Department of Medicine

University of Pittsburgh

Division of Endocrinology and Metabolism
200 Lothrop Street
E1140 BST
Pittsburgh, PA 15213

Administrative/Research Office:
(412) 648-9770

Patient/Clinical Inquiries:
(412) 586-9700

James DeLany, PhD


Associate Professor of Medicine

Office: N810 Montefiore Hospital
3459 Fifth Avenue
Pittsburgh, PA 15213
Phone: 412-692-2848
Fax: 412-692-2165

BS, The Ohio State University, 1979
PhD, The Ohio State University, 1986

Laboratory Technician, The Ohio State University, 1987
Research Assoc -NIH Training Grant, The Ohio State University, 1989

Area of Specialization/Research Interest  
Energy expenditure and physical activity
Substrate metabolism
Insulin sensitivity
Skeletal muscle characteristics, including mitochondrial function in relation to peripheral insulin sensitivity
Application of stable isotope methodologies to study in vivo metabolism

Dr. DeLany received his Ph.D. in Human Nutrition from The Ohio State University in 1986. After completing a post-doctoral fellowship at the University of Chicago with a focus on stable isotope methodology, he was recruited to establish a stable isotope laboratory at the Pennington Biomedical Research Center, where he was engaged in the study of energy metabolism, obesity and obesity related diseases for the next 16 years.

While Dr. DeLany continues his research in energy metabolism, since joining the faculty of the Division of Endocrinology and Metabolism in 2005, a new focus is the study of substrate utilization, ectopic fat accumulation, insulin sensitivity, skeletal muscle characteristics and mitochondrial function as they relate to the increased risk of developement of diabetes in African-American women.

In addition, as the Director of the Mass Spectrometry Lab, Dr. DeLany provides the scientific leadership and technical expertise for the Lab to be able to function as a "core laboratory" for stable isotope methodologies and quantification of blood and tissue compounds for investigators within the University of Pittsburgh community as well as outside investigators who need these services.

Recent Grants
Title: Motor Proficiency, Physical Activity and Energy Expenditure in Adult Survivors of Childhood ALL
Role: Co-Investigator
Amount: $381,323
Funding Agency: NIH
Start Year: 2009
End Year: 2013

Recent Peer-Reviewed Publications
Title: Racial Differences in Peripheral Insulin Sensitivity And Mitochondrial Capacity in the Absence of Obesity
Author(s): DeLany JP, Dube JJ, Standley RA, Distefano G, Goodpaster BH, Stefanovic-Racic M, Coen PM, Toledo FG
Year: 2014
Journal: J Clin Endocrinol Metab
Title: African American women exhibit similar adherence to intervention but lose less weight due to lower energy requirements
Author(s): DeLany JP, Jakicic JM, Lowery JB, Hames KC, Kelley DE, Goodpaster BH
Year: 2013
Journal: Int J Obes (London)
Volume: 10.1038
Title: Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity.
Author(s): Mihalik SJ, Goodpaster BH, Kelley DE, Chace DH, Vockley J, Toledo FG, DeLany JP
Year: 2010
Journal: Obesity (Silver Spring)
Volume: 18(9)
Page(s): 1695-700
Title: Estimating the changes in energy flux that characterize the rise in obesity prevalence
Author(s): Swinburn BA, Sacks G, Lo SK, Westerterp KR, Rush EC, Rosenbaum M, Luke A, Schoeller DA, DeLany JP, Butte NF, Ravussin E
Year: 2009
Journal: Am J Clini Nutr
Volume: 89(6)
Page(s): 1723-8
Title: Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss
Author(s): Redman LM, Heilbronn LK, Martin CK, de Jonge L, Williamson DA, Delany JP, Ravussin E; Pennington CALERIE Team
Year: 2009
Journal: PLoS One
Volume: 4(2)
Page(s): 4377
Title: Low or moderate dietary energy restriction for long-term weight loss: what works best?
Author(s): Das SK, Saltzman E, Gilhooly CH, DeLany JP, Golden JK, Pittas AG, Dallal GE, Bhapkar MV, Fuss PJ, Dutta C, McCrory MA, Roberts SB
Year: 2009
Journal: Obesity (Silver Spring)
Volume: 17(11)
Page(s): 2019-24
Title: Physical activity in aging: comparison among young, aged, and nonagenarian individuals
Author(s): Johannsen DL, DeLany JP, Frisard MI, Welsch MA, Rowley CK, Fang X, Jazwinski SM, Ravussin E, Louisiana Healthy Aging Study
Year: 2008
Journal: J Appl Physiol
Volume: 105(2)
Page(s): 495-501
Title: New method for GC/FID and GC-C-IRMS analysis of plasma free fatty acid concentration and isotopic enrichment
Author(s): Kangani CO, Kelley DE, Delany JP
Year: 2008
Journal: J Chromatogr B Analyt Technol Biomed Life Sci
Volume: 873(1)
Page(s): 95-101
Title: Gene expression microarray analysis of the effects of grape anthocyanins in mice: a test of a hypothesis-generating paradigm
Author(s): Lefevre M, Wiles JE, Zhang X, Howard LR, Gupta S, Smith AA, Ju ZY, DeLany JP
Year: 2008
Journal: Metabolism
Volume: 57(7 Suppl 1)
Page(s): 52-57
Title: Determination of food portion size by image processing
Author(s): Sun M, Liu Q, Schmidt K, Yang J, Yao N, Fernstrom JD, Fernstrom MH, DeLany JP, Sclabassi RJ
Year: 2008
Journal: Conf Proc IEEE Eng Med Biol Soc
Volume: 2008
Page(s): 871-4
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