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Department of Medicine

Department of Medicine

  Division of Cardiology

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Jianhui Zhu, MD,PhD

Research Assistant Professor of Medicine

Email: zhuj@upmc.edu

Phone: 412-648-9721

Contact
Office: Scaife Hall S950.1
200 Lothrop Street
Pittsburgh, 15213
 
Phone: 412-648-9721
Fax:
E-mail: zhuj@upmc.edu
Education and Training
Education
MD, Nantong University School of Medicine, 1984
M.Med, Fudan University Shanghai Medical College, 1990
PhD, The Chinese University of Hong Kong, 2000
Training
Postdoc, University of Pittsburgh, 2003
Research Interest
1. Ultrasound mediated gene/drug delivery in treatment of tumors and cardiovascular diseases.
2. The role of intracellular signaling pathways in mediating mitochondrial biogenesis and dynamics.
3. Implication of autophagy-lysosome dysfunction in mitochondrial homeostasis and cell survival
Publications
For my complete bibliography, Click Here.
Selected Publications:
Dagda RK, Pien I, Wang R, Zhu J, Wang KZ, Callio J, Banerjee TD, Dagda RY, Chu CT. Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through protein kinase A. Journal of neurochemistry. 2014; 128(6): 864-77.
Zhu J, Wang KZ, Chu CT. After the banquet: mitochondrial biogenesis, mitophagy, and cell survival. Autophagy. 2013; 9(11): 1663-76.
Chu CT, Ji J, Dagda RK, Jiang JF, Tyurina YY, Kapralov AA, Tyurin VA, Yanamala N, Shrivastava IH, Mohammadyani D, Qiang Wang KZ, Zhu J, Klein-Seetharaman J, Balasubramanian K, Amoscato AA, Borisenko G, Huang Z, Gusdon AM, Cheikhi A, Steer EK, Wang R, Baty C, Watkins S, Bahar I, Bayir H, Kagan VE. Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. Nature cell biology. 2013; 15(10): 1197-205.
Zhu J, Gusdon AM, Cimen H, Van Houten B, Koc E, Chu CT. Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity: dual roles for ERK1/2. Cell death & disease. 2012; 3: e312.
Gusdon AM, Zhu J, Van Houten B, Chu CT. ATP13A2 regulates mitochondrial bioenergetics through macroautophagy. Neurobiology of disease. 2012; 45(3): 962-72.
Zhu J, Dagda RK, Chu CT. Monitoring mitophagy in neuronal cell cultures. Methods in molecular biology (Clifton NJ). 2011; 793: 325-39.
Hu X, Weng Z, Chu CT, Zhang L, Cao G, Gao Y, Signore A, Zhu J, Hastings T, Greenamyre JT, Chen J. Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011; 31(1): 247-61.