger, J., Schwartz, M., Baidoo, L., Hashash, J., Barrie, A., Dunn, M.A., Binion, D.G. Delineation of Crohn's Disease Trajectories Using Change in Lemann Index: A Natural History Study. Journal of Clinical Gastroenterology. 2016; 50(6): 476-82.
Kabbani, T.A., Koutroubakis, I.E., Schoen, R.E., Ramos-Rivers, C., Shah, N., Swoger, J., Regueiro, M., Barrie, A., Schwartz, M., Hashash, J.G., Baidoo, L., Dunn, M.A., Binion, D.G. Association of Vitamin D Level with Clinical Status in Inflammatory Bowel Disease: A 5-Year Longitudinal Study. The American Journal of Gastroenterology. 2016; 111(5): 712-9.
Jiang, J., Click, B., Anderson, A.M., Koutroubakis, I.E., Rivers, C.R., Hashash, J.G., Dunn, M.A., Schwartz, M., Swoger, J., Barrie, A., Regueiro, M., Chang, C.C., Binion, D.G. Group-based Trajectory Modeling of Healthcare Financial Charges in Inflammatory Bowel Disease: A Comprehensive Phenotype. Clinical and Translational Gastroenterology. 2016; 7(7): e181.
Sponsored Research/Activities
Title: Natural History of Clostridium Difficile Infection in Inflammatory Bowel Disease Patients
Role: Principal Investigator
Funding Agency: Cubist Pharmaceuticals
Start Year: 2015
End Year: 2016
Title: Predictors of Treatment Outcomes for Crohns Disease
Role: Principal Investigator
Funding Agency: UCB, Inc.
Start Year: 2015
End Year: 2016
Title: Acute Pancreatitis as a Model to Predict Transition of Systemic Inflammation to Organ Failure in Trauma and Critical Illness
Role: Co-Investigator
Funding Agency: Department of Defense
Start Year: 2014
End Year: 2017
Title: Reinforcement-Enhancing Effects of NRT
Role: Co-Investigator
Funding Agency: National Agency for Drug Abuse
Grant Number: R01 DA035774
Start Year: 2014
End Year: 2017
Title: Employing Pharmacology in Human Disease Relevant Tissue to Support Pharmaceutical Discovery in Inflammatory Bowel Disease
Role: Co-Investigator
Funding Agency: Janssen Pharm
Start Year: 2014
End Year: 2016
Title: Mean SIBDQ to Stratify Crohn's Disease Patients: Impact of Neuropsychiatric Illness, Chronic Pain and Refractory Inflammation
Role: Principal Investigator
Funding Agency: Janssen Pharm
Grant Number: DRUG
Start Year: 2013
End Year: 2016
Notable Achievements
Fellow, American Gastroenterological Association, 2007
Pittsburgh's Best Doctors, 2016