Department of Medicine

University of Pittsburgh

Division of Endocrinology and Metabolism
200 Lothrop Street
E1140 BST
Pittsburgh, PA 15213

Administrative/Research Office:
(412) 648-9770

Patient/Clinical Inquiries:
(412) 586-9700

John Dube, PhD

photo

Instructor of Medicine

Office: Montefiore University Hospital, N807
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-692-2257
Fax: 412-692-2165
E-mail: jjd8@pitt.edu

Education
BS, Shenandoah University, Winchester, VA, 1995
MS, James Madison University, Harrisonburg, VA, 1997
PhD, University of Pittsburgh, 2005

Training
Postdoctoral Fellowship, Endocrinology, University of Pittsburgh, 2009

Area of Specialization/Research Interest  
Human skeletal muscle lipid accumulation and its link to insulin resistance
 

Recent Peer-Reviewed Publications
Title: Effects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance`
Author(s): Dubé JJ, Coen PM, DiStefano G, Chacon AC, Helbling NL, Desimone ME, Stefanovic-Racic M, Hames KC, Despines AA, Toledo FG, Goodpaster BH
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Volume:
Page(s):
Title: Racial Differences in Peripheral Insulin Sensitivity And Mitochondrial Capacity In the Absence of Obesity
Author(s): DeLany JP, Dubé JJ, Standley RA, Distefano G, Goodpaster BH, Stefanovic-Racic M, Coen PM, Toledo FG
Year: 2014
Journal: J Clin Endocrinol Metab
Volume: 8
Page(s):
Title: Skeletal muscle as a regulator of the longevity protein, Klotho
Author(s): Avin KG, Coen PM, Huang W, Stolz DB, Sowa GA, Dubé JJ, Goodpaster BH, O'Doherty RM, Ambrosio F
Year: 2014
Journal: Front Physiol
Volume: 17
Page(s): 189
Title: Effect of a sustained reduction in plasma free fatty acid concentration on insulin signaling and inflammation in skeletal muscle from human subjects
Author(s): Liang H, Tantiwong P, Sriwijitkamol A, Shanmugasundaram K, Mohan S, Espinoza S, Dubé JJ, Defronzo RA, Musi N
Year: 2013
Journal: J Physiol
Volume: 591(pt11)
Page(s): 2897-909
Title: Reduced skeletal muscle oxidative capacity and elevated ceramide but not diacylglycerol content in severe obesity
Author(s): Coen PM, Hames KC, Leachman EM, Delany JP, Ritov VB, Menshikova EV, Dubé JJ, Toledo FG, Stefanovic-Racic M, Goodpaster BH
Year: 2013
Journal: Obesity (Silver Spring, Md)
Volume:
Page(s):
Title: Lower thigh subcutaneous and higher visceral abdominal adipose tissue content both contribute to insulin resistance
Author(s): Amati F, Pennant M, Azuma K, Dubé JJ, Toledo FG, Rossi AP, Kelley DE, Goodpaster BH
Year: 2012
Journal: Obesity (Silver Spring, Md)
Volume: 20 (5)
Page(s): 1115-7
Title: DHA reduces the atrophy-associated Fn14 protein in differentiated myotubes during coculture with macrophages
Author(s): Finlin BS, Varma V, Nolen GT, Dubé JJ, Starnes CP, Rasouli N, Kern PA, Peterson CA
Year: 2012
Journal: J Nutr Biochem
Volume: 23(8)
Page(s): 885-91
Title: Exercise dose and insulin sensitivity: relevance for diabetes prevention
Author(s): Dubé JJ, Allison KF, Rousson V, Goodpaster BH, Amati F
Year: 2012
Journal: Med Sci Sports Exerc
Volume: 44 (5)
Page(s): 793-9
Title: Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide
Author(s): Dubé JJ, Amati F, Toledo FG, Stefanovic-Racic M, Rossi A, Coen PM, Goodpaster BH
Year: 2011
Journal: Diabetologia
Volume: 54 (5)
Page(s): 1147-56
Title: Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?
Author(s): Amati F, Dubé JJ, Alvarez-Carnero E, Edreira MM, Chomentowski P, Coen PM, Switzer GE, Bickel PE, Stefanovic-Racic M, Toledo FG, Goodpaster BH
Year: 2011
Journal: Diabetes
Volume: 60 (10)
Page(s): 2588-97
For Pub Med search results, click here.