Department of Medicine

Department of Medicine

  Division of Endocrinology and Metabolism

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photo John J Dube, PhD

Assistant Professor of Biology, Chatham University

Adjunct Assistant Professor of Medicine, University of Pittsburgh


Phone: 412-780-0156

Office: 200 Lothrop Street
E1140 BST
Pittsburgh, PA 15213
Phone: 412-780-0156
Fax: 412-648-3290
Administrative Assistant:
Melissa Menifield
Address: Chatham University, Buhl Hall 231
Pittsburgh, PA
Phone: 412-365-1447
Education and Training
BS, Shenandoah University, 1995
MS, James Madison University, 1997
PhD, University of Pittsburgh, 2005
Postdoctoral Fellowship, Endocrinology, University of Pittsburgh, 2009
Research Interest
Dr. Dubé's current research interests include 1) the role of lipolysis in skeletal muscle biology, 2) substrate energetics in human health and disease with a special interest in sickle cell disease, and 3) the mechanisms associated with lifestyle interventions (diet and exercise) on tissue metabolism. His research involves cell culture, rodents models, and human clinical studies to address these important topics.
For my complete bibliography, Click Here.
Selected Publications:
Avin KG, Coen PM, Huang W, Stolz DB, Sowa GA, Dubé JJ, Goodpaster BH, O'Doherty RM, Ambrosio F. Skeletal muscle as a regulator of the longevity protein, Klotho. Front Physiol. 2014; 17: 189.
DeLany JP, Dubé JJ, Standley RA, Distefano G, Goodpaster BH, Stefanovic-Racic M, Coen PM, Toledo FG. Racial Differences in Peripheral Insulin Sensitivity And Mitochondrial Capacity In the Absence of Obesity. J Clin Endocrinol Metab. 2014; 8.
Dubé JJ, Coen PM, DiStefano G, Chacon AC, Helbling NL, Desimone ME, Stefanovic-Racic M, Hames KC, Despines AA, Toledo FG, Goodpaster BH. Effects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance`. Am J Physiol Endocrinol Metab. 2014.
Coen PM, Hames KC, Leachman EM, Delany JP, Ritov VB, Menshikova EV, Dubé JJ, Toledo FG, Stefanovic-Racic M, Goodpaster BH. Reduced skeletal muscle oxidative capacity and elevated ceramide but not diacylglycerol content in severe obesity. Obesity (Silver Spring, Md). 2013.
Liang H, Tantiwong P, Sriwijitkamol A, Shanmugasundaram K, Mohan S, Espinoza S, Dubé JJ, Defronzo RA, Musi N. Effect of a sustained reduction in plasma free fatty acid concentration on insulin signaling and inflammation in skeletal muscle from human subjects. J Physiol. 2013; 591(pt11): 2897-909.
Amati F, Pennant M, Azuma K, Dubé JJ, Toledo FG, Rossi AP, Kelley DE, Goodpaster BH. Lower thigh subcutaneous and higher visceral abdominal adipose tissue content both contribute to insulin resistance. Obesity (Silver Spring, Md). 2012; 20 (5): 1115-7.
Dubé JJ, Allison KF, Rousson V, Goodpaster BH, Amati F. Exercise dose and insulin sensitivity: relevance for diabetes prevention. Med Sci Sports Exerc. 2012; 44 (5): 793-9.
Finlin BS, Varma V, Nolen GT, Dubé JJ, Starnes CP, Rasouli N, Kern PA, Peterson CA. DHA reduces the atrophy-associated Fn14 protein in differentiated myotubes during coculture with macrophages. J Nutr Biochem. 2012; 23(8): 885-91.
Amati F, Dubé JJ, Alvarez-Carnero E, Edreira MM, Chomentowski P, Coen PM, Switzer GE, Bickel PE, Stefanovic-Racic M, Toledo FG, Goodpaster BH. Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?. Diabetes. 2011; 60 (10): 2588-97.
Dubé JJ, Amati F, Toledo FG, Stefanovic-Racic M, Rossi A, Coen PM, Goodpaster BH. Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide. Diabetologia. 2011; 54 (5): 1147-56.