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Department of Medicine

Department of Medicine

  Division of Endocrinology and Metabolism

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photo James P DeLany, PhD

Research Associate Professor of Medicine

Email: jpd21@pitt.edu

Phone: 412-692-2848

Contact
Office: N815.1 Montefiore Hospital
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-692-2848
Fax: 412-692-2165
E-mail: jpd21@pitt.edu
Administrative Assistant:
Kelli Lange
Address: 200 Lothrop Street
E1140 BST
Pittsburgh, PA 15213
Email: kal134@pitt.edu
Phone: 412-648-8630
Fax: 412-648-3290
Education and Training
Education
BS, The Ohio State University, 1979
PhD, The Ohio State University, 1986
Training
Laboratory Technician, The Ohio State University, 1987
Research Assoc -NIH Training Grant, The Ohio State University, 1989
Post Doctoral Trainee, The University of Chicago, 1989
Research Interest
Dr. DeLany’s research interests include: (1) the role of energy expenditure, physical activity and energy intake in the development of obesity and in effective weight loss, and changes during and after weight loss through bariatric surgery and behavioral intervention; 2) understanding the relation between skeletal muscle characteristics, mitochondrial function, substrate utilization, body composition and insulin sensitivity; and (3) examining metabolic factors related to the increased risk of development of obesity and diabetes in African-American women. In studies of energy metabolism and physical activity, state of the art methodology is applied, including longitudinal measures of body composition by dual energy x-ray absorptiometry, and total energy expenditure by doubly labeled water, assessment of resting metabolic rate and substrate utilization by indirect calorimetry, and the use of multisensor physical activity monitors. For examination of insulin sensitivity, state of the art methodology, including hyperinsulinemic, euglycemic clamps with stable isotope glucose tracer to differentiate between liver and peripheral insulin sensitivity, skeletal muscle biopsies, high resolution respirometry, histology and electron microscopy are utilized. Ongoing and planned studies will include examination of the role mitochondrial genetics in insulin sensitivity and positron emission tomography studies of skeletal muscle and adipose tissue glucose metabolism. In addition, Dr. DeLany provides scientific leadership and technical expertise for the Mass Spectrometry Lab to be able to function as a “core laboratory” for stable isotope methodologies and quantification of blood and tissue compounds for investigators within the University of Pittsburgh community as well as outside investigators who need these services.
Publications
For my complete bibliography, Click Here.
Selected Publications:
DeLany JP, Dube JJ, Standley RA, Distefano G, Goodpaster BH, Stefanovic-Racic M, Coen PM, Toledo FG. Racial Differences in Peripheral Insulin Sensitivity And Mitochondrial Capacity in the Absence of Obesity. J Clin Endocrinol Metab. 2014.
DeLany JP, Jakicic JM, Lowery JB, Hames KC, Kelley DE, Goodpaster BH. African American women exhibit similar adherence to intervention but lose less weight due to lower energy requirements. Int J Obes (London). 2013; 10.1038.
Mihalik SJ, Goodpaster BH, Kelley DE, Chace DH, Vockley J, Toledo FG, DeLany JP. Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity. Obesity (Silver Spring). 2010; 18(9): 1695-700.
Das SK, Saltzman E, Gilhooly CH, DeLany JP, Golden JK, Pittas AG, Dallal GE, Bhapkar MV, Fuss PJ, Dutta C, McCrory MA, Roberts SB. Low or moderate dietary energy restriction for long-term weight loss: what works best?. Obesity (Silver Spring). 2009; 17(11): 2019-24.
Swinburn BA, Sacks G, Lo SK, Westerterp KR, Rush EC, Rosenbaum M, Luke A, Schoeller DA, DeLany JP, Butte NF, Ravussin E. Estimating the changes in energy flux that characterize the rise in obesity prevalence. Am J Clini Nutr. 2009; 89(6): 1723-8.
Redman LM, Heilbronn LK, Martin CK, de Jonge L, Williamson DA, Delany JP, Ravussin E; Pennington CALERIE Team. Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss. PLoS One. 2009; 4(2): 4377.
Gilhooly CH, Das SK, Golden JK, McCrory MA, Rochon J, DeLany JP, Freed AM, Fuss PJ, Dallal GE, Saltzman E, Roberts SB. Use of cereal fiber to facilitate adherence to a human caloric restriction program. Aging Clin Exp Res. 2008; 20(6): 513-20.
Sun M, Liu Q, Schmidt K, Yang J, Yao N, Fernstrom JD, Fernstrom MH, DeLany JP, Sclabassi RJ. Determination of food portion size by image processing. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008: 871-4.
Bray GA, Flatt JP, Volaufova J, Delany JP, Champagne CM. Corrective responses in human food intake identified from an analysis of 7-d food-intake records. Am J Clin Nutr. 2008; 88(6): 1504-10.
Kangani CO, Kelley DE, Delany JP. New method for GC/FID and GC-C-IRMS analysis of plasma free fatty acid concentration and isotopic enrichment. J Chromatogr B Analyt Technol Biomed Life Sci. 2008; 873(1): 95-101.
Sponsored Research/Activities
Title: Alliance of Randomized Trials of Medicine vs. Metabolic Surgery in Type 2 Diabetes: ARMMS-T2D
Role: Co-Investigator
Funding Agency: Cleveland Clinic
Start Year: 2015
End Year: 2017
Title: Decreased Fat Oxidation - Metabolic Inflexibility in African American Women
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R56 DK091462
Start Year: 2015
End Year: 2017
Title: Body Composition & REE Responses to Bariatric Surgeries
Role: Co-Investigator
Funding Agency: Columbia University/National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK072507
Start Year: 2015
End Year: 2016
Title: Noninvasive Fat Quantification of Liver Using Ultrasound Thermal Strain Imaging
Role: Co-Investigator
Funding Agency: National Institute of Biomedical Imaging and Bioengineering
Grant Number: R21 EB016907
Start Year: 2014
End Year: 2016
Title: AFSOC Injury Prevention and Human Performance Research Initiative
Role: Co-Investigator
Funding Agency: Air Force
Start Year: 2014
End Year: 2014
Title: Rediscovering Hydroxychloroquine as a Novel Insulin Sensitizer in Humans
Role: Co-Investigator
Funding Agency: American Diabetes Association
Start Year: 2013
End Year: 2016
Title: Skeletal Muscle Lipid and Insulin Resistance in Aging
Role: Co-Investigator
Funding Agency: Florida Hospital/National Institute of Aging
Grant Number: R01 AG021961
Start Year: 2013
End Year: 2016
Title: Ph 2 Study of Triheptanoin for Tx of Long-Chain Fatty Acid Oxidation Disorder
Role: Principal Investigator
Funding Agency: Oregon Health Sciences/Food and Drug Administration
Grant Number: R01 FD003895
Start Year: 2013
End Year: 2015
Title: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK095128
Start Year: 2013
End Year: 2015
Title: Body Composition & REE Responses to Bariatric Surgeries
Role: Co-Investigator
Funding Agency: St. Luke's Roosevelt Institute for Health Sci/National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK072507
Start Year: 2012
End Year: 2014
Title: Isotope Analysis and Data Modeling for the University of Utah Center for Clinical and Translational Science
Role: Principal Investigator
Funding Agency: University of Utah/National Institute of Health
Grant Number: KL2 TR000104
Start Year: 2012
End Year: 2013
Title: Decreased Fat Oxidation - Metabolic Inflexibility in African American Women
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK091462
Start Year: 2011
End Year: 2015
Title: Motor Proficiency and Physical Activity in Adult Survivors of Childhood ALL
Role: Co-Principal Investigator
Funding Agency: St. Jude Medical Center/National Cancer Institute
Grant Number: R01 CA132901
Start Year: 2009
End Year: 2013
Title: Improving Dietary Assessment Methods Using the Cell Phone and Digital Imaging
Role: Co-Investigator
Funding Agency: Univeristy of Hawaii/National Cancer Institute
Grant Number: U01 CA130784
Start Year: 2007
End Year: 2013
Notable Achievements
Ad Hoc Reviewer, NIH Review Panel- Population Sciences and Epidemiology, 2016
Ad Hoc Reviewer, Diet and Physical Activity Assessment Grants, 2016
Ad Hoc Reviewer, The National Institute of Diabetes and Digestive and Kidney Diseases, 2016