Department of Medicine

University of Pittsburgh

Division of Endocrinology and Metabolism
200 Lothrop Street
E1140 BST
Pittsburgh, PA 15213

Administrative/Research Office:
(412) 648-9770

Patient/Clinical Inquiries:
(412) 586-9700

John Dube, PhD


Instructor of Medicine

Office: Montefiore University Hospital, N807
3459 Fifth Avenue
Pittsburgh, PA 15213
Phone: 412-692-2257
Fax: 412-692-2165

BS, Shenandoah University, Winchester, VA, 1995
MS, James Madison University, Harrisonburg, VA, 1997
PhD, University of Pittsburgh, 2005

Postdoctoral Fellowship, Endocrinology, University of Pittsburgh, 2009

Area of Specialization/Research Interest  
Human skeletal muscle lipid accumulation and its link to insulin resistance

Recent Peer-Reviewed Publications
Title: Effects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance`
Author(s): Dubé JJ, Coen PM, DiStefano G, Chacon AC, Helbling NL, Desimone ME, Stefanovic-Racic M, Hames KC, Despines AA, Toledo FG, Goodpaster BH
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: Racial Differences in Peripheral Insulin Sensitivity And Mitochondrial Capacity In the Absence of Obesity
Author(s): DeLany JP, Dubé JJ, Standley RA, Distefano G, Goodpaster BH, Stefanovic-Racic M, Coen PM, Toledo FG
Year: 2014
Journal: J Clin Endocrinol Metab
Volume: 8
Title: Skeletal muscle as a regulator of the longevity protein, Klotho
Author(s): Avin KG, Coen PM, Huang W, Stolz DB, Sowa GA, Dubé JJ, Goodpaster BH, O'Doherty RM, Ambrosio F
Year: 2014
Journal: Front Physiol
Volume: 17
Page(s): 189
Title: Effect of a sustained reduction in plasma free fatty acid concentration on insulin signaling and inflammation in skeletal muscle from human subjects
Author(s): Liang H, Tantiwong P, Sriwijitkamol A, Shanmugasundaram K, Mohan S, Espinoza S, Dubé JJ, Defronzo RA, Musi N
Year: 2013
Journal: J Physiol
Volume: 591(pt11)
Page(s): 2897-909
Title: Reduced skeletal muscle oxidative capacity and elevated ceramide but not diacylglycerol content in severe obesity
Author(s): Coen PM, Hames KC, Leachman EM, Delany JP, Ritov VB, Menshikova EV, Dubé JJ, Toledo FG, Stefanovic-Racic M, Goodpaster BH
Year: 2013
Journal: Obesity (Silver Spring, Md)
Title: Lower thigh subcutaneous and higher visceral abdominal adipose tissue content both contribute to insulin resistance
Author(s): Amati F, Pennant M, Azuma K, Dubé JJ, Toledo FG, Rossi AP, Kelley DE, Goodpaster BH
Year: 2012
Journal: Obesity (Silver Spring, Md)
Volume: 20 (5)
Page(s): 1115-7
Title: DHA reduces the atrophy-associated Fn14 protein in differentiated myotubes during coculture with macrophages
Author(s): Finlin BS, Varma V, Nolen GT, Dubé JJ, Starnes CP, Rasouli N, Kern PA, Peterson CA
Year: 2012
Journal: J Nutr Biochem
Volume: 23(8)
Page(s): 885-91
Title: Exercise dose and insulin sensitivity: relevance for diabetes prevention
Author(s): Dubé JJ, Allison KF, Rousson V, Goodpaster BH, Amati F
Year: 2012
Journal: Med Sci Sports Exerc
Volume: 44 (5)
Page(s): 793-9
Title: Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide
Author(s): Dubé JJ, Amati F, Toledo FG, Stefanovic-Racic M, Rossi A, Coen PM, Goodpaster BH
Year: 2011
Journal: Diabetologia
Volume: 54 (5)
Page(s): 1147-56
Title: Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?
Author(s): Amati F, Dubé JJ, Alvarez-Carnero E, Edreira MM, Chomentowski P, Coen PM, Switzer GE, Bickel PE, Stefanovic-Racic M, Toledo FG, Goodpaster BH
Year: 2011
Journal: Diabetes
Volume: 60 (10)
Page(s): 2588-97
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