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Department of Medicine

Department of Medicine

  Division of Endocrinology and Metabolism

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photo Robert M. O'Doherty, PhD

Professor of Medicine

Professor of Biochemistry and Molecular Genetics

Director, T32 Diabetes and Endocrinology Training Program

Co-Director, Center for Metabolic and Mitochondrial Medicine (C3M)

Email: rmo1@pitt.edu

Phone: 412-648-3320

Contact
Office: E1140 Biomedical Science Tower
200 Lothrop Street
Pittsburgh, PA 15213
 
Phone: 412-648-3320
Fax: 412-648-3290
E-mail: rmo1@pitt.edu
Education and Training
Education
B.A., University of Dublin, 1986
PhD, Vanderbilt University, 1995
Training
Postdoctoral Fellow, Diabetes/Obesity, University of Texas, Southwestern Medical Center, 1998
Research Interest
Dr. O'Doherty's overarching research interests are in questions related to the association between states of over nutrition and resulting metabolic disturbances, most notably obesity, NAFLD, and Type 2 Diabetes. Dr. O'Doherty has accumulated nearly twenty five years experience in this arena, utilizing a range of metabolic, physiological, biochemical, molecular and immunological approaches in a range of models, notably the mouse and rat, primary tissue culture, and immortal cell lines. The major foci of his current research efforts are in the area of immunometabolism, that is the role of immune system in the regulation of metabolism.
Publications
For my complete bibliography, Click Here.
Selected Publications:
He, J., Gao, J., Xu, M., Ren, S., Stefanovic-Racic, M., O'Doherty, R.M., Xie, W. PXR ablation alleviates diet-induced and genetic obesity and insulin resistance in mice. Diabetes. 2013; 62(6): 1876-87.
Shi, X., Cheng, Q., Xu, L., Yan, J., Jiang, M., He, J., Xu, M., Stefanovic-Racic, M., Sipula, I.J., O'Doherty, R.M., Ren, S., Xie, W. Cholesterol sulfate and cholesterol sulfotransferase inhibit gluconeogenesis by targeting hepatocyte nuclear factor 4a. Molecular and Cellular Biology. 2014; 34(3): 485-97.
Jiang, M., He, J., Kucera, H., Gaikwad, N.W., Zhang, B., Xu, M., O'Doherty, R.M., Selcer, K.W., Xie, W. Hepatic overexpression of steroid sulfatase ameliorates mouse models of obesity and type 2 diabetes through sex-specific mechanisms. The Journal of Biological Chemistry. 2014; 289(12): 8086-97.
Avin, K.G., Coen, P.M., Huang, W., Stolz, D.B., Sowa, G.A., Dubé, J.J., Goodpaster, B.H., O'Doherty, R.M., Ambrosio, F. Skeletal muscle as a regulator of the longevity protein, Klotho. Frontiers in Physiology. 2014; 5: 189.
Chartoumpekis, D.V., Palliyaguru, D.L., Wakabayashi, N., Khoo, N.K., Schoiswohl, G., O'Doherty, R.M., Kensler, T.W. Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice. Molecular Metabolism. 2015; 4(7): 543-50.
Edmunds, L.R., Otero, P.A., Sharma, L., D'Souza, S., Dolezal J.M., David, S., Lu, J., Lamm, L., Basantani, M., Zhang, P., Sipula, I.J., Li, L., Zeng, X., Ding, Y., Ding, F., Beck, M.E., Vockley, J., Monga, S.P., Kershaw, E.E., O'Doherty, R.M., Kratz L.E., Yates N.A., Goetzman E.P., Scott, D., Duncan A.W., Prochownik, E.V. Abnormal lipid processing but normal long-term repopulation potential of myc-/- hepatocytes. Oncotarget. 2016.
Schoiswohl, G., Stefanovic-Racic, M., Menke, M.N., Wills, R.C., Surlow, B.A., Basantani, M.K., Sitnick, M.T., Cai, L., Yazbeck, C.F., Stolz, D.B., Pulinilkunnil, T., O'Doherty, R.M., Kershaw, E.E. Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice. Endocrinology. 2015; 156(10): 3610-24.
Martins, F.O., Delgado, T.C., Viegas, J., Gaspar, J.M., Scott, D.K., O'Doherty, R.M., Macedo, M.P., Jones, J.G. Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia. British Journal of Pharmacology. 2016; 173(2): 267-78.
Costa, D.K., Huckestein, B.R., Edmunds, L.R., Petersen, M.C., Nasiri, A., Butrico, GM, Abulizi, A., Harmon, D.B., Lu, C., Mantell, B.S., Hartman, D.J., Camporez, J.P., O'Doherty, R.M., Cline, G.W., Shulman, G.I., Jurczak, M.J. Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice. The American Journal of Physiology- Endocrinology & Metabolism. 2016; 311(1): E105-16.
Krishna, K.B., Stefanovic-Racic, M., Dedousis, N., Sipula, I.J., O'Doherty, R.M. Similar degrees of obesity induced by diet or aging cause strikingly different immunologic and metabolic outcomes. Physiological Reports. 2016; 4(6).
Sponsored Research/Activities
Title: Dendritic Cells and Obesity
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK102839
Start Year: 2015
End Year: 2019
Title: Cellular and Molecular Mechanisms of HSC Dysfunction in Chronic Inflammation
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R56 AI079047
Start Year: 2015
End Year: 2016
Title: Nitrite and Hypoxia Increases Biogenesis and Insulin Sensitivity
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL111706
Start Year: 2013
End Year: 2017
Title: The Role of Myc in ChREBP-Dependent, Glucose-Stimulated Gene Expression
Role: Co-Investigator
Funding Agency: Mt. Sinai Medical Center/National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK065149
Start Year: 2012
End Year: 2016
Title: Islet Growth Factors: Transgenic and Viral Modeling
Role: Co-Investigator
Funding Agency: Mt. Sinai Medical Center/National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK055023
Start Year: 2012
End Year: 2013
Title: Multi-disciplinary Approaches to Driving Therapeutic Human Beta Cell Replication
Role: Co-Investigator
Funding Agency: Mt. Sinai Medical Center/National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: U01 DK089538
Start Year: 2012
End Year: 2013
Title: The Role of Myc in ChREBP-Dependent, Glucose-Stimulated Gene Expression
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK065149
Start Year: 2012
End Year: 2012
Title: Leptin Action and Macrophages
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK072162
Start Year: 2011
End Year: 2016
Title: Epigenomic Regulation of Gene Expression in Diet Induced Obesity
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R21 DK091673
Start Year: 2011
End Year: 2014
Title: Research Training in Diabetes and Endocrinology
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: T32 DK007052
Start Year: 2010
End Year: 2016
Notable Achievements
Editorial Board, American Journal of Physiology (Endo/Metabol), 2010-present