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Department of Medicine

Department of Medicine

  Division of Endocrinology and Metabolism

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(412) 648-9770


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Postdoctoral Associates


Daniel Harmon, PhD

Phone: 412-648-9770
Email: harmond@pitt.edu
Office: BST W1026-4A

 


EDUCATION AND TRAINING:

Education: BS (Rice University), PhD (University of Virginia)
Training: My graduate work in Coleen McNamara's lab at the University of Virginia focused on understanding the role adipose tissue B cells play in obesity-associated inflammation. My research helped identify a unique subset of IgM-producing B1 B cells as important mediators of obesity-associated adipose tissue inflammation and insulin resistance. In addition, results from my project revealed the presence of a recently-described B1 B cell within human omental adipose tissue. I also collaborated on projects that identified important roles for B1 and B2 B cells in atherosclerosis and experimentally-induced abdominal aortic aneurysms, respectively.

RESEARCH INTEREST: I am interested in understanding how crosstalk between metabolic parameters and the immune system impact human disease. In the liver, chronic, low-grade inflammation is thought to disrupt metabolic signaling and contribute to co-morbidities associated with obesity. However, the signals that regulate immune cell recruitment to the liver, as well as functional roles for immune cell subsets within the liver, are poorly understood in the context of obesity.  My projects in the O'Doherty lab include 1) identifying the role free fatty acids play in initiating hepatic inflammation and 2) characterizing the functional activity of dendritic cells that infiltrate the liver during obesity progression.

SELECTED PUBLICATION:
Harmon DB, Srikakulapu P, Kaplan JL, Oldham SN, McSkimming C, Garmey J, Perry HM, Kirby JL, Prohaska TA, Gonen A, Hallowell P, Schirmer B, Tsimikas S, Taylor AM, Witztum JL, McNamara CA. Protective role for B-1b B cells and IgM in obesity-associated inflammation, glucose intolerance, and insulin resistance. Arterioscler Thromb Vasc Biol. 36(4):682-691, 2016. (PMID: 26868208 PMCID: PMC4808436

 

 

Krystle Frahm, PhD

Phone: 412-648-9770
Email: kaf130@pitt.edu

 


EDUCATION AND TRAINING:

Education:
BA, Texas State University, 2005
MA, Texas State University
PhD, Colorado State University, 2014

Training:
Postdoctoral Scholar, University of Pittsburgh, current

RESEARCH INTEREST: Central regulation of feeding behavior, hypothalamic development, sex differences, developmental neurobiology,

SELECTED PUBLICATION:
Frahm KA, Waldman JK, Luthra S, Rudine AC, Monaghan-Nichols AP, Chandran UR, DeFranco DB. A comparison of the sexually dimorphic dexamethasone transcriptome in mouse cerebral cortical and hypothalamic embryonic neural stem cells. Mol Cell Endocrinol. 2017 May 26. pii: S0303-7207(17)30295-2. doi: 10.1016/j.mce.2017.05.026. [Epub ahead of print]. PMID: 28554804.

Frahm KA*, Peffer ME*, Zhang JY, Luthra S, Chakka AB, Couger MB, Chandran UR, Monaghan-Nichols AP, DeFranco DB. The dexamethasone transcriptome in hypothalamic embryonic neural stem cells. Mol Endocrinol. 2016 Jan;30(1):144-54. doi: 10.1210/me.2015-1258. Epub 2015 Nov 25. PMCID: PMC4695633.

Frahm KA, Tobet SA. Development of the blood-brain barrier within the paraventricular nucleus of the hypothalamus: influence of fetal glucocorticoid excess. Brain Struct Funct. 2015 Jul;220(4):2225-34. doi: 10.1007/s00429-014-0787-8. Epub 2014 May 11. PMCID: PMC4481307.

SOCIETY MEMBERSHIPS:
Society for Neuroscience, The Endocrine Society, National Postdoctoral Association, Society of Ingestive Behaviors, The Obesity Society, American Diabetes Association

HONORS:
Journal of Molecular Endocrinology Author Feature (2016)
University of Pittsburgh Postdoctoral Association Data & Dine Travel Award (2016)
NIH Loan Repayment Ambassador (2016 – current)
Highest Honors & Best Overall - Colorado State University Cell & Molecular Biology Annual Graduate Poster Symposium (2014)
Endocrine Society Early Career Forum Travel Award (2014 & 2015)
Endocrine Society Outstanding Abstract Award (2013)
US - South American Workshop in Neuroendocrinology Young Investigator Travel Award (2011 & 2013)
Thornburg Graduate Research Excellence Award (2012)

FUNDING:
American Diabetes Association Postdoctoral Fellowship Award (2017 – current)
NIH Loan Repayment Grant (2015 – 2017)
NIH T32 Training Program in Endocrinology, Diabetes, and Metabolism Fellowship (2014 -2017)
NIH F31 NRSA Fellowship (2013-2014)
National Science Foundation GK-12 Fellowship (2010 – 2012)

National Science Foundation Bridge to the Doctorate Fellowship (2008 – 2010)