Department of Medicine

University of Pittsburgh

Division of Endocrinology and Metabolism
200 Lothrop Street
E1140 BST
Pittsburgh, PA 15213
Administrative/Research Office: (412) 648-9770
Patient/Clinical Inquiries: (412) 586-9700

Vladimir Ritov, PhD
photo

Associate Professor of Medicine
Office: N810 Montefiore Hospital
3457 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-692-2281
Fax: 412-692-2165
E-mail: ritov@pitt.edu
Education
MS, Moscow State University, Russia, 1968
PhD, Moscow State University, Russia, 1971
Training
Postdoctoral Fellowship, Moscow State University, Russia, 1973
Area of Specialization/Research Interest  
Effects of diabetes & obesity - glycolytic enzymes
Effects of diabetes & obesity-oxidative enzymes
Effects of weight loss and exercise
Effect of exercise-mitochondrial electron transpor
Lipid metabolism in diabetes and obesity
Generation of reactive oxygen species by mitochond
 
Recent Peer-Reviewed Publications
Title: Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity
Author(s): Ritov VB, Menshikova EV, Azuma K, Wood R, Toledo FG, Goodpaster BH, Ruderman NB, Kelley DE
Year: 2010
Journal: Am J Physiol Endocrinol Metab
Volume: 298(1)
Page(s): 49-58
Title: Oxidative lipidomics of apoptosis: quantitative assessment of phospholipid hydroperoxides in cells and tissues
Author(s): Tyurin VA, Tyurina YY, Ritov VB, Lysytsya A, Amoscato AA, Kochanek PM, Hamilton R, Dekosky ST, Greenberger JS, Bayir H, Kagan VE
Year: 2010
Journal: Methods Mol Biol
Volume: 610
Page(s): 353-74
Title: Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content
Author(s): Toledo FG, Menshikova EV, Azuma K, Radiková Z, Kelley CA, Ritov VB, Kelley DE
Year: 2008
Journal: Diabetes
Volume: 57(4)
Page(s): 987-94
Title: Characteristics of skeletal muscle mitochondrial biogenesis induced by moderate-intensity exercise and weight loss in obesity
Author(s): Menshikova EV, Ritov VB, Ferrell RE, Azuma K, Goodpaster BH, Kelley DE
Year: 2007
Journal: J Appl Physiol
Volume: 103(1)
Page(s): 21-7
Title: Cardiolipin switch in mitochondria: shutting off the reduction of cytochrome c and turning on the peroxidase activity
Author(s): Basova LV, Kurnikov IV, Wang L, Ritov VB, Belikova NA, Vlasova II, Pacheco AA, Winnica DE, Peterson J, Bayir H, Waldeck DH, Kagan VE
Year: 2007
Journal: Biochemistry
Volume: 46(11)
Page(s): 3423-34
Title: Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes
Author(s): Toledo FG, Menshikova EV, Ritov VB, Azuma K, Radikova Z, DeLany J, Kelley DE
Year: 2007
Journal: Diabetes
Volume: 56(8)
Page(s): 2142-7
Title: Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome
Author(s): Ruderman NB, Keller C, Richard AM, Saha AK, Luo Z, Xiang X, Giralt M, Ritov VB, Menshikova EV, Kelley DE, Hidalgo J, Pedersen BK, Kelly M
Year: 2006
Journal: Diabetes
Volume: 55 Suppl 2
Page(s): 48-54
Title: Effects of exercise on mitochondrial content and function in aging human skeletal muscle
Author(s): Menshikova EV, Ritov VB, Fairfull L, Ferrell RE, Kelley DE, Goodpaster BH
Year: 2006
Journal: J Gerontol A Biol Sci Med Sci
Volume: 61(6)
Page(s): 534-40
Title: Analysis of cardiolipin in human muscle biopsy
Author(s): Ritov VB, Menshikova EV, Kelley DE
Year: 2006
Journal: J Chromatogr B Analyt Technol Biomed Life Sci
Volume: 831(1-2)
Page(s): 63-71
Title: Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors
Author(s): Kagan VE, Tyurin VA, Jiang J, Tyurina YY, Ritov VB, Amoscato AA, Osipov AN, Belikova NA, Kapralov AA, Kini V, Vlasova II, Zhao Q, Zou M, Di P, Svistunenko DA, Kurnikov IV, Borisenko GG
Year: 2005
Journal: Nat Chem Biol
Volume: 1(4)
Page(s): 223-32