Department of Medicine

University of Pittsburgh

Division of Endocrinology and Metabolism
200 Lothrop Street
E1140 BST
Pittsburgh, PA 15213
Administrative/Research Office: (412) 648-9770
Patient/Clinical Inquiries: (412) 586-9700

Nathalie Fiaschi-Taesch, PhD

Assistant Professor of Medicine

Office: E1140 BST
200 Lothrop St.
Pittsburgh, PA 15261
Phone: 412-648-9661
Fax: 412-648-3290

BS, Biology, Universite Louis Pasteur, Strasbourg, France, 1994
MS, Physiology, Universite Louis Pasteur, Strasbourg, France, 1995
Degree in Advances Studies, Pharmacology, Universite Louis Pasteur, Strasbourg, France, 1996
PhD, Universite Louis Pasteur, Strasbourg, France, 2000

Postdoctoral Research Fellow, University of Pittsburgh, Endocrinology, 2002

Area of Specialization/Research Interest  
Vascular smooth muscle cell growth
Vascular actions of PTHrP
Therapy for arterial re-stenosis
Pancreatic islet transplantation

Dr. Fiaschi-Taesch is an Assistant Professor in the Div. of Endocrinology at Pitt. Her research focuses on vascular proliferative diseases, but also on islets transplantation. Her current research interests include: 1)PTHrP as a regulator of vascular smooth cell cycle and neointima formation; 2) Mutant forms of PTHrP as inhibitors of re-stenosis; 3)Hepatocyte Growth Factor as an agent to enhance engraftment and function of Non-Human Primate Islets and Human Primate islets; 4)Therapeutic angiogenesis for improving islet revascularization.

Recent Grants
Title: Relief of Cell Cycle Inhibition for Human Beta Cell Proliferation
Role: Co-PI
Funding Agency: JDRF
Start Year: 2008
End Year: 2011
Title: Activation of Human Beta Cell Replication
Role: Co-PI
Funding Agency: JDRF
Start Year: 2008
End Year: 2011

Recent Peer-Reviewed Publications
Title: Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6
Author(s): Fiaschi-Taesch NM, Salim F, Kleinberger J, Troxell R, Cozar-Castellano I, Selk K, Cherok E, Takane KK, Scott DK, Stewart AF
Year: 2010
Journal: Diabetes
Volume: 59(8)
Page(s): 1926-36
Title: Endogenous parathyroid hormone-related protein regulates the expression of PTH type 1 receptor and proliferation of vascular smooth muscle cells
Author(s): Song GJ, Fiaschi-Taesch N, Bisello A
Year: 2009
Journal: Mol Endocrinol
Volume: 23(10)
Page(s): 1681-90
Title: Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo
Author(s): Fiaschi-Taesch N, Bigatel TA, Sicari B, Takane KK, Salim F, Velazquez-Garcia S, Harb G, Selk K, Cozar-Castellano I, Stewart AF
Year: 2009
Journal: Diabetes
Volume: 58(4)
Page(s): 882-93
Title: Mutant parathyroid hormone-related protein, devoid of the nuclear localization signal, markedly inhibits arterial smooth muscle cell cycle and neointima formation by coordinate up-regulation of p15Ink4b and p27kip1
Author(s): Fiaschi-Taesch N, Sicari B, Ubriani K, Cozar-Castellano I, Takane KK, Stewart AF
Year: 2009
Journal: Endocrinology
Volume: 150(3)
Page(s): 1429-39
Title: Lessons from the first comprehensive molecular characterization of cell cycle control in rodent insulinoma cell lines
Author(s): Cozar-Castellano I, Harb G, Selk K, Takane K, Vasavada R, Sicari B, Law B, Zhang P, Scott DK, Fiaschi-Taesch N, Stewart AF
Year: 2008
Journal: Diabetes
Volume: 57(11)
Page(s): 3056-68
Title: Hepatocyte growth factor enhances engraftment and function of nonhuman primate islets
Author(s): Fiaschi-Taesch NM, Berman DM, Sicari B, Takane KK, Garcia-Ocana A, Ricordi C, Kenyon NS, Stewart AF
Year: 2008
Journal: Diabetes
Volume: 57(10)
Page(s): 2745-54