Department of Medicine

University of Pittsburgh

Division of Endocrinology and Metabolism
200 Lothrop Street
E1140 BST
Pittsburgh, PA 15213
Administrative/Research Office: (412) 648-9770
Patient/Clinical Inquiries: (412) 586-9700

John Dube, PhD

photo

Instructor of Medicine

Office: Montefiore University Hospital, N807
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-692-2257
Fax: 412-692-2165
E-mail: jjd8@pitt.edu

Education
BS, Shenandoah University, Winchester, VA, 1995
MS, James Madison University, Harrisonburg, VA, 1997
PhD, University of Pittsburgh, 2005

Training
Postdoctoral Fellowship, Endocrinology, University of Pittsburgh, 2009

Area of Specialization/Research Interest  
Human skeletal muscle lipid accumulation and its link to insulin resistance
 

Recent Peer-Reviewed Publications
Title: Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance
Author(s): Huang W, Metlakunta A, Dedousis N, Zhang P, Sipula I, Dube JJ, Scott DK, O'Doherty RM
Year: 2010
Journal: Diabetes
Volume: 59(2)
Page(s): 347-57
Title: Insulin resistance is associated with higher intramyocellular triglycerides in type I but not type II myocytes concomitant with higher ceramide content
Author(s): Coen PM, Dubé JJ, Amati F, Stefanovic-Racic M, Ferrell RE, Toledo FG, Goodpaster BH
Year: 2010
Journal: Diabetes
Volume: 59(1)
Page(s): 80-8
Title: Novel proapoptotic effect of hepatocyte growth factor: synergy with palmitate to cause pancreatic {beta}-cell apoptosis
Author(s): González-Pertusa JA, Dubé J, Valle SR, Rosa TC, Takane KK, Mellado-Gil JM, Perdomo G, Vasavada RC, García-Ocaña A
Year: 2010
Journal: Endocrinology
Volume: 151(4)
Page(s): 1487-98
Title: Moderate exercise attenuates the loss of skeletal muscle mass that occurs with intentional caloric restriction-induced weight loss in older, overweight to obese adults
Author(s): Chomentowski P, Dubé JJ, Amati F, Stefanovic-Racic M, Zhu S, Toledo FG, Goodpaster BH
Year: 2009
Journal: J Gerontol A Biol Sci Med Sci
Volume: 64(5)
Page(s): 575-80
Title: Improvements in insulin sensitivity are blunted by subclinical hypothyroidism
Author(s): Amati F, Dubé JJ, Stefanovic-Racic M, Toledo FG, Goodpaster BH
Year: 2009
Journal: Med Sci Sports Exerc
Volume: 41(2)
Page(s): 265-9
Title: Physical inactivity and obesity underlie the insulin resistance of aging
Author(s): Amati F, Dubé JJ, Coen PM, Stefanovic-Racic M, Toledo FG, Goodpaster BH
Year: 2009
Journal: Diabetes Care
Volume: 32(8)
Page(s): 1547-9
Title: Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity
Author(s): Liang H, Balas B, Tantiwong P, Dube J, Goodpaster BH, O'Doherty RM, DeFronzo RA, Richardson A, Musi N, Ward WF
Year: 2009
Journal: Am J Physiol Endocrinol Metab
Volume: 296(4)
Page(s): 945-54
Title: Separate and combined effects of exercise training and weight loss on exercise efficiency and substrate oxidation
Author(s): Amati F, Dubé JJ, Shay C, Goodpaster BH
Year: 2008
Journal: J Appl Physiol
Volume: 105(3)
Page(s): 825-31
Title: Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited
Author(s): Dubé JJ, Amati F, Stefanovic-Racic M, Toledo FG, Sauers SE, Goodpaster BH
Year: 2008
Journal: Am J Physiol Endocrinol Metab
Volume: 294(5)
Page(s): 882-8
Title: Leptin, skeletal muscle lipids, and lipid-induced insulin resistance
Author(s): Dube JJ, Bhatt BA, Dedousis N, Bonen A, O'Doherty RM
Year: 2007
Journal: Am J Physiol Regul Integr Comp Physiol
Volume: 293(2)
Page(s): 642-50
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